DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment EndoB and Sh3glb2

DIOPT Version :9

Sequence 1:	NP_611410.1	Gene:	EndoB / 37218	FlyBaseID:	FBgn0034433	Length:	390	Species:	Drosophila melanogaster
Sequence 2:	XP_006233878.1	Gene:	Sh3glb2 / 311848	RGDID:	1305886	Length:	454	Species:	Rattus norvegicus

Alignment Length:	457	Identity:	165/457 - (36%)
Similarity:	245/457 - (53%)	Gaps:	86/457 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 NFNVKNLVKEAGSTISRVVQLTEEKLGTTERTEYDLHFQNLAERADVTKTWTEKIVRDTESVLIP 71
            :||:|.|..:||...:|.||.||||.|..|:||.|.||:||..|||.||.|||:|:|.||.:|.|
  Rat     2 DFNMKKLASDAGIFFTRAVQFTEEKFGQAEKTELDAHFENLLARADSTKNWTERILRQTEVLLQP 66

  Fly    72 NPQNRVEDFIFEKIEKSKPKRLSNLEHLALDMIEAGGDFGQDLPYGQALIKVGQAEQKLGQCEHD 136
            ||..|||:|::||:::..|.|::|.|.||..|.||..:.|.:.|||:.|:||.:||::||..|.|
  Rat    67 NPSARVEEFLYEKLDRKVPSRVTNGELLAQYMAEAASELGPNTPYGKTLMKVSEAEKRLGAAERD 131

  Fly   137 FIATSGICFTQPLRKFLDGEMKTIGKERGILETKRLDLDACKNRVKKARSMLGQQSKDG------ 195
            ||.|:.:.|..|||.||:|:.|||.|||.:|:.:||||||||.|:|||::...:.:.:|
  Rat   132 FIHTASLSFLTPLRNFLEGDWKTISKERRLLQNRRLDLDACKARLKKAKAAEAKATCEGDTVPDF 196

  Fly   196 -----------------------------------------------ISPEAVL----------- 202
                                                           ::|...|
  Rat   197 QETRPRNYILSASASATLDDTSRSPPWAEWKEKHPGGWRLPCFFLLPLTPSVTLARGCLSLPEDR 261

  Fly   203 -------EQAERDLRVAQAEFDRQAEITKLLLDGISTSQASHLRHLHAFIQTQVRYYKQCGDVME 260
                   ::||::||.||.|||||||:|:|||:|||::..:|||.||.|:::|..||.||...|.
  Rat   262 KLWNDEVDKAEQELRAAQTEFDRQAEVTRLLLEGISSAHVNHLRCLHEFVKSQTTYYAQCYRHML 326

  Fly   261 QLQRELANLGG---PTPYIPLDVNEASASKSNISSGAAARGPGNNHSANMAATGHKPNQPMHVST 322
            .||::|.:..|   |..::......:....|...:..||..|.....|.:|     |.:...:..
  Rat   327 DLQKQLGSSQGAIFPGTFVGTTEPASPPLSSTSPTTTAATMPVVPTGAGLA-----PPEEAALCL 386

  Fly   323 DQM-------QRARVLCSYDAKDHTELNLSANEVIFVTECSPVNEDYMYGKQGLLKGLVPRAFVE 380
            :::       ::||||..|:|.|.:||.|.|:|:|.|.....::.|::.|::|..||.||..::|
  Rat   387 EEVAPPASGTRKARVLYDYEAADSSELALLADELITVYSLPGMDPDWLIGERGNKKGKVPVTYLE 451

  Fly   381 ML 382
            :|
  Rat   452 LL 453

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
EndoB	NP_611410.1	BAR_Endophilin_B	26..266	CDD:153278	124/310 (40%)
EndoB	NP_611410.1	SH3_Endophilin_B	327..378	CDD:212736	21/50 (42%)
Sh3glb2	XP_006233878.1	BAR	21..332	CDD:416402	124/310 (40%)
Sh3glb2	XP_006233878.1	SH3_Endophilin_B2	398..452	CDD:212877	21/53 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	247	1.000	Domainoid score	I2087
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	297	1.000	Inparanoid score	I2640
OMA	1	1.010	-	-		QHG49388
OrthoDB	1	1.010	-	-		D347900at33208
OrthoFinder	1	1.000	-	-		FOG0002653
OrthoInspector	1	1.000	-	-		otm44412
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR14167
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1759
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	11.080