DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tbrd-2 and RSC4

DIOPT Version :9

Sequence 1:	NP_611401.2	Gene:	tbrd-2 / 37207	FlyBaseID:	FBgn0034423	Length:	674	Species:	Drosophila melanogaster
Sequence 2:	NP_012933.4	Gene:	RSC4 / 853877	SGDID:	S000001716	Length:	625	Species:	Saccharomyces cerevisiae

Alignment Length:	516	Identity:	96/516 - (18%)
Similarity:	175/516 - (33%)	Gaps:	161/516 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 LHYFKKHLLDEARKK------------------KYALDFLEPVDTEALMVPTYYTVIHRPMDIGT 81
            |||..| |:|...||                  |.:..|:|.||.:.|  |.||.::|.||.:..
Yeast   176 LHYLNK-LVDATEKKINQALLGASSPKNLDDKVKLSEPFMELVDKDEL--PEYYEIVHSPMALSI 237

  Fly    82 IVKRVQNNYYKSVNEAIADFKQIISNCFLFNRSGDVVYRK--------GQMLEKFFHKKLRGMPS 138
            :.:.::...|..:.:.|.|...:..|..:||....::|:.        ..:::|.|..:|:.:..
Yeast   238 VKQNLEIGQYSKIYDFIIDMLLVFQNAHIFNDPSALIYKDATTLTNYFNYLIQKEFFPELQDLNE 302

  Fly   139 GPEVPCNRDP------KAVGRPRTNAPSSAQTERKCRELLKKLQSITNQTDAMTRNFFSNKWDSL 197
            ..|:....|.      .|:|   ...|::|..        ..:.::.|..:..     ||:.|.:
Yeast   303 RGEINLEFDKFEFENYLAIG---GGGPAAAGA--------LAISALDNDIEPE-----SNREDLI 351

  Fly   198 -QKKVDRQYFKSVNEFCLHVDGCFRKYHEPAKILYERVFNQPAAWCTSMNG-NSSL---ESALNA 257
             |...|..:|:.:.                                   || |.||   :..||.
Yeast   352 DQADYDFNHFEGLG-----------------------------------NGYNRSLLTEDYLLNP 381

  Fly   258 ADLNELLAAAKLTVNSLMQCVQMPGSGEPLTAKSLVETFCDTLNKMINKMEAGQRNSPN----PS 318
            .:..:|:|..        :.||.....|..|...:.:|         |.:|:.....|.    .|
Yeast   382 NNFKKLIAKP--------ETVQSEVKNERSTTSDIEKT---------NSLESEHLKIPKYNVIKS 429

  Fly   319 SSKRQKMSPEQETDLVQGEFKPAMELLSGNEIDNLMAVSIESSDDEAIDASMRITDADRCATQKL 383
            ..|..:...||.|    .|:|| .:|:  .:|....:.::.|.                 ||:.|
Yeast   430 MQKEMQSLSEQHT----MEYKP-YKLI--QQIYIFSSKNLYSQ-----------------ATKPL 470

  Fly   384 FAKLPT---NAMKEIIH-------------MVQQIEGFSSENCGDLSFDVKGLATDTMIMMKSAV 432
            ....|:   |.::.|.:             |:|.::.|.:.. ..|:..:|.  |:|::.:....
Yeast   471 LGSRPSCNQNWVEYIFNGNELSQNENAFSFMLQPMQTFLTLQ-SHLTSSLKD--TETLLTINKEP 532

  Fly   433 TKATRAHSKLKLKDMQPSEKEGLQRALQSQLVNITRMLNKNRRRCGPLINFRNKNNTANNV 493
            .|:..::....|...|..|.:.:....:..:.|:|.....|....|      |.|:..||:
Yeast   533 VKSRTSNVNSNLSQPQQQENDVIGNDTKQDIENLTIGGGNNNDIVG------NDNDKRNNI 587

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tbrd-2	NP_611401.2	Bromo_gcn5_like	34..136	CDD:99941	30/126 (24%)
RSC4	NP_012933.4	COG5076	40..423	CDD:227408	59/317 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900