DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fkbp12 and fkbp8

DIOPT Version :9

Sequence 1:	NP_523792.2	Gene:	Fkbp12 / 37214	FlyBaseID:	FBgn0013954	Length:	108	Species:	Drosophila melanogaster
Sequence 2:	NP_957178.1	Gene:	fkbp8 / 393858	ZFINID:	ZDB-GENE-040426-1849	Length:	406	Species:	Danio rerio

Alignment Length:	93	Identity:	31/93 - (33%)
Similarity:	52/93 - (55%)	Gaps:	5/93 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 PKNGQKVTVHYTGTLDDGTKFDSSRDRNKPFKFTIGKGEVIRGWDEGVAQLSVGQRAKLICSPDY 81
            |:.||.||:|....|.:||..|..:|    ..||:|.|:|::..|..|..:.:|::|.:..:..|
Zfish   109 PQKGQNVTIHLKTALTNGTVVDELKD----LSFTLGDGDVLQALDLTVQLMEMGEKALIEAAAKY 169

  Fly    82 AYGSRGHPG-VIPPNSTLTFDVELLKVE 108
            |||:.|... .:||::.|..:|:||..:
Zfish   170 AYGALGSSAPAVPPDADLLLEVQLLSAD 197

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fkbp12	NP_523792.2	FkpA	<2..107	CDD:223619	31/90 (34%)
fkbp8	NP_957178.1	FKBP_C	106..194	CDD:278674	29/88 (33%)
		TPR_11	214..296	CDD:290150
		TPR repeat	214..259	CDD:276809
		TPR repeat	265..293	CDD:276809
		TPR_11	266..330	CDD:290150
		TPR repeat	298..328	CDD:276809
		TPR_1	299..332	CDD:278916
		TPR repeat	333..361	CDD:276809
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0545
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900