DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tab2 and TAB2

DIOPT Version :9

Sequence 1:	NP_001246417.1	Gene:	Tab2 / 37216	FlyBaseID:	FBgn0086358	Length:	831	Species:	Drosophila melanogaster
Sequence 2:	NP_001278963.1	Gene:	TAB2 / 23118	HGNCID:	17075	Length:	693	Species:	Homo sapiens

Alignment Length:	858	Identity:	159/858 - (18%)
Similarity:	254/858 - (29%)	Gaps:	346/858 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly   101 LFHEMKQEFPTIPDAIVTQCVNENCHQRENCIQMLRKE---------------------LALHPI 144
            :.|:::|:||.:|:.:|::|:.:|.:..:.|..:|.:|                     |..|..
Human    12 VLHDLRQKFPEVPEVVVSRCMLQNNNNLDACCAVLSQESTRYLYGEGDLNFSDDSGISGLRNHMT 76

  Fly   145 PVQSYPAKVLQQQQQQHH----------------------QNRQAKPPTPLKPSRIAPPQ-PEAV 186
            .:.    ..||.|...||                      |..|:......:..:.||.| |:..
Human    77 SLN----LDLQSQNIYHHGREGSRMNGSRTLTHSISDGQLQGGQSNSELFQQEPQTAPAQVPQGF 137

  Fly   187 LSNGVATPPGVGSPHPD-------------TQPRPR----------------------------P 210
            ...|:::..|..:..|.             :|..||                            |
Human   138 NVFGMSSSSGASNSAPHLGFHLGSKGTSSLSQQTPRFNPIMVTLAPNIQTGRNTPTSLHIHGVPP 202

  Fly   211 TTLNLQRQFSTQLQQKIM----QRQQRQQRDHQPAQLTPTSLSKPLRRAPPLPPPPKPKPGSFSN 271
            ..||..:..|..::..|.    ..:|.||.....:|..|.:..:..:.:.|.|....|.....|:
Human   203 PVLNSPQGNSIYIRPYITTPGGTTRQTQQHSGWVSQFNPMNPQQVYQPSQPGPWTTCPASNPLSH 267

  Fly   272 DSSCLTSPMSSSESELSLNAVPLSSPTSA---AATAAAASAAIASTQ---QQPSPVRHRSVITLQ 330
            .||...:......|.:.:   |:||||::   ...::.:|.:.|.:|   |..|....::.|.::
Human   268 TSSQQPNQQGHQTSHVYM---PISSPTTSQPPTIHSSGSSQSSAHSQYNIQNISTGPRKNQIEIK 329

  Fly   331 PEPPYARDFRSIDFPPTTACTPRLPSPSSAASPSAPGGRKSFTSLNLTLRQPTGSAQSAIDITAG 395
            .|||...:...:     .:..||..|.||           |..|..|...|||      :.|.|.
Human   330 LEPPQRNNSSKL-----RSSGPRTSSTSS-----------SVNSQTLNRNQPT------VYIAAS 372

  Fly   396 PAPSGQGSGITYSSVSFDARRGT-----QKNFQLTVTDEGSVFSAGS------------------ 437
            |..:.:....:...|...|...|     .:|.........|..||.|
Human   373 PPNTDELMSRSQPKVYISANAATGDEQVMRNQPTLFISTNSGASAASRNMSGQVSMGPAFIHHHP 437

  Fly   438 -----------VRPRTLYATPCEPVT---SVPANQQPPPPAAVVADGLGDADMTSDVFPYPTQEQ 488
                       ..||.:...|....|   :|..|:.|.....||:               ||.|.
Human   438 PKSRAIGNNSATSPRVVVTQPNTKYTFKITVSPNKPPAVSPGVVS---------------PTFEL 487

  Fly   489 NHIVASNYSNNHAVSDNNNIGISNSTDSSPTMPLYEGVME-------ECDREARAATIERQKQRR 546
            .:::  |:.:::..::|    |.:.||  ||:...:.:.|       ..|.....|.:..||.|.
Human   488 TNLL--NHPDHYVETEN----IQHLTD--PTLAHVDRISETRKLSMGSDDAAYTQALLVHQKARM 544

  Fly   547 DKLANALRDNKKRLLVLEQEINILTEPVPVGESERLDR-----------DIKQLTEDCNRLL--- 597
            ::|...|...||:|..|:.|:|.:...:   ...||.|           :::|| ..|||.|
Human   545 ERLQRELEIQKKKLDKLKSEVNEMENNL---TRRRLKRSNSISQIPSLEEMQQL-RSCNRQLQID 605

  Fly   598 -DCLNEP----QANGPGPAANPTNRQHLLPASNASQQQPQQQPQPFPRQRQSARVQAPPSSLRLH 657
             |||.:.    ||.||          |..|::                               :|
Human   606 IDCLTKEIDLFQARGP----------HFNPSA-------------------------------IH 629

  Fly   658 S----------VPAAPISQPVQDFGQHHSSAPTSACLTPQMQSQQQLLQLQQEPPPTYAQYYQFQ 712
            :          ||..|..|             .|...||:.|
Human   630 NFYDNIGFVGPVPPKPKDQ-------------RSIIKTPKTQ----------------------- 658

  Fly   713 QYLQQQRQQQLQQQMQQQQQLQHQMQQQQQPQPQQEEEFLSDSDVDEEEETLDSWACNMCTFRNH 777
                                                         |.|::....|.|..|||.||
Human   659 ---------------------------------------------DTEDDEGAQWNCTACTFLNH 678

  Fly   778 PQLNICEACENVR 790
            |.|..||.||..|
Human   679 PALIRCEQCEMPR 691

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tab2	NP_001246417.1	CUE_TAB2_TAB3	98..138	CDD:270545	10/36 (28%)
		NYD-SP28	528..>602	CDD:291438	26/95 (27%)
		ZnF_RBZ	765..789	CDD:197784	13/23 (57%)
		RanBP2-type Zn finger	767..786	CDD:275376	11/18 (61%)
TAB2	NP_001278963.1	CUE_TAB2_TAB3	9..50	CDD:270545	10/37 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	91..130		2/38 (5%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	219..310		20/93 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	330..381		17/72 (24%)
		Mplasa_alph_rch	<537..614	CDD:275316	23/80 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	642..663		9/101 (9%)
		ZnF_RBZ	667..690	CDD:197784	13/22 (59%)
		RanBP2-type Zn finger	668..687	CDD:275376	11/18 (61%)
		Interaction with polyubiquitin	675..685		5/9 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	86	1.000	Domainoid score	I8109
eggNOG	1	0.900	-	-		E1_28IZ6
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	112	1.000	Inparanoid score	I4863
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.950