Protein Alignment CG11906 and ZNF347

DIOPT Version :10

• Sequence 1: NP_611402.2
• Gene: CG11906 / 37209
• FlyBaseID: FBgn0034425
• Length: 634
• Species: Drosophila melanogaster
• Sequence 2: NP_001166145.1
• Gene: ZNF347 / 84671
• HGNCID: 16447
• Length: 840
• Species: Homo sapiens
• Alignment Length: 622
• Identity: 130/622 - (20%)
• Similarity: 215/622 - (34%)
• Gaps: 138/622 - (22%)

  Fly    11 PSSTNGNCSVEHDNRQDQDENHVGAEREAEANDA--NCTVCGAAKASALLDLRSNHVMQRRLSRD 73
            |..:||...|...|      :|:.:.:.:...:.  .|..||.|     ...|||      |:..
Human   261 PYKSNGCGMVFPQN------SHLASHQRSHTKEKPYKCYECGKA-----FRTRSN------LTTH 308

  Fly    74 WKIHADVIRSTLKAICVECVCKLNMHSEVTRSLMQRMQRLQRSGGETTKVTTTTTSPSQHSPPIA 138
            ..||....|..    |.||....:.:|::::..............|..||.|      |:|..:.
Human   309 QVIHTGEKRYK----CNECGKVFSRNSQLSQHQKIHTGEKPYKCNECGKVFT------QNSHLVR 363

  Fly   139 DAEVSTTLIESQEEVAHSGQSVRSRSSCSVLE-VYLAQQPYSPSAKE-----TEEKH-AEGWKWR 196
            ...:.|.  |...:....|::.|:|||.::.: .:..::||  ...|     |:..| ...|:..
Human   364 HRGIHTG--EKPYKCNECGKAFRARSSLAIHQATHSGEKPY--KCNECGKVFTQNSHLTNHWRIH 424

  Fly   197 T---RLECHECGRAYFRRDYYAQHL-----------RRCSKTRRKQPRPSRVKCRVLNEASYDEE 247
            |   ..:|:|||:|:..|...|.||           ..|.|..|:....:|      ::..:..|
Human   425 TGEKPYKCNECGKAFGVRSSLAIHLVIHTGEKPYKCHECGKVFRRNSHLAR------HQLIHTGE 483

  Fly   248 APSRAIRSSRIYYCRHCDAEFETLISKRQHERM-KHQ------QRYPCDLCEAQLDTKYEWEMH- 304
            .|         |.|..|...|      |.|..: .||      :.|.|:.|............|
Human   484 KP---------YKCNECGKAF------RAHSNLTTHQVIHTGEKPYKCNECGKVFTQNSHLANHQ 533

  Fly   305 --HT-----ICQAKQEALAIVEQQEAGQTVMTSRVPRACSMRSRSRACSEAWDRYDMDEEEEDEE 362
              ||     :|....:|.::.......|.:.|...|..|:      .|.:.:     .:......
Human   534 RIHTGVKPYMCNECGKAFSVYSSLTTHQVIHTGEKPYKCN------ECGKVF-----TQNSHLAR 587

  Fly   363 DEEIESGGEELEEGEEDAMYARRMNFTGDWIVNHSRSNSNSAGNLSLLYGDYGM-------VETH 420
            ...|.:|.:..:..|...::  |.|   .::..|.|.::   |.....|.:||.       :.||
Human   588 HRGIHTGEKPYKCNECGKVF--RHN---SYLSRHQRIHT---GEKPYKYNEYGKAFSEHSNLTTH 644

  Fly   421 M---TTDKEY-----------DLYLLDLLKTQVRLKSFTCFTPDCGYQTDTLVALMKHDYMEHWK 471
            .   |.:|.|           :.:|....:.....|.:.|  .:||........|.:|..: |..
Human   645 QVIHTGEKPYKCNECGKVFTQNSHLARHRRVHTGGKPYQC--NECGKAFSQTSKLARHQRV-HTG 706

  Fly   472 MSWFYCHKCGDVFTSKVFLDYHMHLQ-NRGLYICHKCREEFELQHQLDRHFQLHRKGINYHCNFC 535
            ...:.|::||..|:.:..|..|..:. .:..|.|::|.:.|.....|.||..:|.....|.||.|
Human   707 EKPYECNQCGKAFSVRSSLTTHQAIHTGKKPYKCNECGKVFTQNSHLARHRGIHTGEKPYKCNEC 771

  Fly   536 RLEFLSEAKLLAHCK-KLGHSPND--EPLISIDRSLS 569
            ...|...:||..|.: ..|..|.:  :| .||..||:
Human   772 GKAFSQTSKLARHQRIHTGEKPYECGKP-FSICSSLT 807

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG11906	NP_611402.2	None
ZNF347	NP_001166145.1	KRAB	8..67	CDD:214630
		C2H2 Zn finger	265..284	CDD:275368	5/24 (21%)
		COG5048	273..728	CDD:227381	102/528 (19%)
		C2H2 Zn finger	292..312	CDD:275368	8/30 (27%)
		C2H2 Zn finger	320..340	CDD:275368	4/19 (21%)
		C2H2 Zn finger	348..368	CDD:275368	6/25 (24%)
		C2H2 Zn finger	376..396	CDD:275368	5/19 (26%)
		C2H2 Zn finger	404..424	CDD:275368	4/19 (21%)
		C2H2 Zn finger	432..452	CDD:275368	9/19 (47%)
		C2H2 Zn finger	460..480	CDD:275368	4/25 (16%)
		C2H2 Zn finger	488..508	CDD:275368	7/25 (28%)
		C2H2 Zn finger	516..536	CDD:275368	3/19 (16%)
		C2H2 Zn finger	544..564	CDD:275368	3/19 (16%)
		C2H2 Zn finger	572..592	CDD:275368	2/30 (7%)
		C2H2 Zn finger	600..620	CDD:275368	5/24 (21%)
		C2H2 Zn finger	628..648	CDD:275368	5/19 (26%)
		C2H2 Zn finger	656..676	CDD:275368	1/19 (5%)
		C2H2 Zn finger	684..704	CDD:275368	5/22 (23%)
		C2H2 Zn finger	712..732	CDD:275368	6/19 (32%)
		COG5048	723..>817	CDD:227381	25/86 (29%)
		C2H2 Zn finger	740..760	CDD:275368	6/19 (32%)
		C2H2 Zn finger	768..788	CDD:275368	7/19 (37%)
		C2H2 Zn finger	795..813	CDD:275368	5/14 (36%)