DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fkbp12 and Fkbp10

DIOPT Version :9

Sequence 1:	NP_523792.2	Gene:	Fkbp12 / 37214	FlyBaseID:	FBgn0013954	Length:	108	Species:	Drosophila melanogaster
Sequence 2:	NP_034351.2	Gene:	Fkbp10 / 14230	MGIID:	104769	Length:	581	Species:	Mus musculus

Alignment Length:	88	Identity:	42/88 - (47%)
Similarity:	53/88 - (60%)	Gaps:	0/88 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 GQKVTVHYTGTLDDGTKFDSSRDRNKPFKFTIGKGEVIRGWDEGVAQLSVGQRAKLICSPDYAYG 84
            |..|..||.||.:||.|||||.||:......:|.|.:|.|.|.|:..:.|.:|.:||..|...||
Mouse    61 GDFVRYHYNGTFEDGKKFDSSYDRSTLVAIVVGVGRLITGMDRGLMGMCVNERRRLIVPPHLGYG 125

  Fly    85 SRGHPGVIPPNSTLTFDVELLKV 107
            |.|..|:|||::||.|||.||.|
Mouse   126 SIGVAGLIPPDATLYFDVVLLDV 148

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fkbp12	NP_523792.2	FkpA	<2..107	CDD:223619	41/86 (48%)
Fkbp10	NP_034351.2	FKBP_C	54..146	CDD:278674	39/84 (46%)
		FKBP_C	166..258	CDD:278674
		FKBP_C	278..370	CDD:278674
		FKBP_C	391..482	CDD:278674
		EF-hand_7	504..567	CDD:290234
		EFh	505..566	CDD:238008
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	533..581
		Prevents secretion from ER. /evidence=ECO:0000255\|PROSITE-ProRule:PRU10138	578..581
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0545
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810