Protein Alignment CG11961 and Ermp1

DIOPT Version :10

• Sequence 1: NP_725876.1
• Gene: CG11961 / 37221
• FlyBaseID: FBgn0034436
• Length: 891
• Species: Drosophila melanogaster
• Sequence 2: NP_001349060.1
• Gene: Ermp1 / 226090
• MGIID: 106250
• Length: 899
• Species: Mus musculus
• Alignment Length: 829
• Identity: 256/829 - (30%)
• Similarity: 429/829 - (51%)
• Gaps: 59/829 - (7%)

  Fly    93 QFIAERAEKNLRELVSLGPRVVGSRQNEMAALKMLSQKMQKI--RSGTANDIEVDVQVASGSY-- 153
            :|.|.:|...|..:.::|||..||.:||:..::.|.::::.|  :|.:.:.|.||:|..:||:
Mouse   100 EFDARQARDYLEHITAIGPRTTGSTENEILTVQYLLEQIKLIEAQSNSLHSISVDIQRPTGSFSI 164

  Fly   154 -VHWSMVNMYQSIQNIVVKISPKNTNSTTYLLVNSHYDSVPAGPGAGDDGSMVATMMEVLRVLAK 217
             ......:.|.:|.|:|||:.|:: .:.:.:|.|.|:|||...|||.||....|.|:|||||::.
Mouse   165 DFLGGFTSYYDNITNVVVKLEPRD-GAESAILANCHFDSVANSPGASDDAVSCAVMLEVLRVMSA 228

  Fly   218 SDKPLKNPVVFLFNGAEENPLQASHAFITQHKWAKYCKALINLDSCGNGGREILFQSGPNHPWLM 282
            |.:|:::.|||||||||||.|||||.|||||.||...:|.|||::.|.||:|::||:||.:|||:
Mouse   229 SPEPMQHAVVFLFNGAEENVLQASHGFITQHPWASLIRAFINLEAAGVGGKELVFQTGPENPWLV 293

  Fly   283 KNYRRAIKHPYASTMGEELFQHNFIPSDTDFRIFRDHGSVPGLDMAYTYNGFVYHTRHDKAEIFP 347
            :.|..|.|||:||.:.:|:||...|||||||||:||.|::||:|:|:..||::|||::|.|:...
Mouse   294 QAYVSAAKHPFASVVAQEVFQSGIIPSDTDFRIYRDFGNIPGIDLAFIENGYIYHTKYDTADRIL 358

  Fly   348 RGSFQHTGDNLLALVRQIANSPEIENSAKYAKGHTIYFDVMGWFLVFYTETEGVILNVIVSLVSI 412
            ..|.|..|||:||:::.:|.|..:.:|::|..|..::|||:|..::.|....|.|:|.:|.:..:
Mouse   359 IDSIQRAGDNILAVLKHLATSDTLASSSEYRHGSMVFFDVLGLLVIAYPSRVGSIINYMVVMAVV 423

  Fly   413 GICGYAFKLMSVNSGIKLEKILKKVGHTLLVQILSVVVGAILPVLLGLFMDAVHLPLSWFSNSWL 477
            ...|.........:...:...|..:|.|.:....|:|...|:.|    |:..:...|||::..::
Mouse   424 LYLGKKLLRPKHRNANYMRDFLCGLGITFISWFTSLVTVLIIAV----FISLIGQSLSWYNYFYI 484

  Fly   478 ILGLYFTTFFFGLAIVPAL--YFHWTKRDKLPIGQ---RVQLLLHCHCLLLSVLTLIFTICGIRS 537
            .:.||.|.....:..:..|  .|::.....|.:|:   ...|.:||..|      :..|..|..|
Mouse   485 AVCLYGTATVAKIIFIHTLAKRFYYMNASDLYLGELFFDTSLFVHCAFL------VALTYQGFCS 543

  Fly   538 VFVLMLSCLFYTVGLIINIAT----KLHTKDVAWVIPHIVCTVPPFVFFAYFSHGFFTTFIPMFG 598
            .|   :|.::....|:..:..    |.|.....:|..:::....|:::..|.....|..|.|:.|
Mouse   544 AF---MSAVWVVFPLLTKLCVYKDFKKHGAQGRFVALYLLGMFIPYLYGLYLIWAVFEMFTPILG 605

  Fly   599 RFGENLNPDLAVAVFSVAVGFLCCGFIIPVLQLFNKSKTIICGLMGITLLCFIIAMTPIGFPY-- 661
            |.|..:.||:.:|........:...:.|..:.|.|.:|..|..|:.:..:.|::..:...|||
Mouse   606 RSGSEIPPDVVLASILAVCVMILSSYFITFIYLVNSTKKTILTLILVCAVTFLLVCSGAFFPYSS 670

  Fly   662 RPET-NVQRFAVLHTKRTFHDAQNKVRRQESGYFIMPQDRRTYTVKNAV------INMTLAQRIG 719
            .||: ..:|..:.|..||||:.:..|.:::||.:|...|   ||..:.|      ||.|    |.
Mouse   671 NPESPKPKRVFLQHVSRTFHNLEGSVVKRDSGIWINGFD---YTGMSHVTPHIPEINDT----IR 728

  Fly   720 SDCDKEIN-CGLPLYNQRWHKTRKNSLW-IPASEPVLGENVPTVLLLSKNTVSPTKIRYEMQLSG 782
            :.|:::.. ||.|.|.......|||  | :||.| |...|.....|:||..:....|:...:.:|
Mouse   729 AHCEEDAPLCGFPWYLPVHFLIRKN--WYLPAPE-VSPRNPAHFRLVSKEKMPWDSIKLTFEATG 790

  Fly   783 PNHMALFIQPLNGAKMMDWSFHQAPLRLSFEPPYFIYFSWGVNGDPLKFWLELEKPNGNWNSSTL 847
            |:||:.:::...|:.:..||........|....||:::|.|:.....:||:|:::.:.......:
Mouse   791 PSHMSFYVRTHKGSTLSQWSLGNGIPVTSRGGDYFVFYSHGLQASAWRFWIEVQQVSEEQAEGMV 855

  Fly   848 ELGLGGHW----NHHKELITPDFKKFLD-SFPHYVDATPWPASFESRIF 891
            .:.:..|:    |.....:....|||.| |||     :.|.:::...:|
Mouse   856 TVAIAAHYLSGENKRSSQLDALKKKFPDWSFP-----SAWVSTYSLFVF 899

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG11961	NP_725876.1	M28_Fxna_like	91..395	CDD:349872	134/306 (44%)
		MFS	<539..>658	CDD:475125	24/122 (20%)
Ermp1	NP_001349060.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..55
		M28_Fxna_like	99..406	CDD:349872	134/306 (44%)