DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11961 and Ermp1

DIOPT Version :9

Sequence 1:	NP_001246418.1	Gene:	CG11961 / 37221	FlyBaseID:	FBgn0034436	Length:	891	Species:	Drosophila melanogaster
Sequence 2:	XP_006231303.1	Gene:	Ermp1 / 373544	RGDID:	727831	Length:	899	Species:	Rattus norvegicus

Alignment Length:	890	Identity:	264/890 - (29%)
Similarity:	447/890 - (50%)	Gaps:	59/890 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 RPRGSQQYEAQPNGCERAFVQGNKIKWFWAPAFFGFWLLLYVTISIPACHRLPRPLTIQDEETHP 91
            |.||..:...:..|.:.|.   ::.:...|.|.:...|...|.:|:... .|.|...:|.|
  Rat    44 RMRGRTESGGESRGAKTAL---SEARTALALALYLLALRALVQLSLQRL-VLSRTSGLQGE---- 100

  Fly    92 DQFIAERAEKNLRELVSLGPRVVGSRQNEMAALKMLSQKMQKI--RSGTANDIEVDVQVASGSY- 153
              |.|.:|...|..:.::|||..||.:||:..::.|.:::..|  :|.:.:.|.||||..:||:
  Rat   101 --FDARQARVYLEHITAIGPRTTGSAENEILTVQYLLEQITLIEEQSNSLHRISVDVQRPTGSFS 163

  Fly   154 --VHWSMVNMYQSIQNIVVKISPKNTNSTTYLLVNSHYDSVPAGPGAGDDGSMVATMMEVLRVLA 216
              ......:.|.:|.|:|||:.|:: .:...:|.|.|:|||...|||.||....|.|:|||||:|
  Rat   164 IDFLGGFTSYYDNITNVVVKLEPQD-GAKYAVLANCHFDSVANSPGASDDAVSCAVMLEVLRVMA 227

  Fly   217 KSDKPLKNPVVFLFNGAEENPLQASHAFITQHKWAKYCKALINLDSCGNGGREILFQSGPNHPWL 281
            .|.:||::.|||||||||||.|||||.|||||.||...:|.|||::.|.||:|::||:||.:|||
  Rat   228 ASPEPLQHAVVFLFNGAEENVLQASHGFITQHPWASLIRAFINLEAAGVGGKELVFQTGPENPWL 292

  Fly   282 MKNYRRAIKHPYASTMGEELFQHNFIPSDTDFRIFRDHGSVPGLDMAYTYNGFVYHTRHDKAEIF 346
            ::.|..|.|||:||.:.:|:||...|||||||||:||.|::||:|:|:..||::|||::|.|:..
  Rat   293 VQAYVSAAKHPFASVVAQEVFQSGIIPSDTDFRIYRDFGNIPGIDLAFIENGYIYHTKYDTADRI 357

  Fly   347 PRGSFQHTGDNLLALVRQIANSPEIENSAKYAKGHTIYFDVMGWFLVFYTETEGVILNVIVSLVS 411
            ...|.|..|||:||:::.:|.|..:.:|::|..|..::|||:|..::.|....|.|:|.:|.:..
  Rat   358 LIDSIQRAGDNILAVLKYLATSDMLASSSEYRHGSMVFFDVLGLLVIAYPSRVGSIINYMVVMAV 422

  Fly   412 IGICGYAFKLMSVNSGIKLEKILKKVGHTLLVQILSVVVGAILPVLLGLFMDAVHLPLSWFSNSW 476
            :...|.........:...:...|..:|.|.:....|:|...|:.|    |:..:...|||::..:
  Rat   423 VLYLGRKLLRPKHRNSNYVRDFLCGLGITFISWFTSLVTVLIIAV----FVSLIGQSLSWYNYFY 483

  Fly   477 LILGLYFTTFFFGLAIVPAL--YFHWTKRDKLPIGQ---RVQLLLHCHCLLLSVLTLIFTICGIR 536
            :.:.||.|.....:.::..|  .|::.....|.:|:   ...|.:||..|      :..|..|..
  Rat   484 IAVCLYGTATVAKIILIHTLAKRFYYVNASDLYLGELFFDTSLFVHCGFL------VALTAQGFC 542

  Fly   537 SVFVLMLSCLFYTVGLIINIAT----KLHTKDVAWVIPHIVCTVPPFVFFAYFSHGFFTTFIPMF 597
            |.|   :|.::....|:..:..    |.|.....::..:::....|:::..|.....|..|.|:.
  Rat   543 SAF---MSAVWVAFPLLTKLCVYKDFKKHGAKGRFIALYLLGMFIPYLYGLYLIWAVFEMFTPIL 604

  Fly   598 GRFGENLNPDLAVAVFSVAVGFLCCGFIIPVLQLFNKSKTIICGLMGITLLCFIIAMTPIGFPY- 661
            ||.|..:.||:.:|........:...:.|..:.|.|.:|..|..|:.:..:.|::..:...|||
  Rat   605 GRSGSEIPPDVVLASILAVCVMILSSYFITFIYLVNSTKKTILTLILVCAVTFLLVCSGAFFPYS 669

  Fly   662 -RPET-NVQRFAVLHTKRTFHDAQNKVRRQESGYFIMPQDRRTYTVKNAV------INMTLAQRI 718
             .|:: ..:|..:.|..||||:.:..|.:::||.:|...|   ||..:.|      ||.|    |
  Rat   670 SNPDSPKPKRVFLQHVSRTFHNLEGSVVKRDSGIWINGFD---YTGMSHVTPHIPEINDT----I 727

  Fly   719 GSDCDKEIN-CGLPLYNQRWHKTRKNSLW-IPASEPVLGENVPTVLLLSKNTVSPTKIRYEMQLS 781
            .:.|::... ||.|.|.......|||  | :||.| :...|.....|:||..:....|:...:.:
  Rat   728 RAHCEENAPLCGFPWYLPVHFLIRKN--WYLPAPE-ISPRNPAHFRLVSKEKMPWDSIKLTFEAT 789

  Fly   782 GPNHMALFIQPLNGAKMMDWSFHQAPLRLSFEPPYFIYFSWGVNGDPLKFWLELEKPNGNWNSST 846
            ||:||:.:::...|:.:..||........|....||:::|.|:.....:||:|:::.:.......
  Rat   790 GPSHMSFYVRTHKGSTLSQWSLGNGIPVTSRGGDYFVFYSHGLQASAWQFWIEVQQVSEEQPEGM 854

  Fly   847 LELGLGGHWNHHKELITPDFKKFLDSFPHYVDATPWPASFESRIF 891
            :.:.:..|:...:...:.......:.||.:...:.|.:::...:|
  Rat   855 VTVAIAAHYLSGENKRSSQLDALKEKFPDWSFPSAWVSTYSLFVF 899

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11961	NP_001246418.1	M28_Fxna_like	91..395	CDD:193497	137/308 (44%)
Ermp1	XP_006231303.1	M28_Fxna_like	99..406	CDD:193497	138/313 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166339534
Domainoid	1	1.000	242	1.000	Domainoid score	I2158
eggNOG	1	0.900	-	-		E1_COG2234
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H121891
Inparanoid	1	1.050	417	1.000	Inparanoid score	I1759
OMA	1	1.010	-	-		QHG59376
OrthoDB	1	1.010	-	-		D152011at33208
OrthoFinder	1	1.000	-	-		FOG0000591
OrthoInspector	1	1.000	-	-		otm44686
orthoMCL	1	0.900	-	-		OOG6_101747
Panther	1	1.100	-	-	O	PTHR12147
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X435
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.770