DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10051 and Ermp1

DIOPT Version :9

Sequence 1:	NP_611414.1	Gene:	CG10051 / 37222	FlyBaseID:	FBgn0034437	Length:	866	Species:	Drosophila melanogaster
Sequence 2:	NP_001349060.1	Gene:	Ermp1 / 226090	MGIID:	106250	Length:	899	Species:	Mus musculus

Alignment Length:	900	Identity:	261/900 - (28%)
Similarity:	438/900 - (48%)	Gaps:	97/900 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 KDGGKSRDKKWPWFGAPIYAAAAFALFYAAVLPSF-YSYPKMLYQSEEALHPDKFIGERAMRQLA 75
            ::||.||..|.....|  ..|.|.||:..|:.... .|..:::......|.     ||...||..
Mouse    50 ENGGGSRVAKTALSEA--RTALALALYLLALRALVQLSLQRLVLSRTSGLQ-----GEFDARQAR 107

  Fly    76 EY----SAIGNKMSGSINNEVHTINFLLREIQKIKDEARLDLYDIEVDTQYSSGAF---HLWGMT 133
            :|    :|||.:.:||..||:.|:.:||.:|:.|:.::. .|:.|.||.|..:|:|   .|.|.|
Mouse   108 DYLEHITAIGPRTTGSTENEILTVQYLLEQIKLIEAQSN-SLHSISVDIQRPTGSFSIDFLGGFT 171

  Fly   134 ISYTNLSNVVVKISQKSSDNENYLLVNSHYDSEVQTPAAGDDGVMVVVMLETLRVISRSERTLTH 198
            ..|.|::|||||:..:.. .|:.:|.|.|:||...:|.|.||.|...||||.|||:|.|...:.|
Mouse   172 SYYDNITNVVVKLEPRDG-AESAILANCHFDSVANSPGASDDAVSCAVMLEVLRVMSASPEPMQH 235

  Fly   199 PVVFLFNGAEEACMLGSHGFITQHKWSKNCKALVNLDSTGAGGREVLFQTGPNHPWLAKYYQASV 263
            .||||||||||..:..||||||||.|:...:|.:||::.|.||:|::|||||.:|||.:.|.::.
Mouse   236 AVVFLFNGAEENVLQASHGFITQHPWASLIRAFINLEAAGVGGKELVFQTGPENPWLVQAYVSAA 300

  Fly   264 PHPYAQTLAEELFQHNFIPSDTDFRIFRDYGGVPGLDMASVMNGYVYHTEFDNFKNVEYGTYQST 328
            .||:|..:|:|:||...|||||||||:||:|.:||:|:|.:.|||:|||::|....:...:.|..
Mouse   301 KHPFASVVAQEVFQSGIIPSDTDFRIYRDFGNIPGIDLAFIENGYIYHTKYDTADRILIDSIQRA 365

  Fly   329 GENVLPLIWALANAPELDNTTAYEKGHTVYYDFLGWFMMTYTESVSIAINVVVSVAAFICIGTSV 393
            |:|:|.::..||.:..|.:::.|..|..|::|.||..::.|...|...||.:|.:|..:.:|..:
Mouse   366 GDNILAVLKHLATSDTLASSSEYRHGSMVFFDVLGLLVIAYPSRVGSIINYMVVMAVVLYLGKKL 430

  Fly   394 YIMTLDNGADAPKAVVLRFAIIFLVQAGTLFV----ACGLTLLVAVFMQGVGLAESWYYGKWMAF 454
            .         .||.....:...||...|..|:    :....|::|||:..:|.:.|||...::|.
Mouse   431 L---------RPKHRNANYMRDFLCGLGITFISWFTSLVTVLIIAVFISLIGQSLSWYNYFYIAV 486

  Fly   455 GLY----------FCTLFFAFGILPAT--YIGFTKRKTNMKLDQTIACFMHAQCILLALLCIIMT 507
            .||          ..||...|..:.|:  |:|      .:..|.::  |:|  |..|    :.:|
Mouse   487 CLYGTATVAKIIFIHTLAKRFYYMNASDLYLG------ELFFDTSL--FVH--CAFL----VALT 537

  Fly   508 IMGIRSSYFPMVGIFFYAISVLVQIVLKLTLKKSY--------FVTVHLLFQVLPFFFYTYICYA 564
            ..|..|:       |..|:.|:..::.||.:.|.:        ||.::||...:|:.:..|:.:|
Mouse   538 YQGFCSA-------FMSAVWVVFPLLTKLCVYKDFKKHGAQGRFVALYLLGMFIPYLYGLYLIWA 595

  Fly   565 TLVTFVPMEGRDGPESSPDIMISVFIIATAINYAGFVIPIMHKFRKPKIIFSSFGVITIIFIILA 629
            ....|.|:.||.|.|..||::::..:....:..:.:.|..::.....|....:..::..:..:|.
Mouse   596 VFEMFTPILGRSGSEIPPDVVLASILAVCVMILSSYFITFIYLVNSTKKTILTLILVCAVTFLLV 660

  Fly   630 CTSAGFPF---VKQLAPQRYYVLHTQRTFHNLDGT-SKQDSGYYIQPVD--------TRLHELDD 682
            |:.|.||:   .:...|:|.::.|..||||||:|: .|:|||.:|...|        ..:.|::|
Mouse   661 CSGAFFPYSSNPESPKPKRVFLQHVSRTFHNLEGSVVKRDSGIWINGFDYTGMSHVTPHIPEIND 725

  Fly   683 TTFKNAEPESWTAATCAAEPYCGLPLYSGRWIEWKDSARWIYSSPPVIPMN-INLTQLSKQSLDG 746
            |...:.|.::         |.||.|.|..  :.:.....|...:|.|.|.| .:...:||:.:..
Mouse   726 TIRAHCEEDA---------PLCGFPWYLP--VHFLIRKNWYLPAPEVSPRNPAHFRLVSKEKMPW 779

  Fly   747 NKVRYEYNLRASDRVMMYIDPLDNVKVTDWSFDHTPLVEKHTPPYLIYAIYSQTEEPLNFWVELE 811
            :.::..:.......:..|:.......::.||..:...|......|.::..:........||:|::
Mouse   780 DSIKLTFEATGPSHMSFYVRTHKGSTLSQWSLGNGIPVTSRGGDYFVFYSHGLQASAWRFWIEVQ 844

  Fly   812 H-EEGNTDGPYMKLVVSEHFQYHPEYYTEEYKEFLATFPDWTYTTDWFSALESWI 865
            . .|...:| .:.:.::.|:.......:.:.......||||::.:.|.|....::
Mouse   845 QVSEEQAEG-MVTVAIAAHYLSGENKRSSQLDALKKKFPDWSFPSAWVSTYSLFV 898

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10051	NP_611414.1	M28_Fxna_like	62..369	CDD:193497	133/313 (42%)
CG10051	NP_611414.1	MATE_like	361..>604	CDD:298879	62/266 (23%)
Ermp1	NP_001349060.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..55		2/4 (50%)
Ermp1	NP_001349060.1	M28_Fxna_like	99..406	CDD:193497	133/308 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167835893
Domainoid	1	1.000	247	1.000	Domainoid score	I2148
eggNOG	1	0.900	-	-		E1_COG2234
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H121891
Inparanoid	1	1.050	426	1.000	Inparanoid score	I1734
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG59376
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000591
OrthoInspector	1	1.000	-	-		otm42620
orthoMCL	1	0.900	-	-		OOG6_101747
Panther	1	1.100	-	-	O	PTHR12147
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X435
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.760