DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment EndoB and Sh3rf3

DIOPT Version :9

Sequence 1:	NP_611410.1	Gene:	EndoB / 37218	FlyBaseID:	FBgn0034433	Length:	390	Species:	Drosophila melanogaster
Sequence 2:	NP_766376.2	Gene:	Sh3rf3 / 237353	MGIID:	2444637	Length:	878	Species:	Mus musculus

Alignment Length:	293	Identity:	55/293 - (18%)
Similarity:	96/293 - (32%)	Gaps:	104/293 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   154 DGEMKTIGKERGILETKRLDLDACKNRVKKARSMLGQQSKDGISPEAVLEQAERDLRV--AQAEF 216
            :||.:...::||.......|:|        ..|:|     |.:.....||:.:...:|  .|..|
Mouse    21 EGEDRQGEQQRGAQARTEEDMD--------ESSLL-----DLLECSVCLERLDTTAKVLPCQHTF 72

  Fly   217 DRQAEITKLLLDGISTSQASHLRHLHAFIQTQVRYYKQCG--------------DVMEQLQRELA 267
            .|:.      |:.|..|:       |.....:.|....||              |.:.|..|..|
Mouse    73 CRRC------LESIVCSR-------HELRCPECRILVGCGVDELPANILLVRLLDGIRQRPRTGA 124

  Fly   268 NLGGPTPYIPLDVNEASASKSNISSGAAARGPGNNHSANMAATGHKPNQPMHVST---------- 322
            :.|...|..|     ...:.|.::.||.            .|||..|..|:.:|.
Mouse   125 SPGSSPPARP-----GPGTFSALAGGAG------------GATGSPPCSPVFLSAAAGSSTSSLC 172

  Fly   323 --------------DQMQRARVLCSYDAKDHTELNLSANEVIFVTECSPVNEDYMYGKQGLLKGL 373
                          .|:..|:.|.||:.|:..:|..:..::|.:..  .|:|::.:|:...:.|.
Mouse   173 DVATNRSVPVAKTLSQLPYAKALYSYEGKEPGDLKFNKGDIIILRR--KVDENWYHGELQGMHGF 235

  Fly   374 VPRAFV-------------------EMLDEEHD 387
            :|.:::                   ||.|.:.|
Mouse   236 LPASYIQCVRPLPQALPQGKALYDFEMKDRDQD 268

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
EndoB	NP_611410.1	BAR_Endophilin_B	26..266	CDD:153278	25/127 (20%)
EndoB	NP_611410.1	SH3_Endophilin_B	327..378	CDD:212736	12/50 (24%)
Sh3rf3	NP_766376.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	19..40		4/18 (22%)
		RING	51..93	CDD:238093	10/54 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	120..145		6/29 (21%)
		SH3	190..243	CDD:302595	12/54 (22%)
		SH3	253..307	CDD:302595	4/16 (25%)
		Interaction with RAC1. /evidence=ECO:0000250\|UniProtKB:Q8TEJ3	364..433
		SH3_SH3RF3_3	461..517	CDD:212858
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	574..659
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	688..758
		SH3_SH3RF_C	823..877	CDD:212719
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167839805
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930