DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tbrd-2 and ITC1

DIOPT Version :9

Sequence 1:	NP_611401.2	Gene:	tbrd-2 / 37207	FlyBaseID:	FBgn0034423	Length:	674	Species:	Drosophila melanogaster
Sequence 2:	NP_011382.1	Gene:	ITC1 / 852744	SGDID:	S000003101	Length:	1264	Species:	Saccharomyces cerevisiae

Alignment Length:	744	Identity:	126/744 - (16%)
Similarity:	237/744 - (31%)	Gaps:	193/744 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 KPLSVKLKLPNRVQPEFIPHPG----MAGRYTNKLHYFKKHLLDEARKKKYALDFLEPVDTEALM 65
            |||.:.|    .||...|...|    ....:..:..::.:|...........|.|.:.:|:|.
Yeast    15 KPLPLDL----NVQVWHIEETGEWFSSYEEFLERFDFYTRHHFTCEITGTSCLTFFQALDSEE-- 73

  Fly    66 VPTYYTVIHRPMDIGTIVKRVQNNYYKSVNEAIADFKQI----------------ISNCFLFNRS 114
                           |..|.|::.:...:.|.:|.|...                ..|.|.   .
Yeast    74 ---------------TQFKYVEDRFPLKLREPVARFLHFNGIRRLDALVEKVYARFKNDFF---P 120

  Fly   115 GDVVYRKGQMLEKFFHKKLRGMPSGPEVPCNRDPKAVGRP-------------RTNAPSSAQTER 166
            |:|||.:.|  :...........|.|:.....:..:||.|             :.....:|....
Yeast   121 GEVVYLRKQ--KDSSTTSSNSQQSTPQPDDMVEINSVGNPGLPQYQYQRRYVIKEKVQFNATINP 183

  Fly   167 KCRELLKKLQS---ITNQTDAMTRNFFSNKWDSLQKKVDR-QYFKSVNEFCLHVDGCFRKYHEPA 227
            :.||::....:   :..:..:..::|.          ||: |.::..:.|..|:..||      .
Yeast   184 ESREIVMPAHTKYMLIEEAASSNKSFI----------VDQGQIYRDRSTFTKHLIKCF------F 232

  Fly   228 KILYERVFNQPAA-WCTSMNGNSSLESALNAADLNELLAAAKLTVNSLMQCVQMPGSGEPLTAKS 291
            ||..:|..::..| ||..                .|.||...||:......::.. ..||:.|:.
Yeast   233 KITLQRASSKMGAPWCVK----------------PEYLAMYGLTMEWPKDMLKYK-EDEPVVARR 280

  Fly   292 LVETFCDTLNKMINKME---AGQRNSPNPSSSKRQKMSPEQETDL-----------------VQG 336
            .......:.....||.:   :|:.|:.|.:|:|::.....:.|::                 |..
Yeast   281 SNSANVSSPESEKNKRQSKSSGKSNTSNDASNKKETKKKRKPTEVNDSENNSSEEDKKKGQNVTS 345

  Fly   337 EFKPAMELLSGNEIDNLMAVSIESSDDEAIDASMRITDADRCATQKLFAKLPTNAMKEIIHMVQQ 401
            |..........||..|  ..::||....|......:|.........|..:.|.|....:.:..::
Yeast   346 ETHSKKRKKEANEEPN--TENVESVPTPANAEPQAVTITSIMDDLALPYQHPPNIFPNLTYYNEK 408

  Fly   402 IEGFSSENCGDLS--FDVKGLATDTMIMMKSAVTKATRAHSKL-----KLKDMQPSEKEGLQRAL 459
            :|..|..:. .||  ||..|........:.:..:|...:|..|     .||...|.|.:|
Yeast   409 LECISLGST-KLSRPFDSFGKLLQAYQFLNTFGSKICLSHFSLDQFITSLKCTDPYELKG----- 467

  Fly   460 QSQLVNITRMLNKNRRRCGPLINFRNK-----------------NNTANNVVRKRATAPLTAKLK 507
            :..||||....:|.:......:..:||                 |:...:::.||.:..:..|:
Yeast   468 EVVLVNIRTQTSKEQEIENNGLPMKNKAETTTEEDSENPSDWQRNSFIRDMIMKRNSDKVEYKI- 531

  Fly   508 PLQANVMAPQLGAGVVETHNLSDTSDDDVSAPVKLSAIGGTPMRNLPINSNPLQMQPIRSPPKL- 571
                             .|:  |.:.||:             :.|:..|.:.|.::...:..:|
Yeast   532 -----------------VHD--DPASDDI-------------LDNINHNGSALLIEVFTALLRLF 564

  Fly   572 --------PHVVELQMSSSSSSESEMKSKSGRLSRSRSRSMSDTKLRPRSNSSASSRSNSSSSSG 628
                    ..|||..:........|.|.:.|.....:.|:.....|:.:  ....:..::...:.
Yeast   565 INEEGDWSCIVVENWIIDDKGVLMERKDERGEGEAKQKRNAHGYFLQDK--EKIDNLKDTLKENA 627

  Fly   629 SNAGSSSGSRSRSSSSSSSSSNNSSESND 657
            :.....|.:::.::|.|.|.|::.||..|
Yeast   628 TEVQKESDAKNETNSESDSKSDSDSEERD 656

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tbrd-2	NP_611401.2	Bromo_gcn5_like	34..136	CDD:99941	18/117 (15%)
ITC1	NP_011382.1	WAC_Acf1_DNA_bd	24..124	CDD:402251	17/119 (14%)
		DDT	423..483	CDD:214726	16/64 (25%)
		WSD	869..952	CDD:406128
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900