DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment EndoB and SPBC19C2.10

DIOPT Version :9

Sequence 1:	NP_611410.1	Gene:	EndoB / 37218	FlyBaseID:	FBgn0034433	Length:	390	Species:	Drosophila melanogaster
Sequence 2:	NP_595695.1	Gene:	SPBC19C2.10 / 2540758	PomBaseID:	SPBC19C2.10	Length:	501	Species:	Schizosaccharomyces pombe

Alignment Length:	376	Identity:	81/376 - (21%)
Similarity:	148/376 - (39%)	Gaps:	82/376 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 SRVVQLTEEKLG-TTERTEYDLHFQNLAERADVTKTWTEKIVRDTESVLIPNPQNRVEDFIFEKI 85
            :::.|.|.||.| ..::|.....|.:|....|......:||.|.. :..:.|...| :..:.||
pombe     6 AKLSQWTGEKFGFDRQKTTLSDDFCSLKGETDAWLVGMDKIHRSC-TRWVRNMDKR-KGLLDEK- 67

  Fly    86 EKSKPKRLSNLEHLALDMIEAGGDFGQD-------LPYGQALIKVGQAEQKLGQCEHDFIATSGI 143
            :|..|     :.|:....:|.|......       :.||::::::|..:::.    .|::..|
pombe    68 DKQLP-----VTHVGSSFVELGQALSHSSSNSHTYIMYGKSMVEIGHLQEEF----MDYLNNS-- 121

  Fly   144 CFTQPLRKFLDGEMKTIGKERGILETKRLDLDACKNRVKKARSMLGQQSKDGISPEAVLEQAERD 208
             |...|...| .|.|.:..:...:|.:||..||...:::||:.   ::||           .|.|
pombe   122 -FLANLENSL-AEFKALDVKEKKMENRRLVFDALSTKIQKAKK---EESK-----------LEED 170

  Fly   209 LRVAQAEFDRQAEITKLLLDGISTSQASHLRHLHAFIQTQVRYYKQCGDVMEQLQ-------REL 266
            ||.|:|:::...|..:..:..:...:...:.::...:|.|:|::::..|:::.|:       |:.
pombe   171 LRNARAKYEESLEEFEDRMVQLKELEPDRVENVVRLLQMQIRFHQKSLDLLKGLEMNGFSKKRDN 235

  Fly   267 ANLGGPTPYIPLDVNEASASKSNISSGAAARGPGN-----------NHSANMAATGHKPNQPM-- 318
            .|       ||.....|.:..|||||...|..|.|           :.|:|   ..|.|...:
pombe   236 VN-------IPKRTYSARSIPSNISSTNVATTPSNTIFEMDDTLKADSSSN---EYHSPTNTLPS 290

  Fly   319 -HVSTDQMQRARVLCSYDAKDHTELN-----------LSANEVIFVTECSP 357
             |...|....:  :.|.:...|||.|           |..:.|...|..||
pombe   291 YHTEADLDNSS--IASSNRTQHTEDNYNKDVSDAQNSLGQSAVDLTTPSSP 339

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
EndoB	NP_611410.1	BAR_Endophilin_B	26..266	CDD:153278	53/254 (21%)
EndoB	NP_611410.1	SH3_Endophilin_B	327..378	CDD:212736	10/42 (24%)
SPBC19C2.10	NP_595695.1	BAR_MUG137_fungi	21..235	CDD:153277	48/243 (20%)
		CENP-T_N	<245..384	CDD:292789	25/100 (25%)
		SH3	430..482	CDD:302595
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR14167
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	3	2.970