DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11961 and NAALADL2

DIOPT Version :9

Sequence 1:	NP_001246418.1	Gene:	CG11961 / 37221	FlyBaseID:	FBgn0034436	Length:	891	Species:	Drosophila melanogaster
Sequence 2:	XP_011510914.1	Gene:	NAALADL2 / 254827	HGNCID:	23219	Length:	805	Species:	Homo sapiens

Alignment Length:	314	Identity:	69/314 - (21%)
Similarity:	121/314 - (38%)	Gaps:	73/314 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   116 SRQNEMAAL----------KMLSQKMQKIRSGTANDIEV---DVQVASGSYVHWSMVNMYQSIQN 167
            ||.|..:.|          |::|....:.::...:.:|:   :::|.|   :....|...:::.|
Human   380 SRSNLTSLLVQPISAPLVAKLISSPKARTKNEACSSLELPNNEIRVVS---MQVQTVTKLKTVTN 441

  Fly   168 IVVKISPKNTNSTTYLLVNSHYDSVPAGPGAGDDGSMVATMMEVLRVLAKSDKPLKNP---VVFL 229
            :|..:... |:...|::|.||:.:..:..|. :..|..|.:...:|.|....|....|   :||.
Human   442 VVGFVMGL-TSPDRYIIVGSHHHTAHSYNGQ-EWASSTAIITAFIRALMSKVKRGWRPDRTIVFC 504

  Fly   230 FNGAEENPLQASHAF--ITQHKWAKYCK--------ALINLDSCGNGGREILFQSGPNHPWLMKN 284
            ..|..        ||  |..::|.:..|        |.|:|.|...|...:...:.|:...|:..
Human   505 SWGGT--------AFGNIGSYEWGEDFKKVLQKNVVAYISLHSPIRGNSSLYPVASPSLQQLVVE 561

  Fly   285 YRRAIKHPYASTMGEELFQHNF----IPSDTDFRIFRDHGSVPGLDMAY----TYNG--FV---- 335
                 |:.:..|...:..:.|.    |..|.|:  |.:|..||.:..||    |..|  |:
Human   562 -----KNNFNCTRRAQCPETNISSIQIQGDADY--FINHLGVPIVQFAYEDIKTLEGPSFLSEAR 619

  Fly   336 YHTRHDK-AEIFPRGSFQHTGDNLLA-LVRQIANSP-----------EIENSAK 376
            :.||..| .|:.|..:...|...|.. ::.||||.|           |::|:.|
Human   620 FSTRATKIEEMDPSFNLHETITKLSGEVILQIANEPVLPFNALDIALEVQNNLK 673

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11961	NP_001246418.1	M28_Fxna_like	91..395	CDD:193497	69/314 (22%)
NAALADL2	XP_011510914.1	Peptidases_S8_S53	268..420	CDD:299169	7/39 (18%)
		Zinc_peptidase_like	437..659	CDD:301362	56/238 (24%)
		TFR_dimer	686..>744	CDD:282153
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2234
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900