Protein Alignment Acadvl and Gcdh

DIOPT Version :10

• Sequence 1: NP_611409.2
• Gene: Acadvl / 37217
• FlyBaseID: FBgn0034432
• Length: 627
• Species: Drosophila melanogaster
• Sequence 2: NP_032123.3
• Gene: Gcdh / 270076
• MGIID: 104541
• Length: 447
• Species: Mus musculus
• Alignment Length: 1086
• Identity: 207/1086 - (19%)
• Similarity: 337/1086 - (31%)
• Gaps: 335/1086 - (30%)

  Fly   360 RHHKVPG--------GMKRRVLRWYDYSWSRGRIQGGGDINTALGLLPDKLKTELALHVNLSVLK 416
            |.|...|        |.|.:||...:..:..|.::|      ..|..|.....|:|       |:
Mouse   615 RSHSAQGDREISFNKGDKVKVLSVGEGGYWEGTVRG------RTGWFPSDCVEEVA-------LR 666

  Fly   417 KVTIFQECQPE-----FLH-------------DLVLKMKAYIFTPGDS-----ICR--KGEVARE 456
            .:....|.:.|     |.|             |.::|.|..:....|:     :.|  |.:...|
Mouse   667 SLESRSESRSERAKRLFRHYTVGSYDSFDAPSDYIIKEKTVLLQKKDNEGFGFVLRGAKAQTPIE 731

  Fly   457 MFIIADGI-----LEVLSETGKVLTT-MKAGDFFGEIGILNLDGLNKRTADVRSVGYSELFSLSR 515
            .|......     ||.:.|.|..... ::.|||     ::.::|.|     |..||:.::.::.|
Mouse   732 EFTPTPAFPALQYLESVDEGGVAWRAGLRMGDF-----LIEVNGQN-----VVKVGHRQVVNMIR 786

  Fly   516 ED---------VLTAMKDYPEA--QEILQTLGRKRLMEVRCVNKKHANKHAAKEHAGDRSSN--T 567
            :.         ::|...|..|.  ::|.|   :.:.:....:..:..:..:..|...||:|.  .
Mouse   787 QGGNSLMVKVVMVTRNPDMEEGVRKKIPQ---QSKRLSTPAIALRSKSMTSELEEMVDRASAPWK 848

  Fly   568 HNNQGDSSDNSASKRIV-----DKLRSDVKGLKNVLRKSRT------GTTRRSNESIEMQPLHGN 621
            ..::.:||..:..||.|     :||...:...:..:..:..      |..|........:|....
Mouse   849 KKSEFESSQATEKKRTVYQMALNKLDEILAAAQQTINTNEAPGPRVQGVKRERGRGFYNEPNFDQ 913

  Fly   622 ATSGGGSGGAGSGGSAG---SGGSKTSKTMLKRMPRVKSDDIHTEDEGKDNDKVPSPIGAGLPLL 683
            ...|..|.|||.|...|   ||                    |....|....|     ..|:|
Mouse   914 TGMGMTSSGAGLGYDRGQFVSG--------------------HGPPHGMLRQK-----SIGVP-- 951

  Fly   684 QRLRLLKEKQDREERAAKATAQIISPPHTHVTSAIS-------PQESIQEEPEPEVIGAGLPLMQ 741
                       .||:      |.:.||......::|       |.......|||....|. ||..
Mouse   952 -----------EEEK------QFLHPPAMKFARSLSVPGPDEIPPPPTTAPPEPPFSSAP-PLGF 998

  Fly   742 RLKLLKAKEDRLAKESQSKVIPILNTTGVAGHHAKPTMRVSFKERLRQLHHQDSKH--HGESKPS 804
            |           .|.||...:.:..:|..|.|:              ||:.| |.|  ||....|
Mouse   999 R-----------GKTSQQPSVSMSQSTSSAAHY--------------QLYSQ-SVHVTHGPRDRS 1037

