DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mip40 and LIN37

DIOPT Version :9

Sequence 1:	NP_611407.1	Gene:	mip40 / 37215	FlyBaseID:	FBgn0034430	Length:	267	Species:	Drosophila melanogaster
Sequence 2:	NP_061977.1	Gene:	LIN37 / 55957	HGNCID:	33234	Length:	246	Species:	Homo sapiens

Alignment Length:	230	Identity:	62/230 - (26%)
Similarity:	103/230 - (44%)	Gaps:	36/230 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 LLIQQQQQRQYQVKLDPKVKTVTSGSSEKPSTSSSAAAAGAGGRIKAR---RVLYKKSVGAAAVA 110
            ||.:....|:   :||.:     :|.:...:.:...:.|..|.|..||   :...|:......:|
Human    29 LLEKSHMDRE---RLDEE-----AGKTPSDTHNKDCSIAATGKRPSARFPHQRRKKRREMDDGLA 85

  Fly   111 QKAP--GETYVMRLFERSLDLSKYQDKTPLYPICRAWMANQPK------NPAVGAFQTDASLTAT 167
            :..|  ..|||::||:||:||:::.:.|||||||||||.|.|.      :|:       :.|...
Human    86 EGGPQRSNTYVIKLFDRSVDLAQFSENTPLYPICRAWMRNSPSVRERECSPS-------SPLPPL 143

  Fly   168 KREDNGEEILSQIKSGEIKVINQLPQAKSTD-----LPI-IPPRLEFSQEDKKREKALQGASTSD 226
            ..::.|.|:.:.......|:....|.....|     :|. :.|.::.:.:|:..|..   .|.|.
Human   144 PEDEEGSEVTNSKSRDVYKLPPPTPPGPPGDACRSRIPSPLQPEMQGTPDDEPSEPE---PSPST 205

  Fly   227 LLSSNMNRWKKVRGHWIKHIKKYEKERYEVIDKIM 261
            |:..||.|||::|..| |......:.||....||:
Human   206 LIYRNMQRWKRIRQRW-KEASHRNQLRYSESMKIL 239

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mip40	NP_611407.1	LIN37	108..262	CDD:291952	50/168 (30%)
LIN37	NP_061977.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	37..90		11/60 (18%)
		LIN37	84..240	CDD:405894	50/167 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	129..209		14/89 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159600
Domainoid	1	1.000	74	1.000	Domainoid score	I9235
eggNOG	1	0.900	-	-		E1_28NIZ
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	73	1.000	Inparanoid score	I5292
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48554
OrthoDB	1	1.010	-	-		D1278998at2759
OrthoFinder	1	1.000	-	-		FOG0007984
OrthoInspector	1	1.000	-	-		oto89037
orthoMCL	1	0.900	-	-		OOG6_108733
Panther	1	1.100	-	-	LDO	PTHR31336
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R8951
SonicParanoid	1	1.000	-	-		X5933
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.800