DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10051 and gcp-2.2

DIOPT Version :9

Sequence 1:	NP_611414.1	Gene:	CG10051 / 37222	FlyBaseID:	FBgn0034437	Length:	866	Species:	Drosophila melanogaster
Sequence 2:	NP_509928.3	Gene:	gcp-2.2 / 183230	WormBaseID:	WBGene00007954	Length:	779	Species:	Caenorhabditis elegans

Alignment Length:	391	Identity:	78/391 - (19%)
Similarity:	133/391 - (34%)	Gaps:	157/391 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 VLPSFYSYPKMLYQS--EEALHPDKFIGERAMRQLAEYSAIGNKMSGSINNE-----VHTINFLL 99
            :||..|:..::|:::  .:|::.| |.|:  :.....|.      .|.|||:     ||..| ..
Worm   316 MLPITYATAQILFENMKGDAVNAD-FQGK--LNVTYRYG------PGLINNQKLRVTVHAEN-EE 370

  Fly   100 REIQKIKDEARLDLYDIEVDTQYSSGAFHLWGMTISYTNLSNVVVKISQKSSDNENYLLVNSHYD 164
            |:||.|..              |..|                        |.:.:.::||::|||
Worm   371 RKIQNIMG--------------YIKG------------------------SQEPDKFVLVSNHYD 397

  Fly   165 SEVQTPAAGDDGVMVVVMLETLRVISRSERTL----THPVVFLFNGAEEACMLGSHGFITQHKWS 225
            :  .|..|.|.......:||..|.:.:.:...    ...::|....|||..::||..|..:::..
Worm   398 A--WTYGAVDPNSGTSTLLEVSRALKQYQNQTGWIPARSILFAHWDAEEYGLIGSTEFAEEYRLQ 460

  Fly   226 --KNCKALVNLDSTGAG--------------------------------GREVLFQTGPNHPWLA 256
              :...|::|:|..|..                                ||:.|:.:     |
Worm   461 LMRRAVAVINMDLIGGNQTLLGLSNPTVANVLRSAAANVEQPNPTEMEQGRKTLYDS-----W-- 518

  Fly   257 KYYQAS----VPHPYAQTLAEELFQHNFIPS-DTDFRIFRDYGGVP-------GLDMASVMNGYV 309
            |||..|    ..|||.:           ||: .:|...|.||.|:|       .||......  :
Worm   519 KYYAPSKNNRSTHPYQR-----------IPAGGSDHLPFFDYLGIPIVFFITSSLDAPPTYP--L 570

  Fly   310 YHTEFDNFKNVEYGTYQSTGENVLPLIWALANAPELDNTTAYEKGHTVYYDFLGWF---MMTYTE 371
            |||.::....:         ||::                  :.|:.|:....|.|   ::.:||
Worm   571 YHTIYETPYLI---------ENIM------------------DPGYKVHKAIAGMFIECILKFTE 608

  Fly   372 S 372
            |
Worm   609 S 609

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10051	NP_611414.1	M28_Fxna_like	62..369	CDD:193497	70/364 (19%)
CG10051	NP_611414.1	MATE_like	361..>604	CDD:298879	5/15 (33%)
gcp-2.2	NP_509928.3	Zinc_peptidase_like	75..>133	CDD:301362
		PA_GCPII_like	137..364	CDD:239036	13/56 (23%)
		M28_PSMA_like	372..614	CDD:193568	61/325 (19%)
		TFR_dimer	652..773	CDD:282153
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2234
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900