DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10051 and CPQ

DIOPT Version :9

Sequence 1:	NP_611414.1	Gene:	CG10051 / 37222	FlyBaseID:	FBgn0034437	Length:	866	Species:	Drosophila melanogaster
Sequence 2:	NP_057218.1	Gene:	CPQ / 10404	HGNCID:	16910	Length:	472	Species:	Homo sapiens

Alignment Length:	307	Identity:	72/307 - (23%)
Similarity:	123/307 - (40%)	Gaps:	35/307 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 FYSYPKML-YQSEEALHPDKFIGERA--MRQLAEYSAIGNKMSG--SINNEVHTINFLLREIQKI 105
            :.:|.:.: |:::.|:...| :|..|  :|.:|.:| |.:..:|  ...:.|..|......::..
Human   177 YINYSRTVQYRTQGAVEAAK-VGALASLIRSVASFS-IYSPHTGIQEYQDGVPKIPTACITVEDA 239

  Fly   106 KDEARLDLYDIEVDTQYSSGAFHLWGMTISYTNLSNVVVKISQKSSDNENYLLVNSHYDSEVQTP 170
            :..:|:..:.|::..|...||     .|...|:..|.|.:|: .|...|..:||:.|.||.....
Human   240 EMMSRMASHGIKIVIQLKMGA-----KTYPDTDSFNTVAEIT-GSKYPEQVVLVSGHLDSWDVGQ 298

  Fly   171 AAGDDGVMVVVMLETLRVIS----RSERTLTHPVVFLFNGAEEACMLGSHGFITQHKWSKNCKAL 231
            .|.|||....:..|.|.:|.    |.:|||.   :.|:. |||...:|:..:...||.:.:..:|
Human   299 GAMDDGGGAFISWEALSLIKDLGLRPKRTLR---LVLWT-AEEQGGVGAFQYYQLHKVNISNYSL 359

  Fly   232 VNLDSTGAGGREVLFQTGPNHPWLAKYYQASVPHPYAQTLAEELFQHNFIPSDTDFRIFRDYGGV 296
            |.....|......|..||............|:..|...|   ::..|.   ..||.. |....||
Human   360 VMESDAGTFLPTGLQFTGSEKARAIMEEVMSLLQPLNIT---QVLSHG---EGTDIN-FWIQAGV 417

  Fly   297 PGLDMASVMNGYVY--HTEFDNFKNVEYGTYQSTGENVLPLIWALAN 341
            ||..:...:..|.:  |:..|....::     ....||...:||:.:
Human   418 PGASLLDDLYKYFFFHHSHGDTMTVMD-----PKQMNVAAAVWAVVS 459

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10051	NP_611414.1	M28_Fxna_like	62..369	CDD:193497	69/290 (24%)
CG10051	NP_611414.1	MATE_like	361..>604	CDD:298879
CPQ	NP_057218.1	M28_Pgcp_like	47..449	CDD:193504	68/295 (23%)
CPQ	NP_057218.1	PA_M28_2	130..256	CDD:240119	15/80 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2234
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900