DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7461 and acoxl

DIOPT Version :9

Sequence 1:	NP_001286611.1	Gene:	CG7461 / 37217	FlyBaseID:	FBgn0034432	Length:	627	Species:	Drosophila melanogaster
Sequence 2:	XP_697559.4	Gene:	acoxl / 569104	ZFINID:	ZDB-GENE-081107-18	Length:	652	Species:	Danio rerio

Alignment Length:	575	Identity:	125/575 - (21%)
Similarity:	224/575 - (38%)	Gaps:	116/575 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    75 TNSLIDPFERFFSDVNDAARNDANSKID---------------DTTSTALWELGAFGIQVP--SE 122
            ::||....:..|.::.||.| ||.||.|               |.|:..|:.:    ::.|  .|
Zfish    11 SSSLARYLDGEFWEIKDAFR-DAISKSDLFQSSCYERTLDQNRDLTADRLYHI----LRQPVMKE 70

  Fly   123 FGGLGLNNTQYG------RLCAIVGVNDLGLGITIGAHQSIGFKGILLYGTPEQKEKYLPKVAAE 181
            .....|...|.|      .:..:|...|:..|:.:|....:....:...|:||||.|:...|:..
Zfish    71 HLKNQLKEKQKGFINKSMSITEVVCAADMNTGVKLGVVCGLYGGAVNNLGSPEQKIKFYLPVSEL 135

  Fly   182 QVYAAFALTEPSSGSDAGSIRCRAVKSADGKHYVL-----NGSKIWISNGGIAEIMTVFAQT--- 238
            |....||:||...||:...|...|......:.:::     :..|::|.|........||||.
Zfish   136 QFTGMFAMTERGHGSNVRGIITEARYDQPTQEFIIHTPSEDAHKMYIGNAMKGNFAAVFAQLIIN 200

  Fly   239 -EQVDPKTGEKKDKVTAFIV----ERS--FGGVTNGPPEKKMGIKASNTAEVYFEDVKIPIENVL 296
             |...|.         .|:|    |..  :.|||....:.|.|:...:...:.|::|:||.||:|
Zfish   201 GESQGPH---------CFVVPIRDENGVMWPGVTVSDMKHKEGLHGVDNGILIFDNVRIPRENLL 256

  Fly   297 GKEG----DG-----------FKVAMNILNNGRFGMGATLSGTMKKCIEQATEHANNRVQFGQKL 346
            ||.|    ||           |...:..|...|.|:.......||..:..|..::::|.|||.|.
Zfish   257 GKFGSVSADGLYSSPALRGNRFNAMLAALTPTRLGLTVQAMAAMKLGLIIAVCYSHSRRQFGPKD 321

  Fly   347 KNYGSIQEKLAQ-MNILQYATESMAFTISQNMDAG--------SKDYHLEAAISKIYA---SESA 399
            :....|.|...| :.::.:.:.::|.|.:....|.        .:|.....|:..:.|   :.|.
Zfish   322 QEEVKIMEHQTQNLRLMPHLSAALALTFTSRYAADLMDDALCKGEDLQSNRALQALVAGLKAYST 386

  Fly   400 W--YVC-DEAIQILGGMGYMVDNGLERVLRDLRIFRIFEGTNDILRLFIALTGIQYAGSHLKELQ 461
            |  ..| .:..:..||||:|::|.:..:..|..:|..|||.|.::...:           ::||.
Zfish   387 WANVACLQDCRECTGGMGFMMENRIPSLKCDSDVFVTFEGDNMVMLQVV-----------VRELL 440

  Fly   462 RAFKNPSAN---LGLIFKEASRRAASTVGLGGTDLSGHVVGELLPYAKKTAHCIDLFGQSV---- 519
            ..:.....|   :||| :..:..|:.::.......|...||:|:...|...:...:..:|:
Zfish   441 TQYTKQMGNNLVMGLI-RNLTSSASDSLRTSFLGFSVDKVGDLMFLLKAVRYRERVLQRSLASRL 504

  Fly   520 --------EELLLRYNK---NIVNEQILLTRLANAAIDIYAMVV--TQSRSSRAV 561
                    ||..:.:|.   :::.  :.:..:....::.:|:.|  .|.:..||:
Zfish   505 YTKVDKNKEEFFMAWNSCLHHVIT--LAMAHIHRVTLEQFALAVQDCQIKEDRAL 557

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7461	NP_001286611.1	VLCAD	45..454	CDD:173850	104/446 (23%)
CG7461	NP_001286611.1	CaiA	67..446	CDD:224871	104/438 (24%)
acoxl	XP_697559.4	PLN02636	8..637	CDD:215342	125/575 (22%)
acoxl	XP_697559.4	ACAD	44..625	CDD:299127	114/541 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1960
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810