DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7461 and Acox1

DIOPT Version :9

Sequence 1:	NP_001286611.1	Gene:	CG7461 / 37217	FlyBaseID:	FBgn0034432	Length:	627	Species:	Drosophila melanogaster
Sequence 2:	NP_059036.1	Gene:	Acox1 / 50681	RGDID:	619757	Length:	661	Species:	Rattus norvegicus

Alignment Length:	541	Identity:	117/541 - (21%)
Similarity:	196/541 - (36%)	Gaps:	121/541 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 KEKASE--NESFMANIFRGSLVSSQVFPYPDVLTAEQKELTNSLIDPFERFFSDVNDAARNDANS 99
            ||:||.  |...:.:|..||         |: .|..::|:.|.:::..:....|.|...|:....
  Rat     7 KERASATFNPELITHILDGS---------PE-NTRRRREIENLILNDPDFQHEDYNFLTRSQRYE 61

  Fly   100 KIDDTTSTALWELGAFGIQVPSE---FGGLGLNNTQYGRLCAIVGVNDLGLGITIGAHQSIGFKG 161
            .....::|.:.::..:||..|.|   |..|.|.|.          |..:||      :.|:....
  Rat    62 VAVKKSATMVKKMREYGISDPEEIMWFKKLYLANF----------VEPVGL------NYSMFIPT 110

  Fly   162 ILLYGTPEQKEKYLPKVAAEQVYAAFALTEPSSGSDAGSIRCRAVKSADGKHYVLNGS-----KI 221
            :|..||..|:||::......|:...:|.||...|:....:...|......:.::||..     |.
  Rat   111 LLNQGTTAQQEKWMRPSQELQIIGTYAQTEMGHGTHLRGLETTATYDPKTQEFILNSPTVTSIKW 175

  Fly   222 WISNGGIAEIMT---VFAQTEQVDPKTGEKKDKVTAFIVE-RSFG------GVTNGPPEKKMGIK 276
            |  .||:.:...   |.||........|     :.||:|. |..|      |:|.|....|.|.:
  Rat   176 W--PGGLGKTSNHAIVLAQLITQGECYG-----LHAFVVPIREIGTHKPLPGITVGDIGPKFGYE 233

  Fly   277 ASNTAEVYFEDVKIPIENVLGK------EGDGFKVAMNILNNG------RFGMGATLSGTMKKC- 328
            ..:...:..::.:||.||:|.|      :|...|...|.|..|      .|.:|.......|.|
  Rat   234 EMDNGYLKMDNYRIPRENMLMKYAQVKPDGTYVKPLSNKLTYGTMVFVRSFLVGNAAQSLSKACT 298

  Fly   329 --IEQATEHANNRVQFGQ---KLKNYGSIQEKLAQMNILQYA-------TESMAFTISQNMDAGS 381
              |..:.....:.::..:   ::.::.:.|.||..:....||       .:.....|::::..|.
  Rat   299 IAIRYSAVRRQSEIKQSEPEPQILDFQTQQYKLFPLLATAYAFHFVGRYMKETYLRINESIGQGD 363

  Fly   382 ----KDYHLEAAISKIYASESAWYVCDEAIQILGGMGYMVDNGLERVLRDLRIFRIFEGTNDILR 442
                .:.|...|..|.:.:.:|....:|.....||.||...:|:..:.........|||.|.::.
  Rat   364 LSELPELHALTAGLKAFTTWTANAGIEECRMACGGHGYSHSSGIPNIYVTFTPACTFEGENTVMM 428

  Fly   443 LFIA----------LTGIQYAG--SHLKELQRAFKNPSANL------------------GLIFKE 477
            |..|          .:|....|  |:|.:|      ||..:                  ||  .|
  Rat   429 LQTARFLMKIYDQVRSGKLVGGMVSYLNDL------PSQRIQPQQVAVWPTMVDINSLEGL--TE 485

  Fly   478 ASR-RAASTVGLGGTDLSGHV 497
            |.: |||..|.:...:|..||
  Rat   486 AYKLRAARLVEIAAKNLQTHV 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7461	NP_001286611.1	VLCAD	45..454	CDD:173850	95/465 (20%)
CG7461	NP_001286611.1	CaiA	67..446	CDD:224871	89/425 (21%)
Acox1	NP_059036.1	AXO	3..638	CDD:173839	117/541 (22%)
Acox1	NP_059036.1	Microbody targeting signal	659..661
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1960
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810