DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10051 and NAALADL1

DIOPT Version :9

Sequence 1:	NP_611414.1	Gene:	CG10051 / 37222	FlyBaseID:	FBgn0034437	Length:	866	Species:	Drosophila melanogaster
Sequence 2:	NP_005459.2	Gene:	NAALADL1 / 10004	HGNCID:	23536	Length:	740	Species:	Homo sapiens

Alignment Length:	411	Identity:	86/411 - (20%)
Similarity:	147/411 - (35%)	Gaps:	135/411 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   115 DIEVDTQYSSGAFHLWGMTISYTNLSNVVVKISQKSSDNENYLLVNSHYDSEVQ---TPAAGDDG 176
            |...|:|.:...::    .:...|.|| |:.|.:.:.:.:.|:|..:|.||.|.   .|::|
Human   326 DFPADSQVNVSVYN----RLELRNSSN-VLGIIRGAVEPDRYVLYGNHRDSWVHGAVDPSSG--- 382

  Fly   177 VMVVVMLETLRVIS--------RSERTLTHPVVFLFNGAEEACMLGSHGFITQ--HKWSKNCKAL 231
              ..|:||..||:.        |..|:    :||...||||..::||..|..:  :|..:...|.
Human   383 --TAVLLELSRVLGTLLKKGTWRPRRS----IVFASWGAEEFGLIGSTEFTEEFFNKLQERTVAY 441

  Fly   232 VNLD-STGAGG----------REVLFQT-------GPN-----HPWLAKYYQASVPHPYAQTLAE 273
            :|:| |..|..          :.|:|..       ||.     ..|: :|:..|.|
Human   442 INVDISVFANATLRVQGTPPVQSVVFSATKEIRSPGPGDLSIYDNWI-RYFNRSSP--------- 496

  Fly   274 ELFQHNFIPS------DTDFRIFRDYGGVPGLDMA--------SVMNGYVYHTEFDNFKNVE--- 321
               .:..:||      .:|:..|..:.|:..:|:|        |......|||.||.|..|:
Human   497 ---VYGLVPSLGSLGAGSDYAPFVHFLGISSMDIAYTYDRSKTSARIYPTYHTAFDTFDYVDKFL 558

  Fly   322 ---YGTYQSTGENVLPLIWALANAPELDNTTAYEKGHTVYYDFLGWFMMTYTESV---------- 373
               :.::|:.......:|..|:::                 .||...:..|:|::
Human   559 DPGFSSHQAVARTAGSVILRLSDS-----------------FFLPLKVSDYSETLRSFLQAAQQD 606

  Fly   374 --------SIAIN-VVVSVAAFICIGTSV--YIMTLDNGADAPKAVVLRFAIIFLVQAGTLFVAC 427
                    ||::. :|.:|..|.....::  .|.||..|:..|..|.:              :..
Human   607 LGALLEQHSISLGPLVTAVEKFEAEAAALGQRISTLQKGSPDPLQVRM--------------LND 657

  Fly   428 GLTLLVAVFMQGVGLAESWYY 448
            .|.||...|:......|..||
Human   658 QLMLLERTFLNPRAFPEERYY 678

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10051	NP_611414.1	M28_Fxna_like	62..369	CDD:193497	66/309 (21%)
CG10051	NP_611414.1	MATE_like	361..>604	CDD:298879	22/109 (20%)
NAALADL1	NP_005459.2	Zinc_peptidase_like	46..>121	CDD:387401
		PA_GCPII_like	109..335	CDD:239036	3/8 (38%)
		M28_PSMA_like	<348..587	CDD:349942	61/278 (22%)
		TFR_dimer	616..735	CDD:367885	17/77 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2234
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900