DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7461 and Egm

DIOPT Version :9

Sequence 1:	NP_001286611.1	Gene:	CG7461 / 37217	FlyBaseID:	FBgn0034432	Length:	627	Species:	Drosophila melanogaster
Sequence 2:	NP_610687.1	Gene:	Egm / 36242	FlyBaseID:	FBgn0086712	Length:	639	Species:	Drosophila melanogaster

Alignment Length:	603	Identity:	153/603 - (25%)
Similarity:	270/603 - (44%)	Gaps:	46/603 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 ESNRSKEKASENESFMANIFRGSLVSSQVFPYPDVLTA-EQKELTNSLIDPFERFFSDVNDAARN 95
            ||...:.|....|....|.|.| :|..::..||:|:.. |..:|.|||: |.:.:|.:..:.
  Fly    55 ESPEQQRKLPTREPLAKNFFIG-VVDKELLAYPEVIPRDEMAQLENSLL-PLKNYFVEPRET--- 114

  Fly    96 DANSKIDDTTSTALWELGAFGIQVPSEFGGLGLNNTQYGRLCAIVG--VNDLGLGITIG--AHQS 156
                  ::|:...|.:||.:|:.|.:::.|.|     ||...:::.  .:...:.:|:|  .|:.
  Fly   115 ------EETSPETLRQLGLYGLNVSTDYEGKG-----YGWSASLMASEPDSTDINVTLGLQTHRV 168

  Fly   157 IG--FKGILLYGTPEQKEKYLPKVAAEQVYAAFALTEPSSGSDAGSIRCRAVKSADGKHYVLNGS 219
            :.  .|.:   |||.|:::||..:|..::....|:.|.|...:........:....|| :.|||.
  Fly   169 VVDLLKEV---GTPLQQQRYLQDLATGKLIGTEAIYEISPPEEDYFNTTAELFPEYGK-WQLNGE 229

  Fly   220 KIW-ISNGGIAEIMTVFAQTEQVDPKT-GEKKDKVTAFIVERSFGGVTNGPPEKKMGIKASNTAE 282
            |.: |...|..::..|.|||:|  |.. |......|.|:|:....||..|......|.:.:....
  Fly   230 KSFVICTPGERQLFLVLAQTQQ--PNVPGVLGRGTTIFLVDSQQEGVRLGEKHATFGCRKAEIRR 292

  Fly   283 VYFEDVKIPIENVLGKEGDGFKVAMNILNNGRFG---MGATLSGTMKKCIEQATEHANNRVQFGQ 344
            |:||.||:..:.|:|...||.:.:..::.:.|..   :|.:|:   ||.:.:..::..|..|.|.
  Fly   293 VHFEGVKLGEDQVVGLPHDGNRYSEQLVRSSRLRGSLVGLSLA---KKLLNELAQYTVNTTQCGV 354

  Fly   345 KLKNYGSIQEKLAQMNILQYATESMAFTISQNMDA-GSKDYHLEAAISKIYASESAWYVCDEAIQ 408
            :|::....:..:::.....||.|||.:..:..:|. .::|..||:||:|.:.....:.:..:.:.
  Fly   355 QLQDLELTRIHMSRAMCSVYAMESMLYLTAGLLDEFRAQDVTLESAITKYFTLRQVYAIASQNLG 419

  Fly   409 ILGGMGYMVDNGLERVLRDLRIFRIFEGTNDILRLFIALTGIQYAGSHLKELQRAFKNPSANLGL 473
            ::|....:.....|..|||.........:.|.|.:||||||:|:||..:....|..:||..|.|.
  Fly   420 VVGPKSLLSGETTELGLRDAAQLCTQGESLDTLGMFIALTGLQHAGQAMNTGVRKSRNPLFNPGH 484

  Fly   474 IFKEASRRAASTVGLGGTDLSGHVVGELLPYAKKTAHCIDL----FGQSVEELLLRYNKNIVNEQ 534
            ||.:.....:.........||.||    .|..:..|.||:|    ...:||.:..::...:|..|
  Fly   485 IFGKFLDNNSIDNPKTKMQLSEHV----HPSLEAAAQCIELSVARLQMAVELMFTKHGNAVVERQ 545

  Fly   535 ILLTRLANAAIDIYAMVVTQSRSSRAVNLNLPTAQHELNMTKALTIQASDRVIKNLQAATSSHHR 599
            ..:.|||.....||||..:.:|:||:..:.||.|.|||....|:..:..|||..........|..
  Fly   546 SEMQRLAEVGTLIYAMWASVARASRSYCIGLPLADHELLTATAICSEGRDRVRTLCTEIYGGHFV 610

  Fly   600 SLNEKISTIAKTTLENGG 617
            :.:..:..::|...::.|
  Fly   611 NNDNNLVRLSKQVAKSKG 628

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7461	NP_001286611.1	VLCAD	45..454	CDD:173850	104/421 (25%)
CG7461	NP_001286611.1	CaiA	67..446	CDD:224871	91/391 (23%)
Egm	NP_610687.1	ACAD	92..457	CDD:173838	91/388 (23%)
Egm	NP_610687.1	CaiA	122..439	CDD:224871	79/330 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1960
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D163462at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.820