DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tab2 and TAB3

DIOPT Version :9

Sequence 1:	NP_001246417.1	Gene:	Tab2 / 37216	FlyBaseID:	FBgn0086358	Length:	831	Species:	Drosophila melanogaster
Sequence 2:	XP_016884888.1	Gene:	TAB3 / 257397	HGNCID:	30681	Length:	721	Species:	Homo sapiens

Alignment Length:	730	Identity:	154/730 - (21%)
Similarity:	243/730 - (33%)	Gaps:	248/730 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    99 MHLFHEMKQEFPTIPDAIVTQCVNENCHQRENCIQMLRKE------------------------- 138
            :.:.|:::|.||.||:.:|:||:.:|.:..|.|.:.|.:|
Human    10 IQVLHDLRQRFPEIPEGVVSQCMLQNNNNLEACCRALSQESSKYLYMEYHSPDDNRMNRNRLLHI 74

  Fly   139 -LALHPIPVQSYPAKVLQQQ----------------------------QQQH------------- 161
             |.:|. |...:|....|..                            |:.|
Human    75 NLGIHS-PSSYHPGDGAQLNGGRTLVHSSSDGHIDPQHAAGKQLICLVQEPHSAPAVVAATPNYN 138

  Fly   162 -----HQNRQAKPPTPLKPSRIAPPQPEAVLSNGVATPPGVGSPHPDTQPRPRPTTLNLQRQFST 221
                 .|||.|..|    ||:  |||..:.:..|: .|..:..|.|   |.|.|:.:::.|..:.
Human   139 PFFMNEQNRSAATP----PSQ--PPQQPSSMQTGM-NPSAMQGPSP---PPPPPSYMHIPRYSTN 193

  Fly   222 QLQQKIMQRQQRQQRDHQPAQLTPTSLSKPLRRAPPLPPPPKPKPGSFSNDSSCLTSPMSSSESE 286
            .:...:.|.....|           ::.:.|:..|.:|......|||.....   ||..||...
Human   194 PITVTVSQNLPSGQ-----------TVPRALQILPQIPSNLYGSPGSIYIRQ---TSQSSSGRQ- 243

  Fly   287 LSLNAVPLSSPTSAAATAAAASAAIASTQQQP-SPVRHRSVITLQPEPPYARDFRSIDFPPTTAC 350
                 .|.|:|                .|..| .||.|.|...| |..|:.::::...:.|....
Human   244 -----TPQSTP----------------WQSSPQGPVPHYSQRPL-PVYPHQQNYQPSQYSPKQQQ 286

  Fly   351 TPR----LPSPSSAASP-SAPGGRKSFTSLNLTLRQPTGSAQSAIDITAGPAPSGQGSG------ 404
            .|:    .|.||...|| |:|..:...:.|......|:.|.........|| ||.|..|
Human   287 IPQSAYHSPPPSQCPSPFSSPQHQVQPSQLGHIFMPPSPSTTPPHPYQQGP-PSYQKQGSHSVAY 350

  Fly   405 --ITYSSVSFDARRGTQKNFQLTVTDE---GSVFS------AGSVRPR---TLYATPCEPVTSVP 455
              .|.||:|    :|:.|..::||...   |:..:      :....||   :|| |...|.:|.|
Human   351 LPYTASSLS----KGSMKKIEITVEPSQRPGTAINRSPSPISNQPSPRNQHSLY-TATTPPSSSP 410

  Fly   456 A---NQQPPPPAAV------VADGLGDADMTSDVFPYPTQEQNHIVASNYSNNHAVSDNNNIGIS 511
            :   :.||.||.:|      .....|.:...|   |.|....|.......:...|.::|    :.
Human   411 SRGISSQPKPPFSVNPVYITYTQPTGPSCTPS---PSPRVIPNPTTVFKITVGRATTEN----LL 468

  Fly   512 NSTDS-------SPTMPLY-------EGVMEECDREARA---------ATIERQKQRRDKLANAL 553
            |..|.       .|..|:.       |....:..|.:.:         |.:..|:.|.::||..|
Human   469 NLVDQEERSAAPEPIQPISVIPGSGGEKGSHKYQRSSSSGSDDYAYTQALLLHQRARMERLAKQL 533

  Fly   554 RDNKKRLLVLEQEINIL--------------TEPVPVGES----ERLDRDIKQLTEDCN-RLLDC 599
            :..|:.|..|:.|:|.:              |..:|..|.    ..::|.: |:..||. :.:|.
Human   534 KLEKEELERLKSEVNGMEHDLMQRRLRRVSCTTAIPTPEEMTRLRSMNRQL-QINVDCTLKEVDL 597

  Fly   600 LN-----EPQANG-------PGPAANPTNRQHLLPASNASQQQPQQ----------QPQPFPRQR 642
            |.     :|:|..       |||...|.      |:...|:...|.          ||:| ||.:
Human   598 LQSRGNFDPKAMNNFYDNIEPGPVVPPK------PSKKGSRSVAQAGVQWHDHSSLQPRP-PRLK 655

  Fly   643 QSARVQAPPSSLRLH 657
                    |||...|
Human   656 --------PSSCLSH 662

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tab2	NP_001246417.1	CUE_TAB2_TAB3	98..138	CDD:270545	13/38 (34%)
		NYD-SP28	528..>602	CDD:291438	21/106 (20%)
		ZnF_RBZ	765..789	CDD:197784
		RanBP2-type Zn finger	767..786	CDD:275376
TAB3	XP_016884888.1	CUE_TAB2_TAB3	9..50	CDD:270545	13/39 (33%)
		TFIIA	122..>291	CDD:281188	46/215 (21%)
		GVQW	634..681	CDD:290611	10/38 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	86	1.000	Domainoid score	I8109
eggNOG	1	0.900	-	-		E1_28IZ6
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	112	1.000	Inparanoid score	I4863
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.950