DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment EndoB and Sorbs3

DIOPT Version :9

Sequence 1:	NP_611410.1	Gene:	EndoB / 37218	FlyBaseID:	FBgn0034433	Length:	390	Species:	Drosophila melanogaster
Sequence 2:	NP_035496.1	Gene:	Sorbs3 / 20410	MGIID:	700013	Length:	733	Species:	Mus musculus

Alignment Length:	187	Identity:	39/187 - (20%)
Similarity:	77/187 - (41%)	Gaps:	23/187 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   206 ERDLRVAQAEFDRQAEITKLLLDGISTSQASHLRHLHAFIQTQVRYYKQCGDVMEQLQRELANLG 270
            ||:|....||.|:.....:..|.....|||..            |..:|.| :.:|....|::..
Mouse   334 ERELAKLSAELDKDLRAIETRLPSPKNSQAPR------------RPLEQPG-LEQQPSARLSSAW 385

  Fly   271 GP-TPYIPLDVNEASASKSNISSGAAARGPGNN-----HSANMAATGHKPNQPMHVSTDQMQRAR 329
            .| :|:.|...:....|...::.|..:...|..     .||...:...:.:.|......:.:.||
Mouse   386 RPNSPHAPYFSSSRPLSPHRMADGGGSPFLGRRDFVYPSSAREPSASERGSSPSRKEEKKRKAAR 450

  Fly   330 VLCSYDAKDHTELNLSANEVIFVTECSPVNEDYMYGKQGLLKGLVPRAFVEML--DE 384
            :...:.|:...||:|...:::::.:  .|:::::.|:.....|:.|..:||:|  ||
Mouse   451 LKFDFQAQSPKELSLQKGDIVYIHK--EVDKNWLEGEHHGRLGIFPANYVEVLPADE 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
EndoB	NP_611410.1	BAR_Endophilin_B	26..266	CDD:153278	14/59 (24%)
EndoB	NP_611410.1	SH3_Endophilin_B	327..378	CDD:212736	10/50 (20%)
Sorbs3	NP_035496.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..51
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	129..165
		Sorb	165..214	CDD:128735
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	224..285
		PTZ00449	<306..>445	CDD:185628	24/123 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	352..448		18/108 (17%)
		Binds to vinculin	444..579		15/64 (23%)
		SH3_Vinexin_1	447..501	CDD:212854	12/55 (22%)
		SH3_Vinexin_2	521..576	CDD:212857
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	584..672
		Binds to SOS. /evidence=ECO:0000250	674..733
		SH3_Vinexin_3	676..733	CDD:212851
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167839806
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840