DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fkbp12 and FKBP7

DIOPT Version :9

Sequence 1:	NP_523792.2	Gene:	Fkbp12 / 37214	FlyBaseID:	FBgn0013954	Length:	108	Species:	Drosophila melanogaster
Sequence 2:	NP_851939.1	Gene:	FKBP7 / 51661	HGNCID:	3723	Length:	222	Species:	Homo sapiens

Alignment Length:	102	Identity:	40/102 - (39%)
Similarity:	60/102 - (58%)	Gaps:	4/102 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 PGDGSTYPKNGQKVTVHYTGTL-DDGTKFDSSRDRNK--PFKFTIGKGEVIRGWDEGVAQLSVGQ 71
            |.:.|...|.|..:..||.|.| .||:||..||.:|:  |..|.:|.|:||:|.|..:..:..|:
Human    43 PENCSKTSKKGDLLNAHYDGYLAKDGSKFYCSRTQNEGHPKWFVLGVGQVIKGLDIAMTDMCPGE 107

  Fly    72 RAKLICSPDYAYGSRGH-PGVIPPNSTLTFDVELLKV 107
            :.|::..|.:|||..|: .|.|||::||.|::||..|
Human   108 KRKVVIPPSFAYGKEGYAEGKIPPDATLIFEIELYAV 144

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fkbp12	NP_523792.2	FkpA	<2..107	CDD:223619	39/100 (39%)
FKBP7	NP_851939.1	FKBP_C	46..141	CDD:306713	36/94 (38%)
		EF-hand_7	152..214	CDD:316058
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	200..222
		Retention in the endoplasmic reticulum. /evidence=ECO:0000255\|PROSITE-ProRule:PRU10138	219..222
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0545
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810