Protein Alignment EndoB and SH3GLB1

DIOPT Version :10

• Sequence 1: NP_611410.1
• Gene: EndoB / 37218
• FlyBaseID: FBgn0034433
• Length: 390
• Species: Drosophila melanogaster
• Sequence 2: XP_006710735.1
• Gene: SH3GLB1 / 51100
• HGNCID: 10833
• Length: 402
• Species: Homo sapiens
• Alignment Length: 412
• Identity: 169/412 - (41%)
• Similarity: 249/412 - (60%)
• Gaps: 41/412 - (9%)

  Fly     3 INLPNFNVKNLVKEAGSTISRVVQLTEEKLGTTERTEYDLHFQNLAERADVTKTWTEKIVRDTES 67
            :|:.:||||.|..:||:.:||.||.||||||..|:||.|.|.:||..:|:.||.|||||::.||.
Human     1 MNIMDFNVKKLAADAGTFLSRAVQFTEEKLGQAEKTELDAHLENLLSKAECTKIWTEKIMKQTEV 65

  Fly    68 VLIPNPQNRVEDFIFEKIEKSKPKRLSNLEHLALDMIEAGGDFGQDLPYGQALIKVGQAEQKLGQ 132
            :|.|||..|:|:|::||:::..|.|::|.|.|...||:||.:||....||.||||.|:.::::|.
Human    66 LLQPNPNARIEEFVYEKLDRKAPSRINNPELLGQYMIDAGTEFGPGTAYGNALIKCGETQKRIGT 130

  Fly   133 CEHDFIATSGICFTQPLRKFLDGEMKTIGKERGILETKRLDLDACKNRVKKAR------SMLGQQ 191
            .:.:.|.||.:.|..|||.|::|:.|||.|||.:|:.|||||||.|.|:|||:      |.|...
Human   131 ADRELIQTSALNFLTPLRNFIEGDYKTIAKERKLLQNKRLDLDAAKTRLKKAKAAETRNSQLNSA 195

  Fly   192 SKDG--------------------ISPEAVLEQAERDLRVAQAEFDRQAEITKLLLDGISTSQAS 236
            ..:|                    |..|.| .::|::||:.|:|||||||||:|||:|||::.|.
Human   196 RLEGDNIMVNFSYMLNFLHVKWLKIWAEEV-TKSEQELRITQSEFDRQAEITRLLLEGISSTHAH 259

  Fly   237 HLRHLHAFIQTQVRYYKQCGDVMEQLQRELANLGGPTPYIPLDVNEASASKSNISSGAAARGPGN 301
            |||.|:.|::.|:.||.||...|..||::|.:.  |:.|:.   |....|.:.:.|..    |..
Human   260 HLRCLNDFVEAQMTYYAQCYQYMLDLQKQLGSF--PSNYLS---NNNQTSVTPVPSVL----PNA 315

  Fly   302 NHSANMAAT-GHKPNQPMHVS----TDQMQRARVLCSYDAKDHTELNLSANEVIFVTECSPVNED 361
            ..|:.||:| |.....|.::|    ....::||||..|||.:.|||:|.|:|||.|.....::.|
Human   316 IGSSAMASTSGLVITSPSNLSDLKECSGSRKARVLYDYDAANSTELSLLADEVITVFSVVGMDSD 380

  Fly   362 YMYGKQGLLKGLVPRAFVEMLD 383
            ::.|::|..||.||..::|:|:
Human   381 WLMGERGNQKGKVPITYLELLN 402

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EndoB	NP_611410.1	BAR_Endophilin_B	26..266	CDD:153278	119/265 (45%)
		SH3_Endophilin_B	327..378	CDD:212736	23/50 (46%)
SH3GLB1	XP_006710735.1	BAR_Endophilin_B1	24..289	CDD:153300	119/265 (45%)
		SH3_Endophilin_B1	342..402	CDD:212878	24/59 (41%)