DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tab2 and Tab3

DIOPT Version :9

Sequence 1:	NP_001246417.1	Gene:	Tab2 / 37216	FlyBaseID:	FBgn0086358	Length:	831	Species:	Drosophila melanogaster
Sequence 2:	NP_001345376.1	Gene:	Tab3 / 66724	MGIID:	1913974	Length:	716	Species:	Mus musculus

Alignment Length:	862	Identity:	190/862 - (22%)
Similarity:	277/862 - (32%)	Gaps:	313/862 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 PGSNTHQLNGKTVGKGNPLAEAINQHFQRKK-----QNQHQSP---NPSPNPNP--NSPASRSGS 63
            ||...|...|:|:...:.......||...|:     |..|.:|   ..:||.||  .:..:||.
Mouse    86 PGDGAHLNGGRTLVHSSSDGHIDPQHTAGKQLICLVQEPHSAPAVVAATPNYNPFFMNEQNRSA- 149

  Fly    64 YEQLELLDHATHPQQ--QQEAS-------SGKAKPSCHCTNISIMHLFHEMKQEFPTIPDAIVTQ 119
                     ||.|.|  ||.:|       |....||......|.||:     ..:.|.|   :|.
Mouse   150 ---------ATPPSQPPQQPSSMQTGMNPSAMQGPSPPPPPPSYMHI-----PRYSTNP---ITV 197

  Fly   120 CVNENCHQRENCIQMLRKELALHPIPVQSY--PAKVLQQQQQQHHQNRQAKPPTPLKPSRIAPPQ 182
            .|::|....:...:.|:   .|..||...|  |..:..:|..|....||.....|.:.|    ||
Mouse   198 TVSQNLPSGQTVPRALQ---ILPQIPSNLYGSPGSIFIRQTSQSSSGRQTPQNAPWQSS----PQ 255

  Fly   183 PEAVLSNGVATPPGVGSPHPDTQPRPRPTTLNLQRQFSTQLQQKIMQRQQRQQRDHQPA------ 241
                            .|.|....||.|...:.|....:|...|  |:|..|...|.|.
Mouse   256 ----------------GPVPHYSQRPLPVYPHQQNYQPSQYSPK--QQQIPQSVYHSPPPSQCPS 302

  Fly   242 -------QLTPTSLSKPLRRA--PPLP-----------PPPKPKPGSFSNDSSCLTSPMSSSESE 286
                   |:.|..|..|....  ||.|           ||...||||.|......|   :||..:
Mouse   303 PFSSPQHQVQPPQLGHPSSHVFMPPSPSTTPPHLYQQGPPSYQKPGSHSVAYLPYT---ASSLPK 364

  Fly   287 LSLNAVPLS-SPTSAAATAAAASAAIASTQQQPSPVRHRSVITLQPEPPYARDFRSIDFPPTTAC 350
            .|:..:.:: .|:....||...|         |||:.:      ||.|   |:..|:    .||.
Mouse   365 GSMKKIEITVEPSQRPGTAITRS---------PSPISN------QPSP---RNQHSL----YTAT 407

  Fly   351 TPRLPSPSSAASPSAPGGRKSFTSLNLTLRQPTGSAQSAIDITAGPAPSGQGSGITYSSVSFDAR 415
            ||...|||...| |.|....|...:.:|..||||.       :..|:||.:......:.......
Mouse   408 TPPSSSPSRGIS-SQPKPPFSVNPVYITYTQPTGP-------SCAPSPSPRVIPNPTTVFKITVG 464

  Fly   416 RGTQKNFQLTVTDEGSVFSAGSVRPRTLYATPCEPVTSVPANQQPPPPAAVVADGLGDADMTSDV 480
            |.|.:|. |.:.|:         ..|:....|.:|::.:|              |.|.
Mouse   465 RATTENL-LNLVDQ---------EERSAAPEPIQPISVIP--------------GSGG------- 498

  Fly   481 FPYPTQEQNHIVASNYSNNHAVSDNNNIGISNSTDSSPTMPLYEGVMEECDREARAATIERQKQR 545
                 ::.||    .|..:.:         |.|.|.:.|.                |.:..|:.|
Mouse   499 -----EKGNH----KYQRSSS---------SGSDDYAYTQ----------------ALLLHQRAR 529

  Fly   546 RDKLANALRDNKKRLLVLEQEINIL--------------TEPVPVGES-ERL---DRDIKQLTED 592
            .::||..|:..|:.|..|:.|:|.:              |..:|..|. .||   :|.: |:..|
Mouse   530 MERLAKQLKLEKEELERLKAEVNSMEHDLMQRRLRRVSCTTAIPTPEEMTRLRSTNRQL-QINVD 593

  Fly   593 CN-RLLDCLNEPQANGP-GPAANPTNRQHLLPASNASQQQPQQQPQPFPR--------QRQSARV 647
            |. :.:|.|   |:.|. .|.|......|:.|.       |...|:|..:        :|::.|:
Mouse   594 CTLKEVDLL---QSRGNFDPKAINNFYDHIEPG-------PVVPPKPSKKDSSDSCAIERKARRI 648

  Fly   648 ----QAPPSSLRLHSVPAAPISQPVQDFGQHHSSAPTSACLTPQMQSQQQLLQLQQEPPPTYAQY 708
                :||   :.:|...||...:.:            |.|
Mouse   649 SVTSKAP---VDIHDAQAAAADEHL------------SIC------------------------- 673

  Fly   709 YQFQQYLQQQRQQQLQQQMQQQQQLQHQMQQQQQPQPQQEEEFLSDSDVDEEEETLDSWACNMCT 773
                                         :|..:.||:           ||:.|.. .|.|:.||
Mouse   674 -----------------------------KQSARTQPR-----------DEDYEGA-PWNCDSCT 697

  Fly   774 FRNHPQLNICEACENVR 790
            |.|||.||.||.||..|
Mouse   698 FLNHPALNRCEQCEMPR 714

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tab2	NP_001246417.1	CUE_TAB2_TAB3	98..138	CDD:270545	8/39 (21%)
		NYD-SP28	528..>602	CDD:291438	22/92 (24%)
		ZnF_RBZ	765..789	CDD:197784	14/23 (61%)
		RanBP2-type Zn finger	767..786	CDD:275376	12/18 (67%)
Tab3	NP_001345376.1	CUE_TAB2_TAB3	9..50	CDD:270545
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	141..189		15/62 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	227..349		33/143 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	373..433		23/82 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	479..513		10/72 (14%)
		ZnF_RBZ	691..713	CDD:197784	14/21 (67%)
		RanBP2-type Zn finger	691..710	CDD:275376	12/18 (67%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	82	1.000	Domainoid score	I8423
eggNOG	1	0.900	-	-		E1_28IZ6
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	89	1.000	Inparanoid score	I5110
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.950