DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11961 and Ermp1

DIOPT Version :9

Sequence 1:	NP_001246418.1	Gene:	CG11961 / 37221	FlyBaseID:	FBgn0034436	Length:	891	Species:	Drosophila melanogaster
Sequence 2:	NP_001349060.1	Gene:	Ermp1 / 226090	MGIID:	106250	Length:	899	Species:	Mus musculus

Alignment Length:	829	Identity:	256/829 - (30%)
Similarity:	429/829 - (51%)	Gaps:	59/829 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    93 QFIAERAEKNLRELVSLGPRVVGSRQNEMAALKMLSQKMQKI--RSGTANDIEVDVQVASGSY-- 153
            :|.|.:|...|..:.::|||..||.:||:..::.|.::::.|  :|.:.:.|.||:|..:||:
Mouse   100 EFDARQARDYLEHITAIGPRTTGSTENEILTVQYLLEQIKLIEAQSNSLHSISVDIQRPTGSFSI 164

  Fly   154 -VHWSMVNMYQSIQNIVVKISPKNTNSTTYLLVNSHYDSVPAGPGAGDDGSMVATMMEVLRVLAK 217
             ......:.|.:|.|:|||:.|:: .:.:.:|.|.|:|||...|||.||....|.|:|||||::.
Mouse   165 DFLGGFTSYYDNITNVVVKLEPRD-GAESAILANCHFDSVANSPGASDDAVSCAVMLEVLRVMSA 228

  Fly   218 SDKPLKNPVVFLFNGAEENPLQASHAFITQHKWAKYCKALINLDSCGNGGREILFQSGPNHPWLM 282
            |.:|:::.|||||||||||.|||||.|||||.||...:|.|||::.|.||:|::||:||.:|||:
Mouse   229 SPEPMQHAVVFLFNGAEENVLQASHGFITQHPWASLIRAFINLEAAGVGGKELVFQTGPENPWLV 293

  Fly   283 KNYRRAIKHPYASTMGEELFQHNFIPSDTDFRIFRDHGSVPGLDMAYTYNGFVYHTRHDKAEIFP 347
            :.|..|.|||:||.:.:|:||...|||||||||:||.|::||:|:|:..||::|||::|.|:...
Mouse   294 QAYVSAAKHPFASVVAQEVFQSGIIPSDTDFRIYRDFGNIPGIDLAFIENGYIYHTKYDTADRIL 358

  Fly   348 RGSFQHTGDNLLALVRQIANSPEIENSAKYAKGHTIYFDVMGWFLVFYTETEGVILNVIVSLVSI 412
            ..|.|..|||:||:::.:|.|..:.:|::|..|..::|||:|..::.|....|.|:|.:|.:..:
Mouse   359 IDSIQRAGDNILAVLKHLATSDTLASSSEYRHGSMVFFDVLGLLVIAYPSRVGSIINYMVVMAVV 423

  Fly   413 GICGYAFKLMSVNSGIKLEKILKKVGHTLLVQILSVVVGAILPVLLGLFMDAVHLPLSWFSNSWL 477
            ...|.........:...:...|..:|.|.:....|:|...|:.|    |:..:...|||::..::
Mouse   424 LYLGKKLLRPKHRNANYMRDFLCGLGITFISWFTSLVTVLIIAV----FISLIGQSLSWYNYFYI 484

  Fly   478 ILGLYFTTFFFGLAIVPAL--YFHWTKRDKLPIGQ---RVQLLLHCHCLLLSVLTLIFTICGIRS 537
            .:.||.|.....:..:..|  .|::.....|.:|:   ...|.:||..|      :..|..|..|
Mouse   485 AVCLYGTATVAKIIFIHTLAKRFYYMNASDLYLGELFFDTSLFVHCAFL------VALTYQGFCS 543

  Fly   538 VFVLMLSCLFYTVGLIINIAT----KLHTKDVAWVIPHIVCTVPPFVFFAYFSHGFFTTFIPMFG 598
            .|   :|.::....|:..:..    |.|.....:|..:::....|:::..|.....|..|.|:.|
Mouse   544 AF---MSAVWVVFPLLTKLCVYKDFKKHGAQGRFVALYLLGMFIPYLYGLYLIWAVFEMFTPILG 605

  Fly   599 RFGENLNPDLAVAVFSVAVGFLCCGFIIPVLQLFNKSKTIICGLMGITLLCFIIAMTPIGFPY-- 661
            |.|..:.||:.:|........:...:.|..:.|.|.:|..|..|:.:..:.|::..:...|||
Mouse   606 RSGSEIPPDVVLASILAVCVMILSSYFITFIYLVNSTKKTILTLILVCAVTFLLVCSGAFFPYSS 670

  Fly   662 RPET-NVQRFAVLHTKRTFHDAQNKVRRQESGYFIMPQDRRTYTVKNAV------INMTLAQRIG 719
            .||: ..:|..:.|..||||:.:..|.:::||.:|...|   ||..:.|      ||.|    |.
Mouse   671 NPESPKPKRVFLQHVSRTFHNLEGSVVKRDSGIWINGFD---YTGMSHVTPHIPEINDT----IR 728

  Fly   720 SDCDKEIN-CGLPLYNQRWHKTRKNSLW-IPASEPVLGENVPTVLLLSKNTVSPTKIRYEMQLSG 782
            :.|:::.. ||.|.|.......|||  | :||.| |...|.....|:||..:....|:...:.:|
Mouse   729 AHCEEDAPLCGFPWYLPVHFLIRKN--WYLPAPE-VSPRNPAHFRLVSKEKMPWDSIKLTFEATG 790

  Fly   783 PNHMALFIQPLNGAKMMDWSFHQAPLRLSFEPPYFIYFSWGVNGDPLKFWLELEKPNGNWNSSTL 847
            |:||:.:::...|:.:..||........|....||:::|.|:.....:||:|:::.:.......:
Mouse   791 PSHMSFYVRTHKGSTLSQWSLGNGIPVTSRGGDYFVFYSHGLQASAWRFWIEVQQVSEEQAEGMV 855

  Fly   848 ELGLGGHW----NHHKELITPDFKKFLD-SFPHYVDATPWPASFESRIF 891
            .:.:..|:    |.....:....|||.| |||     :.|.:::...:|
Mouse   856 TVAIAAHYLSGENKRSSQLDALKKKFPDWSFP-----SAWVSTYSLFVF 899

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11961	NP_001246418.1	M28_Fxna_like	91..395	CDD:193497	134/306 (44%)
Ermp1	NP_001349060.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..55
Ermp1	NP_001349060.1	M28_Fxna_like	99..406	CDD:193497	134/306 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167835897
Domainoid	1	1.000	247	1.000	Domainoid score	I2148
eggNOG	1	0.900	-	-		E1_COG2234
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H121891
Inparanoid	1	1.050	426	1.000	Inparanoid score	I1734
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG59376
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000591
OrthoInspector	1	1.000	-	-		otm42620
orthoMCL	1	0.900	-	-		OOG6_101747
Panther	1	1.100	-	-	O	PTHR12147
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X435
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.760