DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10051 and ermp1

DIOPT Version :9

Sequence 1:	NP_611414.1	Gene:	CG10051 / 37222	FlyBaseID:	FBgn0034437	Length:	866	Species:	Drosophila melanogaster
Sequence 2:	XP_004910853.1	Gene:	ermp1 / 100145630	XenbaseID:	XB-GENE-984733	Length:	876	Species:	Xenopus tropicalis

Alignment Length:	904	Identity:	256/904 - (28%)
Similarity:	425/904 - (47%)	Gaps:	116/904 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 RDKKWP-----WFGAPIYAAAAFALFYAAVLPSFYSYPKMLYQSEEAL-----HPDKFIGERAMR 72
            |:||.|     .|||   |.....|.|...:..      :::.|...|     |...|....|..
Frog    32 REKKKPRQLDGGFGA---AVPVLLLLYVLGVRG------LVHISLRQLVTPGGHSTGFNASTARE 87

  Fly    73 QLAEYSAIGNKMSGSINNEVHTINFLLREIQKIKDEARLDLYDIEVDTQYSSGAF---HLWGMTI 134
            .|.:.::|.:::.||..||:..:::||.:|:.|:::.. .::.|.||.|..:|.|   .|.|.|.
Frog    88 YLQQITSIDSRIVGSPENEIIAVDYLLGKIKDIEEKVN-SVHKITVDVQRPTGTFSIDFLGGFTS 151

  Fly   135 SYTNLSNVVVKISQKSSDNENYLLVNSHYDSEVQTPAAGDDGVMVVVMLETLRVISRSERTLTHP 199
            .|.|::|:.||: :.....|:.:|.|.|:||...||.|.||.|...||||.|..:|.|.:.|.|.
Frog   152 YYDNITNIAVKL-EPEFGAEHAVLANCHFDSVANTPGASDDAVSCAVMLEILGSLSVSSKPLRHA 215

  Fly   200 VVFLFNGAEEACMLGSHGFITQHKWSKNCKALVNLDSTGAGGREVLFQTGPNHPWLAKYYQASVP 264
            ::||||||||..:.|||||||||.|:|..:|.:||::.|.||:|::|||||.:|||.:.|..:..
Frog   216 IIFLFNGAEENILQGSHGFITQHPWAKMVRAFINLEAAGVGGKELVFQTGPENPWLVQAYALAAV 280

  Fly   265 HPYAQTLAEELFQHNFIPSDTDFRIFRDYGGVPGLDMASVMNGYVYHTEFDNFKNVEYGTYQSTG 329
            ||:|..:|:|:||...|||||||||:||:|.:||:|:|.:.|||:|||::|.:..:...:.|..|
Frog   281 HPFASVVAQEVFQSGIIPSDTDFRIYRDFGNIPGIDLAFIENGYIYHTKYDTWNRILTESIQRAG 345

  Fly   330 ENVLPLIWALANAPELDNTTAYEKGHTVYYDFLGWFMMTYTESVSIAINVVVSVAAFICIGTSVY 394
            :|:|.::..||.:.:|..::.:..|:.|::|..|.|:::|...:...||.:.:......||..:
Frog   346 DNILGVLHYLATSSQLAESSKFRHGNMVFFDVCGLFVLSYPARLGTIINYITAAVTLFYIGKKI- 409

  Fly   395 IMTLDNGADAPKAVVLRFAIIFLVQAGTLFVACGLTLLVAVFMQGVGLAESWYYGKWMAFGLYFC 459
            |.....|.:..:.:|..|.|..:.....|..    .|::||.:...|.|..||...:::..||..
Frog   410 IKYKQGGTNYARDLVYGFLITLVSWVSALVT----VLIIAVLVSLAGKALFWYTHFYVSVFLYGS 470

  Fly   460 --------------TLFFAFGILPATYIGFTKRKTNMKLDQTIACFMHAQCILLALLCIIMTIMG 510
                          |.|||..  .:.|:|              ..|.....|:..:..:::|..|
Frog   471 AAVAKLILVHSLAKTFFFAGA--SSQYLG--------------DVFFDISLIIWCIPLVLLTQSG 519

  Fly   511 IRSSYFPMVGIFFYAISVLVQIVLKLTLKKSY--------FVTVHLLFQVLPFFFYTYICYATLV 567
            :.|:|       |:|..::..::.||.|:...        |..::||....|:....|..:|...
Frog   520 LCSAY-------FFAAWIIFPLLTKLLLQPDIIHQGSPYKFTVIYLLGLFPPYLHTMYHVWAVFE 577

  Fly   568 TFVPMEGRDGPESSPDIMISVFIIATAINYAGFVIPIMHKFRKPKIIFSSFGVITIIFIILACTS 632
            .|.|:.||.|.|..||:::...|||..|....:.|..::..:..|.|.....|::::..:|.|:.
Frog   578 MFTPILGRSGTEIPPDVVLGFLIIACTIMLISYFISFIYLVKNTKNIIVPLAVLSVLTFLLVCSG 642

  Fly   633 AGFPFVKQL---APQRYYVLHTQRTFHNLDG-TSKQDSGYYIQPVD--------TRLHELDDTTF 685
            ..||:....   .|:|.::.||.||||:|.| ..|:|||.:|...|        ....||:||
Frog   643 MFFPYSSSTDSPKPKRIFLQHTTRTFHSLTGEVVKKDSGIWINGFDYTGISHVTPHFPELNDT-- 705

  Fly   686 KNAEPESWTAATCAAEPYCGLPLYSGRWIEWKDSARWIYSSPPV-IPMNINLTQLSKQSLDGNKV 749
                    ..|.|...|.||.|.|..  :.......|...:||. |..:.....:|::.:.....
Frog   706 --------VRAPCDDAPLCGFPWYFP--VHNLIRKNWYLPAPPAPIYEHTEFKLVSREEMSWGTT 760

  Fly   750 RYEYNLRASDRVMMYIDPLDNVKVTDWSF-DHTPLVEKHTPPYLIYA--IYSQTEEPLNFWVELE 811
            |..:..:....:.:|:.|..:..::.||. |..|:.......::.|:  :|:..   ..||:|::
Frog   761 RLHFEAKGPSHMTVYVRPHADSVLSSWSLGDGIPIASGEKDYFIFYSHGLYAPA---WKFWIEVK 822

  Fly   812 HEEGNTDGPYMKLVVSEHFQY-----HPEYYTEEYKEFLATFPDWTYTTDWFSALESWI 865
            :....:.| .:.:.|..|:.:     .|...|.|.|     ||||::.:.|....:.::
Frog   823 NSADESKG-IVTVAVGSHYFFGDSRNSPHLKTVELK-----FPDWSFPSSWVCTYDLYV 875

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10051	NP_611414.1	M28_Fxna_like	62..369	CDD:193497	124/309 (40%)
CG10051	NP_611414.1	MATE_like	361..>604	CDD:298879	58/264 (22%)
ermp1	XP_004910853.1	M28_Fxna_like	78..385	CDD:349872	124/308 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	234	1.000	Domainoid score	I2323
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H121891
Inparanoid	1	1.050	401	1.000	Inparanoid score	I1875
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D152011at33208
OrthoFinder	1	1.000	-	-		FOG0000591
OrthoInspector	1	1.000	-	-		otm47728
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1738
SonicParanoid	1	1.000	-	-		X435
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.090