DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG11961 and Tfrc

DIOPT Version :10

Sequence 1:NP_725876.1 Gene:CG11961 / 37221 FlyBaseID:FBgn0034436 Length:891 Species:Drosophila melanogaster
Sequence 2:NP_073203.1 Gene:Tfrc / 64678 RGDID:70488 Length:761 Species:Rattus norvegicus


Alignment Length:616 Identity:118/616 - (19%)
Similarity:202/616 - (32%) Gaps:171/616 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly    60 FGFWLLLYVTISIPACHRLPRPLTIQDEETHPDQFIA----ERAEKNLRELVSLGPR-------- 112
            ||...|.|...|:..        .:..:.:|.:..:|    |.|:.|::..|....|        
  Rat    13 FGGEPLSYTRFSLAR--------QVDGDNSHVEMKLAADEEENADSNMKASVRKPKRFNGRLCFA 69

  Fly   113 --------VVGSRQNEMAALKMLSQKMQKIRSGTANDIEVDVQ-----VASGSYVHWSMVN--MY 162
                    ::|.....:...|.:.||.:.:|...|.:.:....     |...|.:.|:.:.  :.
  Rat    70 TIAVVIFFLIGFMIGYLGYCKRVEQKEECVRLAEAEEADKSENDETEYVPKSSRLFWADLKTLLS 134

  Fly   163 QSIQNIVVKISPKNTNSTTYLLVNSHYDSVPAGPGAGDDGSMVATMMEVLRVLAKSDK------- 220
            :.:.:|......|..:..||         .|...|:..|.:: |..:|.|....|..|       
  Rat   135 EKLNSIEFTDIIKQLSQNTY---------TPREAGSQKDENL-AYYIENLFHDFKFSKVWRDEHY 189

  Fly   221 ---PLKNPV----VFLFNGAEENPLQASHAFITQHKWAKYCKALINLDSCGNGGREILFQSGPNH 278
               .:||.|    |.:.:|:..:|::|...::...|..:....|::    .|.|.:..|:.    
  Rat   190 VKIQVKNSVSQNLVTINSGSNIDPVEAPEGYVAFSKAGEVTGKLVH----ANFGTKKDFEE---- 246

  Fly   279 PWLMKNYR--------RAIKHPYASTMGEELFQHNFIPSDTDFRIFRDHGSVPGLDMAYTYNGFV 335
                .||.        ||.|..:|..:..   ..:|  :.....|:.|..:.|.::....:.|  
  Rat   247 ----LNYSVNGSLVIVRAGKITFAEKVAN---AQSF--NAIGVLIYMDRNTFPVVEADLQFFG-- 300

  Fly   336 YHTRHDKAEIFPRG--SFQHT------GDNLLALVRQIANSPEIENSAKYAKGHTIYFDVMGWFL 392
             |......:.:..|  ||.||      ...|.::..|..:....|...|..:|:.    ...|  
  Rat   301 -HAHLGTGDPYTPGFPSFNHTQFPPSQSSGLPSIPVQTISRAAAEKLFKNMEGNC----PPSW-- 358

  Fly   393 VFYTETEGVILNVIVSLVSIGICGYAFKL-MSVNSGIKL--EKILKKVGHTLLVQILSVVVGAIL 454
                       |:..|      |    || :|.|..:||  ..:||:   |.::.|..|:.|...
  Rat   359 -----------NIDSS------C----KLELSQNQNVKLTVNNVLKE---TRILNIFGVIKGYEE 399

  Fly   455 P---VLLGLFMDAVHLPLSWFSNSW--------------LILGLYFTTFFFGLAIVPA---LYFH 499
            |   :::|...||           |              |.|...|:.........|:   ::..
  Rat   400 PDRYIVVGAQRDA-----------WGPGVAKSSVGTGLLLKLAQVFSDMISKDGFRPSRSIIFAS 453

  Fly   500 WTKRDKLPIGQRVQL---LLHCHCLLLSVLTLIFTICGIRSVFVLMLSCLFYT-VGLIIN----- 555
            ||..|...:|....|   |...|....:.:.|...:.| .|.|.:..|.|.|| :|.|:.     
  Rat   454 WTAGDYGAVGATEWLEGYLSSLHLKAFTYINLDKVVLG-TSNFKVSASPLLYTLMGKIMQDVKHP 517

  Fly   556 IATKLHTKDVAWV--IPHIVCTVPPFVFFAY 584
            |..|...:|..|:  |..:......|.|.||
  Rat   518 IDGKYLYRDSNWISKIEELSLDNAAFPFLAY 548

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG11961NP_725876.1 M28_Fxna_like 91..395 CDD:349872 62/360 (17%)
MFS <539..>658 CDD:475125 16/54 (30%)
TfrcNP_073203.1 Mediates interaction with SH3BP4. /evidence=ECO:0000250|UniProtKB:P02786 1..67 12/61 (20%)
Endocytosis signal. /evidence=ECO:0000250|UniProtKB:P02786 20..23 1/2 (50%)
Stop-transfer sequence. /evidence=ECO:0000250|UniProtKB:P02786 58..61 0/2 (0%)
PA_TfR 201..378 CDD:239043 41/223 (18%)
M28_TfR 386..611 CDD:349946 38/175 (22%)
Ligand-binding. /evidence=ECO:0000250 570..761
TFR_dimer 638..751 CDD:461238
Cell attachment site, required for binding to transferrin. /evidence=ECO:0000250|UniProtKB:P02786 647..649
Blue background indicates that the domain is not in the aligned region.

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