DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11961 and PFF1

DIOPT Version :9

Sequence 1:	NP_001246418.1	Gene:	CG11961 / 37221	FlyBaseID:	FBgn0034436	Length:	891	Species:	Drosophila melanogaster
Sequence 2:	NP_009630.3	Gene:	PFF1 / 852366	SGDID:	S000000278	Length:	976	Species:	Saccharomyces cerevisiae

Alignment Length:	1038	Identity:	205/1038 - (19%)
Similarity:	359/1038 - (34%)	Gaps:	312/1038 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 LLLYVTISIPAC-----HRLPRPLTIQDEETHPD-QFIAERAEKNLRELVSLGPRVVGSRQNEMA 122
            |||.:|.||...     |...: |.:..|:.||: ..:.|.|..:| ::::.......|::|:
Yeast    20 LLLLITYSIITLLYIFDHERYK-LNLPKEDEHPEFNDLLETAWGDL-QIITASFHPYTSKEND-- 80

  Fly   123 ALKMLSQKMQKIRSGTANDIEVDV--------------QVASGSYVHWSMVNMYQSIQNIVVKIS 173
              |:....::::...|.|.....|              |........:|.|..::| .||:||:.
Yeast    81 --KVHDYLLKRVLEITGNSSFASVSDDKESERSILFQQQDPFNESSRFSRVTYFES-SNILVKLE 142

  Fly   174 PKNTNSTTYLLVNSHYDSVPAGPGAGDDGSMVATMMEVLRVLAKSDKPLKNPVVFLFNGAEENPL 238
            .||..... ||:::|:||||.|.||.|||..|.:::..|:...| .:| ...::|.||..||..|
Yeast   143 GKNPEEEG-LLLSAHFDSVPTGYGATDDGMGVVSLLANLKYHIK-HRP-NRTLIFNFNNNEEFGL 204

  Fly   239 QASHAFITQHKWAKYCKALINLDSCGNGGREILFQSGPNHPWLMKNYRRAIK-HPYASTMGEELF 302
            ..:..:. .|.|:...|.:|||:..|.||:.:||::....  ..:.|::::| :|:.:::.::.|
Yeast   205 LGASTYF-DHSWSNLTKYVINLEGTGAGGKAVLFRTSDTS--TARIYQQSVKENPFGNSIYQQGF 266

  Fly   303 QHNFIPSDTDFRIFRDHGSVPGLDMAYTYNGFVYHTRHDKAEIFPRGSFQHTGDNLLALVRQIAN 367
            ...::.|:||::|:.::| :.|.|:|:.....:|||..|..:...:.|..|.....|.|...:|:
Yeast   267 YSRYVRSETDYKIYEENG-MRGWDVAFYKPRNLYHTIKDSIQYTSKASLWHMLHTSLQLSAYVAS 330

  Fly   368 SPEIENSAKYA-KGHTIYFDVMG--WFLV-----FYTETEGVILNVIVSLVSIGICGY------- 417
                 ||...| :....|||.:|  :|::     ||.   ..|..::..:|:||:  |
Yeast   331 -----NSLDTADQTPACYFDFIGLKFFVISAKTLFYW---NCIFLLVSPVVAIGL--YLISRDRM 385

  Fly   418 AFKLMSVNSGIKLEKILKKVGHTLLVQILSVVVGAILPVLLGLFMDAVHL-PLSWFSNSWLILGL 481
            .:|..|..|..:..              ||:..|.|:..|..  .|.:.. ||::..|.:..:..
Yeast   386 TWKSYSWLSWTRFP--------------LSLAAGIIVQKLFS--NDIIRSNPLTFSRNYFWPISA 434

  Fly   482 YFT-------------TFFF------GLAIVPALYFHWTKRDKLPIGQRVQLLLHCHCLL----- 522
            :||             .|||      .|:|:......||            :||....||
Yeast   435 FFTQVIFTSYVLINCSNFFFPCADMKSLSIIELFIILWT------------ILLFTSKLLYSSDY 487

  Fly   523 -------LSVLTLIFTICGIRSVFVLML----------SCLFY---------------------- 548
                   ||:..|:.||..|..:..|.|          .|..:
Yeast   488 RYTGLYPLSIFFLLSTIAAILRLLALALGMRTRKRLGRECRDHHSNYSSHSQIDMERDGQENLEQ 552

  Fly   549 -----------------------TVGLIINI---------------------------------- 556
                                   :.|...|:
Yeast   553 PQDQLTSSQDDQASIQDDNVSTTSAGPSHNVDEDHGMDSSSQQHDERVPLLKGSNSMEEGLSTRE 617

  Fly   557 -ATKLHTKDVAWVIPH-IVCTVPPFVFF-------AYFSH----GFFTTF-IPMFGRFGENLNPD 607
             :.||...|.||:|.. ::..:|.|:.|       ...:|    |...|| :..||..|..|
Yeast   618 NSLKLEYTDYAWIIQFLLIVPIPSFILFNSVDVIMDALNHTVQEGSKATFDVLRFGMVGSIL--- 679

  Fly   608 LAVAVFSVAVGFLCCGFIIPVLQLFNKSKTIICGLMGITLLCFIIAMTPIGFPYRPETNVQRFAV 672
                            ..:|:|..|.|...|   .:.:|.|.|:|:.:.. ....|.||.....|
Yeast   680 ----------------IALPILPFFYKVNYI---TISLTALLFLISASKT-LLVHPFTNSNPLKV 724

  Fly   673 LHTKRTFHDAQNKVRRQ---ESGYFIMP--QDRRTYTVKNAVINMTLAQR--------------I 718
            ..::.......|.....   ..|.|:.|  ||..:....:..||.|....              :
Yeast   725 RFSQNIDLSQGNAASVHVLGREGNFLKPMLQDLPSIKYSSTHINCTSVTNGMELCMYDGMQPNLL 789

  Fly   719 GSDCDKEINCGLP---LYNQRWHKTRKNSLWIPASEPVLG-------ENVPTVLLLSKNTVSPTK 773
            .::.:..|:..:.   |:|.|      ||......||::.       ||....|.......:.:.
Yeast   790 STNGNTNISSMVKVHVLHNNR------NSTERSPYEPIVAELLLEVKENRACTLTFESRHQAKSP 848

  Fly   774 IR----YEMQLSGPNHMALFIQPLNGAKMMDWSFHQAPLRLSF-EPPYFIYFSW--------GVN 825
            :|    |:.:.|.|....:.....:.:.:.:...|    :|.| :..|.|...|        .|.
Yeast   849 VREITVYQKKNSAPQKANITKTIKSASGINELQLH----KLDFDQETYHIGVQWFPKLLTDGNVE 909

  Fly   826 GDPLKFWLELEKPNGNWNSSTLELGLGGHWNHH--KELITPDFKKFLDSFPHYVDATPWPASF 886
            .|.|            .....|.:.:..:|..:  :.::.....:.:.:|...::..|...||
Yeast   910 DDKL------------GTKDELSVSISCYWGEYDSESVVNGTAVRKIPAFDELINYAPLSFSF 960

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11961	NP_001246418.1	M28_Fxna_like	91..395	CDD:193497	83/327 (25%)
PFF1	NP_009630.3	M28_Fxna_like	50..354	CDD:349872	84/321 (26%)
PFF1	NP_009630.3	DUF2189	366..>443	CDD:413262	18/94 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157343306
Domainoid	1	1.000	99	1.000	Domainoid score	I1571
eggNOG	1	0.900	-	-		E1_COG2234
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000591
OrthoInspector	1	1.000	-	-		otm46574
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12147
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1738
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.870