Protein Alignment CG10474 and AGA

DIOPT Version :9

• Sequence 1: NP_611404.1
• Gene: CG10474 / 37211
• FlyBaseID: FBgn0034427
• Length: 341
• Species: Drosophila melanogaster
• Sequence 2: NP_000018.2
• Gene: AGA / 175
• HGNCID: 318
• Length: 346
• Species: Homo sapiens
• Alignment Length: 331
• Identity: 167/331 - (50%)
• Similarity: 212/331 - (64%)
• Gaps: 21/331 - (6%)

  Fly     1 MVINTWPFAEAKKEAWRLLNVKKGGLGQTRSAVVGGISMCEKLQCAKTVGYGGNPDERGDTSLDA 65
            :|:|||||..|.:.|||.|    ...|....||..|.:|||:.||..:||:||:|||.|:|:|||
Human    29 LVVNTWPFKNATEAAWRAL----ASGGSALDAVESGCAMCEREQCDGSVGFGGSPDELGETTLDA 89

  Fly    66 LLMDGGTMEVGAVGDLRRIRSAIKVAQHVLEHTLHTLLVGDGADEFANAMGLQYESLNSEDNIES 130
            ::|||.||:||||||||||::||.||:.|||||.||||||:.|..||.:||...|.|::..:...
Human    90 MIMDGTTMDVGAVGDLRRIKNAIGVARKVLEHTTHTLLVGESATTFAQSMGFINEDLSTTASQAL 154

  Fly   131 LKNWTRHNCQPNFWRNVHPDPRTSCGPYQP--LVTWD-PNAKQS--DRIEIGPDNHDTITMAAID 190
            ..:|...|||||:||||.|||...||||:|  ::..| |..|::  ||      .||||.|..|.
Human   155 HSDWLARNCQPNYWRNVIPDPSKYCGPYKPPGILKQDIPIHKETEDDR------GHDTIGMVVIH 213

  Fly   191 EEGHIHVGTSTNGLRYTLPGRVGDASIPGSAAYADNEVGAAVTTGDGDILMRFLPSLLAVEAMRA 255
            :.|||..||||||:::.:.|||||:.|||:.||||:..|||..||:||||||||||..|||.||.
Human   214 KTGHIAAGTSTNGIKFKIHGRVGDSPIPGAGAYADDTAGAAAATGNGDILMRFLPSYQAVEYMRR 278

  Fly   256 GKTPAEAVELVIQRIQKHVKYFEVAVIVANRLGTYAVRCHGTGMARDNGKFAYMV--SSPGQPVR 318
            |:.|..|.:.||.|||||...|..|||.||..|:|...|:......   :|::||  |...||..
Human   279 GEDPTIACQKVISRIQKHFPEFFGAVICANVTGSYGAACNKLSTFT---QFSFMVYNSEKNQPTE 340

  Fly   319 TESVEC 324
             |.|:|
Human   341 -EKVDC 345

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10474	NP_611404.1	Glycosylasparaginase	1..312	CDD:271335	161/317 (51%)
AGA	NP_000018.2	Glycosylasparaginase	29..332	CDD:271335	161/315 (51%)
		Substrate binding. /evidence=ECO:0000269|PubMed:8846222	234..237		2/2 (100%)
		Substrate binding. /evidence=ECO:0000269|PubMed:8846222	257..260		2/2 (100%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141712
Domainoid	1	1.000	318	1.000	Domainoid score	I1254
eggNOG	1	0.900	-	-		E1_COG1446
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H13
Inparanoid	1	1.050	340	1.000	Inparanoid score	I2371
Isobase	1	0.950	-	0	Normalized mean entropy	S3395
OMA	1	1.010	-	-		QHG58368
OrthoDB	1	1.010	-	-		D1487354at2759
OrthoFinder	1	1.000	-	-		FOG0004212
OrthoInspector	1	1.000	-	-		otm40941
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10188
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3475
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.820