DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11961 and CG30049

DIOPT Version :9

Sequence 1:	NP_001246418.1	Gene:	CG11961 / 37221	FlyBaseID:	FBgn0034436	Length:	891	Species:	Drosophila melanogaster
Sequence 2:	NP_725142.3	Gene:	CG30049 / 246416	FlyBaseID:	FBgn0050049	Length:	878	Species:	Drosophila melanogaster

Alignment Length:	858	Identity:	344/858 - (40%)
Similarity:	531/858 - (61%)	Gaps:	25/858 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 KIKWFWAPAFFGFWLLLYVTISIPACHRLPRPLTIQDEETHPDQFIAERAEKNLRELVSLGPRVV 114
            ::.|::||:|...|:.|:..|.:|..:|||..:|:.||...|.||:.|||:|.|.||..:||:||
  Fly    30 RLPWYYAPSFLLLWVALFYAIVLPLFYRLPDRVTMADEPLKPGQFVGERAQKILYELDRIGPKVV 94

  Fly   115 GSRQNEMAALKMLSQKMQKIRSGTAND---IEVDVQVASGSYVHWSMVNMYQSIQNIVVKISPKN 176
            ||..||:..:..|..:::||||....|   :|||||..:||||..:|.::||.|||:|||:|..:
  Fly    95 GSTANEVTTVAFLLNEVEKIRSEMRGDLFHLEVDVQQPTGSYVVGTMTSIYQGIQNVVVKLSTAS 159

  Fly   177 TNSTTYLLVNSHYDSVPAGPGAGDDGSMVATMMEVLRVLAKSDKPLKNPVVFLFNGAEENPLQAS 241
            :||::|||:|||:|:.|..|||||||:||..|:||||.::.|:....:|:|||||||||||||||
  Fly   160 SNSSSYLLINSHFDTKPGSPGAGDDGTMVVVMLEVLRQMSISESEFMHPIVFLFNGAEENPLQAS 224

  Fly   242 HAFITQHKWAKYCKALINLDSCGNGGREILFQSGPNHPWLMKNYRRAIKHPYASTMGEELFQHNF 306
            |.||||||||..|||:|||:..|||||:||||||||:|||:|.|::..|||:|||:.||:||...
  Fly   225 HGFITQHKWAPNCKAVINLEVGGNGGRDILFQSGPNNPWLVKYYKQHSKHPFASTLAEEIFQFGI 289

  Fly   307 IPSDTDFRIFRDHGSVPGLDMAYTYNGFVYHTRHDKAEIFPRGSFQHTGDNLLALVRQIANSPEI 371
            :|||||||||||:|::||||:|...||:||||..|..::.|..:.|:||:|:|:|||.::|:.|:
  Fly   290 LPSDTDFRIFRDYGNIPGLDIAQFSNGYVYHTAFDSFDVVPGRAVQNTGENILSLVRALSNASEL 354

  Fly   372 ENSAKYAKGHTIYFDVMGWFLVFYTETEGVILNVIVSLVSIGICGYAFKLMSVNSGIKLEKILKK 436
            .|:.:::.||.::||.:|.|.|.|||..|:|||...::.|:.:.|::...||..|.:...:|...
  Fly   355 YNTNEHSAGHAVFFDFLGLFFVTYTENTGIILNYCFAVASVFLVGFSLWRMSCVSEVSAGRISIL 419

  Fly   437 VGHTLLVQILSVVVGAILPVLLGLFMDAVHLPLSWFSNSWLILGLYFTTFFFGLAIVPALYFHWT 501
            ....|.:.:...::...||:::.:..|.....::::||:||::|||......||.:...||..:.
  Fly   420 FASHLGLHLAGCLLCIGLPLVMSILYDVSDRTMTYYSNNWLVIGLYICPAIIGLVLPSTLYHSFK 484

  Fly   502 KRDKLPIGQRVQLLLHCHCLLLSVLTLIFTICGIRSVFVLMLSCLFYTVGLIINIATKLHTKDVA 566
            ..||:....::.:.||.||::||:||:..|..|:|..::.|:|...|.:.|:||:.|.||.:...
  Fly   485 SDDKISHPYQMYVGLHAHCVVLSILTIALTAIGLRIPYMCMISLFLYILSLLINLLTTLHDRGYY 549

  Fly   567 WVIPHIVCTVPPFVFFAYFSHGFFTTFIPMFGRFGENLNPDLAVAVFSVAVGFLCCGFIIPVLQL 631
            ||:...:..:..:|:|.|..:.|...|.|..||..::.|||:.:|:......|...||::|::.:
  Fly   550 WVLTVQISQLFQYVYFCYLFYIFLVIFFPAMGRNRDSANPDMLIALICAVGTFFALGFVVPLINM 614

  Fly   632 FNKSKTIICGLMGITLLCFIIAMTPIGFPYRPETNVQRFAVLHTKRTFHDAQNKVRRQESGYFIM 696
            |..|..::..|..:|.:..:|::|.:||||||:|:|.|...|.|:|.|::....:...:|||:..
  Fly   615 FRWSTYLLICLGVVTFILSMISITGVGFPYRPKTSVMRVNFLQTRRMFYEYDGSLSVNDSGYYFD 679

  Fly   697 PQDRRTY-TVKNAVINMTLAQRIGSDCDKEINCGLPLYNQRWHKTRKNSLWIPASEPVLGENVPT 760
            .||||.. .:|:..:|:|....:...||:.:.||:|.:...|.:...::.|:|..|.|   .||.
  Fly   680 YQDRRALRPLKDYAVNLTGLTSVDGYCDRYVMCGIPCFWSSWCRGISSAAWLPRDEEV---TVPG 741

  Fly   761 VL---LLSKN-TVSPTKIRYEMQLSGPNHMALFIQPLNGAKMMDWSFHQAPLRL--SFEPPYFIY 819
            .|   .|:|. :.|.:..|:|.:|:||.||.|:|:||:|..:.||||.:..|..  .:.|||.||
  Fly   742 NLELNFLNKTLSKSGSSARFEFELAGPPHMGLYIRPLDGVAVEDWSFIRTMLDQPEKYSPPYQIY 806

  Fly   820 FSWGVNGDPLKFWLELEKPNGNWNSSTLELGLGGHWNHHKELITPDFK------KFLDSFPHYVD 878
            ||:||:..|.||.:|..|.:|..:....|||:.||:      :..||:      :|:...|.:|.
  Fly   807 FSYGVDSSPFKFHIEFVKSDGQLDGPIFELGVVGHY------VNQDFERDETTLRFIADLPDFVY 865

  Fly   879 ATPWPASFESRIF 891
            ...||:.|...||
  Fly   866 TMEWPSLFMRYIF 878

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11961	NP_001246418.1	M28_Fxna_like	91..395	CDD:193497	170/306 (56%)
CG30049	NP_725142.3	M28_Fxna_like	71..378	CDD:193497	170/306 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45446902
Domainoid	1	1.000	161	1.000	Domainoid score	I1255
eggNOG	1	0.900	-	-		E1_COG2234
Homologene	1	1.000	-	-		H121891
Inparanoid	1	1.050	212	1.000	Inparanoid score	I1244
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D14040at33392
OrthoFinder	1	1.000	-	-		FOG0000591
OrthoInspector	1	1.000	-	-		otm25001
orthoMCL	1	0.900	-	-		OOG6_101747
Panther	1	1.100	-	-	P	PTHR12147
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X435
	12	11.800