DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11961 and CG10062

DIOPT Version :9

Sequence 1:	NP_001246418.1	Gene:	CG11961 / 37221	FlyBaseID:	FBgn0034436	Length:	891	Species:	Drosophila melanogaster
Sequence 2:	NP_001261089.1	Gene:	CG10062 / 37224	FlyBaseID:	FBgn0034439	Length:	868	Species:	Drosophila melanogaster

Alignment Length:	861	Identity:	418/861 - (48%)
Similarity:	586/861 - (68%)	Gaps:	29/861 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 KIKWFWAPAFFGFWLLLYVTISIPACHRLPRPLTIQDEETHPDQFIAERAEKNLRELVSLGPRVV 114
            |::|::|||||||||:||:::.....:.:|||||..||.:||:.|||:|||..|.||..:|||||
  Fly    18 KLQWYYAPAFFGFWLVLYLSLVNTQMNHMPRPLTRSDEASHPNSFIAQRAEDTLIELTRIGPRVV 82

  Fly   115 GSRQNEMAALKMLSQKMQKIRSGTAN--DIEVDVQVASGSYVHWSMVNMYQSIQNIVVKISPKNT 177
            ||..||.:|::.|..::.|:.|..::  :||||||.|||:|:||.||||||.|||:|||:|.||:
  Fly    83 GSMANEESAVEFLRAEVAKVESEMSDLLEIEVDVQQASGAYMHWEMVNMYQGIQNVVVKLSEKNS 147

  Fly   178 NSTTYLLVNSHYDSVPAGPGAGDDGSMVATMMEVLRVLAKSDKPLKNPVVFLFNGAEENPLQASH 242
            .:..|||:||||||||..||||||||||.||:||:||:|||..||.:|:||||||||||||||||
  Fly   148 TNENYLLINSHYDSVPGSPGAGDDGSMVVTMLEVMRVIAKSGDPLAHPIVFLFNGAEENPLQASH 212

  Fly   243 AFITQHKWAKYCKALINLDSCGNGGREILFQSGPNHPWLMKNYRRAIKHPYASTMGEELFQHNFI 307
            ||||||||||.|||||||||.|:||||||||||||||||| ||.|.:.||:|:|:.|||||..:|
  Fly   213 AFITQHKWAKNCKALINLDSAGSGGREILFQSGPNHPWLM-NYYRNVPHPFANTLAEELFQAGYI 276

  Fly   308 PSDTDFRIFRDHGSVPGLDMAYTYNGFVYHTRHDKAEIFPRGSFQHTGDNLLALVRQIANSPEIE 372
            |||||||||||:|.||||||||.:||:||||::::...|||.||||||||:|:|.|.:||:||::
  Fly   277 PSDTDFRIFRDYGGVPGLDMAYIFNGYVYHTKYNRINAFPRASFQHTGDNVLSLARALANAPELD 341

  Fly   373 NSAKYAKGHTIYFDVMGWFLVFYTETEGVILNVIVSLVSIGICGYAFKLMSVNSGIKLEKILKKV 437
            ::|.:::||.|::|.:|||::|||||..:|:||:|:|:::...|.:...||:.||...:.:|.:.
  Fly   342 DTAAHSEGHNIFYDFLGWFMIFYTETTSIIVNVVVTLLALLGVGISIYFMSLRSGCSWKGVLLRF 406

  Fly   438 GHTLLVQILSVVVGAILPVLLGLFMDAVHLPLSWFSNSWLILGLYFTTFFFGLAIVPALYFHWTK 502
            ..::.:|.:|:::...|.:|:.||||.|...:|||::||.|.|||.....|||:|:||||...||
  Fly   407 SISIAIQFVSLILAIGLALLVALFMDGVDRSMSWFTSSWTIFGLYLAPIVFGLSILPALYLEKTK 471

  Fly   503 RDKLPIGQRVQLLLHCHCLLLSVLTLIFTICGIRSVFVLMLSCLFYTVGLIINIATKLHTKDVAW 567
            ||.|.:|.|:||.:|.||:.|.|:.|..|...|||.:::||..||..|.||:|:.||.|.|...:
  Fly   472 RDPLGLGFRIQLFMHSHCICLIVIMLTLTGLSIRSAYLIMLCILFDIVALIVNLVTKWHRKAYLF 536

  Fly   568 VIPHIVCTVPPFVFFAYFSHGFFTTFIPMFGRFGENLNPDLAVAVFSVAVGFLCCGFIIPVLQLF 632
            .|...||.:.|.|||.|.......|.:||.||.|.:.|||:.:|........:..|||.|::..|
  Fly   537 AIAVTVCQILPLVFFTYLCTVALVTLMPMQGRSGSSTNPDMVIAALVWLFSLMFAGFIAPLIMFF 601

  Fly   633 NKSKTIICGLMGITLLCFIIAMTPIGFPYRPETNVQRFAVLHTKRTFHDAQNKVRRQESGYFIMP 697
            .|::||:...:|||:|..|||:|..||||:.:|:.||::::|..|..|:|....|..|||.:|.|
  Fly   602 RKTRTIVLCFLGITILFIIIAVTNAGFPYKEKTSPQRYSLIHAHRRLHNADGSTRIDESGLYIYP 666

  Fly   698 QDRRTYTVKNAVINMTLAQRIGSDCDKEINCGLPLYNQRWHKTRKNSLWIPASEPVLGENVPT-- 760
            ||||....|:.:..:..|.::...||:|:.||:||||.||:|.|:.|:||..||   ...:||
  Fly   667 QDRRFGIAKDNIAAIGEAHQVSDFCDEEMFCGMPLYNHRWNKARQYSMWIETSE---SPEIPTEY 728

  Fly   761 ---VLLLSKNTVSPTKIRYEMQLSGPNHMALFIQPLNGAKMMDWSFHQAPLRLSFEPPYFIYFSW 822
               ||..|....:..:.|:...|:||:||.:||...|.|::::|||:...:|...||||.:|||:
  Fly   729 PMLVLQDSSELETSAQRRFNFTLAGPSHMGIFINVKNDARILNWSFNDTLIREQAEPPYMVYFSY 793

  Fly   823 GVNGDPLKFWLE------LEKPNGNWNSSTLELGLGGHWNHHKELITPD------FKKFLDSFPH 875
            |::..||:|.::      |:|....:::.|||:|:||||      :|.|      ...:::.||.
  Fly   794 GLDDSPLEFTIDVELNDYLQKTTSTFDTPTLEIGIGGHW------VTQDITAIEKLSSYINRFPS 852

  Fly   876 YVDATPWPASFESRIF 891
            |.....|..::|:..|
  Fly   853 YAYIQGWVGTYETWYF 868

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11961	NP_001246418.1	M28_Fxna_like	91..395	CDD:193497	201/305 (66%)
CG10062	NP_001261089.1	M28_Fxna_like	59..364	CDD:193497	201/305 (66%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45446908
Domainoid	1	1.000	161	1.000	Domainoid score	I1255
eggNOG	1	0.900	-	-		E1_COG2234
Homologene	1	1.000	-	-		H121891
Inparanoid	1	1.050	212	1.000	Inparanoid score	I1244
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D14040at33392
OrthoFinder	1	1.000	-	-		FOG0000591
OrthoInspector	1	1.000	-	-		otm25001
orthoMCL	1	0.900	-	-		OOG6_101747
Panther	1	1.100	-	-	P	PTHR12147
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X435
	12	11.800