DRSC/TRiP Functional Genomics Resources

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Protein Alignment tbrd-2 and BRD3

DIOPT Version :9

Sequence 1:NP_611401.2 Gene:tbrd-2 / 37207 FlyBaseID:FBgn0034423 Length:674 Species:Drosophila melanogaster
Sequence 2:NP_031397.1 Gene:BRD3 / 8019 HGNCID:1104 Length:726 Species:Homo sapiens


Alignment Length:801 Identity:156/801 - (19%)
Similarity:278/801 - (34%) Gaps:244/801 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly    14 PNRVQPEFIPHPGMAGRYTNKLHYFKKHLLDEARKKKYALDFLEPVDTEALMVPTYYTVIHRPMD 78
            |....|..:.:|...||.||:|.|.:..::....|.::|..|.:|||...|.:|.|:.:|..|||
Human    18 PVNPPPPEVSNPSKPGRKTNQLQYMQNVVVKTLWKHQFAWPFYQPVDAIKLNLPDYHKIIKNPMD 82

  Fly    79 IGTIVKRVQNNYYKSVNEAIADFKQIISNCFLFNRSGDVVYRKGQMLEKFFHKKLRGMPSGPEVP 143
            :|||.||::||||.|.:|.:.||..:.:||:::|:..|.:....|.|||.|.:|:..||......
Human    83 MGTIKKRLENNYYWSASECMQDFNTMFTNCYIYNKPTDDIVLMAQALEKIFLQKVAQMPQEEVEL 147

  Fly   144 CNRDPKAVGRPRTNAPSSAQTERKCRELLKKLQSITNQTDAMTRNFFSNKWDSLQKKVDRQYFKS 208
            ....||..||.......||.|                                            
Human   148 LPPAPKGKGRKPAAGAQSAGT-------------------------------------------- 168

  Fly   209 VNEFCLHVDGCFRKYHEPAKILYERVFNQPAAWCTSMNGNSSLESALNAADLNELLAAAKL-TVN 272
                                        |..|..:|::..:..:|.........::||..: |:.
Human   169 ----------------------------QQVAAVSSVSPATPFQSVPPTVSQTPVIAATPVPTIT 205

  Fly   273 SLMQCVQMPGSG----------------EPLTAKSLVETFCDTLNKMINKMEAGQRNSPNP-SSS 320
            :.:..|.:|.:.                .|:..|..|:...||.....:.:.|.:..||.| |..
Human   206 ANVTSVPVPPAAAPPPPATPIVPVVPPTPPVVKKKGVKRKADTTTPTTSAITASRSESPPPLSDP 270

  Fly   321 KRQKMSPEQET----------DLVQGE-------------------------------------F 338
            |:.|:...:|:          ||..||                                     :
Human   271 KQAKVVARRESGGRPIKPPKKDLEDGEVPQHAGKKGKLSEHLRYCDSILREMLSKKHAAYAWPFY 335

  Fly   339 KP----AMEL-------------------LSGNEIDNLMAVSIE------------SSDDEAIDA 368
            ||    |:||                   :.|.|..:....:.:            ..|.|.:..
Human   336 KPVDAEALELHDYHDIIKHPMDLSTVKRKMDGREYPDAQGFAADVRLMFSNCYKYNPPDHEVVAM 400

  Fly   369 SMRITDADRCATQKLFAKLPTNAMK---------EIIHMVQQIEGFSSENCGD------------ 412
            :.::.|    ..:..|||:|...::         .::....:....|.|:..|            
Human   401 ARKLQD----VFEMRFAKMPDEPVEAPALPAPAAPMVSKGAESSRSSEESSSDSGSSDSEEERAT 461

  Fly   413 ----LSFDVKGLATDTMIMMKSAVTKATRAHSK----LKLKDMQPSEKEGLQRALQSQLVNITRM 469
                |...:|.:......:.::.|.|..:...|    .|.||.:..:::...:|.:.:...:...
Human   462 RLAELQEQLKAVHEQLAALSQAPVNKPKKKKEKKEKEKKKKDKEKEKEKHKVKAEEEKKAKVAPP 526

  Fly   470 LNKNRRRCGPLINFRNKNNTANNVVR---KRATA-----------PLTAKLK---PLQAN-VMAP 516
            ..:.:::..| ....|...||...::   |:|:|           |::...|   .|..| :...
Human   527 AKQAQQKKAP-AKKANSTTTAGRQLKKGGKQASASYDSEEEEEGLPMSYDEKRQLSLDINRLPGE 590

  Fly   517 QLG--AGVVETH--NLSDTSDDDVSAPVKLSAIGGTPMRNLPINSNPLQMQPIRSPPKLPHVVEL 577
            :||  ..::::.  :|.|::.|::.  :....:..|.:|.|.........:..|.|         
Human   591 KLGRVVHIIQSREPSLRDSNPDEIE--IDFETLKPTTLRELERYVKSCLQKKQRKP--------- 644

  Fly   578 QMSSSSSSESEMKSKSGRLSRSRSRSMSDTKLRPRSNSSASSRSNSSSSSGSNAGSSSGSR-SRS 641
              .|:|..:...|||. .|::.:.:.: :.:|:..|...:||:..:......:|.|...|| |.|
Human   645 --FSASGKKQAAKSKE-ELAQEKKKEL-EKRLQDVSGQLSSSKKPARKEKPGSAPSGGPSRLSSS 705

  Fly   642 SSSSSSSSNNSSESNDSSDVE 662
            |||.|.||::|..|:||||.|
Human   706 SSSESGSSSSSGSSSDSSDSE 726

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
tbrd-2NP_611401.2 Bromo_gcn5_like 34..136 CDD:99941 38/101 (38%)
BRD3NP_031397.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..35 4/16 (25%)
Bromo_Brdt_I_like 34..140 CDD:99929 41/105 (39%)
Acetylated histone H3 binding. /evidence=ECO:0000269|PubMed:27105114 78..80 0/1 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 149..169 7/91 (8%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 237..305 16/67 (24%)
Bromo_Brdt_II_like 311..412 CDD:99930 10/104 (10%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 421..462 3/40 (8%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 477..575 15/98 (15%)
BET 571..635 CDD:293640 12/65 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 637..726 30/101 (30%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5076
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
21.860

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