  Fly   805 SVPVTIHETTDMKQHLLPIVPSPGSKAQPIQQQHHQQQSHHPSKPSTAQSLKDKIRSLGHL---- 865
            ..|.|                  ||....:...|.|.   |||.||...|.| .|...|.|
Mouse  1038 PGPPT------------------GSGTGDLAYSHAQA---HPSVPSRTASRK-VIGYTGDLAGAG 1080

  Fly   866 -----KADDQLKPWSK----LKLATVV-------------------SLGGSYTSLNNAASEESPI 902
                 ||....:.:|.    ..:|||:                   .:|........|...:.|:
Mouse  1081 GVAGAKAAALRRGYSNAVPPTSVATVIPQQQQTTQNQPSRMDRSGMGVGAGGVPKGGARRGKGPL 1145

  Fly   903 LKQSKRSRL--------------KTSIPADLNL---------------NSLVSMTPPPISS---- 934
            :||||...|              |:|||....:               :|:.:..|||..|
Mouse  1146 VKQSKVEDLRQGQDTLEAKVSVEKSSIPIPTIIVKAPSTSSSGRSSQGSSVEAEPPPPGESDSSK 1210

  Fly   935 ---------------APPTTCAPPSSFLPN---------------KILSCAAGEAASVSDSEVAS 969
                           |||:..|||...||:               .|:..|..:.....::...|
Mouse  1211 PEPVVPPPAPTVPPPAPPSIPAPPPPSLPSLRTQESLDFTSQFGAAIVGAARRDRERFHEARRKS 1275

  Fly   970 GSRTQRTTGDQGGARAVPARVRMKPKPIKLESTEPKSYL----SIDDLSPEYCGLPFVKKLKILN 1030
            .|.......:..||.....|.:...:.:   |::|...|    |||:  ..:.|..|:...:.:.
Mouse  1276 ASFFLSAEEELSGAGGAGGRTQTSQQQL---SSQPSPRLRPSKSIDE--GMFSGDTFIHHTRSMP 1335

  Fly  1031 ERQKLAELESA-----IKTRSLSLDCTDSNTSTASTHDLLDQLTRSQSEGSGMAHTVRSKSESPK 1090
            ....|.|..|.     .:.:|:..|...:.:...      .|..:.|:..:...|.:..|...|
Mouse  1336 PAFGLPEYSSPAPQGDYQPKSVPADFYGAGSRQQ------QQQQQQQAPTTTFIHPLTGKVLDP- 1393

  Fly  1091 RSDSNGLLPLSPESNETLERRQLKSILKKLSEDKAALEQRPNRENLKKLMRAQTVEGYVARHSKF 1155
             |...||         .|..|:     :.|.:|.....:|....:..:  :..::..:.:..|:.
Mouse  1394 -SSPLGL---------ALAARE-----RALKDDGRIRRERTTEHHFTR--QLSSIGAFSSSTSQP 1441

  Fly  1156 TKSVTFHRNTLSSPPSSAAQCDPIEERSLFPLLSAQTATGIVPGVPHSVAAAPLATSH---VDER 1217
            |..:::...:.||..|||||........:.....|.|.|...|..|..:..|..:.|.   |.||
Mouse  1442 TSHISYPMASSSSATSSAAQSTNTSSYLVTSSSLAATTTSTRPPSPRILRGAGSSWSEEAGVGER 1506

  Fly  1218 L---SAVATASIEQEHERYYQ--VLHEEHHHHEEHHHRAEHRQFHR 1258
            .   :|..:|..|....|:.:  .:|..|:..:::....:.|:..|
Mouse  1507 ADREAAGTSAPREGLRVRFSEDKTVHTHHYQSQQYQPTFKERERER 1552

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Acadvl	NP_611409.2	VLCAD	45..454	CDD:173850	24/126 (19%)
Gcdh	NP_032123.3	GCD	57..443	CDD:173840