DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tbrd-2 and cecr2

DIOPT Version :9

Sequence 1:	NP_611401.2	Gene:	tbrd-2 / 37207	FlyBaseID:	FBgn0034423	Length:	674	Species:	Drosophila melanogaster
Sequence 2:	XP_005174419.1	Gene:	cecr2 / 799918	ZFINID:	ZDB-GENE-131121-533	Length:	1502	Species:	Danio rerio

Alignment Length:	682	Identity:	128/682 - (18%)
Similarity:	212/682 - (31%)	Gaps:	195/682 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 LLDEARKKKYALDFLEPVDTEALMVPTYYTVIHRPMDIGTIVKRVQNNYYKSVNEAIADFKQIIS 106
            :|:..:..|.|..|:||||..  ..|.|:.:|..|||:.||.:::.:..|.:.:|.:||.|.:..
Zfish   411 VLEALKAHKDAWPFMEPVDES--YAPNYHEIIQTPMDLSTIERKLNDGEYLAKDEFVADVKLMFG 473

  Fly   107 NCFLFNRSGDVVYRKGQMLEKFFHKKLRGMPSGPEVPCNRDPKAVGRPRTNAPSSAQTERKCREL 171
            ||..:|..........:.||:.|                                      .|.|
Zfish   474 NCLEYNGEESEYTIMAESLERCF--------------------------------------TRAL 500

  Fly   172 LKKLQSITNQTDAMTRNFFSNKWDSLQKKVDRQYFKSVNEFCLHV-------------DGCFRKY 223
            ||...|....||   ..|..:..|...||.::.:.:|..|..:..             .|..::.
Zfish   501 LKHFPSEDGDTD---EEFHVSSEDRKDKKKNKNHKQSGPESLIRATEQVQKRKTSNSGKGNNQQQ 562

  Fly   224 HEPAKILYERVFNQPAAWCTSMNG---------NSSLESALNAADLNELLAAAKLTVNSLMQCVQ 279
            .:|...|      ||.....| ||         .......|:.|...:..:...:....:|...|
Zfish   563 EKPKSTL------QPPPPHYS-NGPPHPHNIHPGQQQRGMLHPAQQFQRPSGPGMYAQHMMIDAQ 620

  Fly   280 MPGSGE-PLTAK-------SLVETFCDTLNKMINKMEAGQRNSPNPSSSKRQKMSPEQETDLVQG 336
            .|..|: ||.::       ..|..| :.....||....|.|.:..|.....|  .|.|:......
Zfish   621 YPYPGQRPLISRPPGDHENQHVPHF-NMQGSHINGPHLGTRYTVGPDGQPLQ--PPHQQHSYSGP 682

  Fly   337 EFKPAMELLSGNEIDNLMAVSIESSDDEAIDASMRITDADRCATQKLFAKLPTNAMKEIIHMVQQ 401
            ...|::.                       ...|.:.....|:........|::         |.
Zfish   683 THGPSLG-----------------------PRPMALQPGGLCSPPPEGNMYPSH---------QH 715

  Fly   402 IEGFSSENCGDLSFDVKGLATDTMIMMKSAVTK-ATRAHSKLKLKDMQPSEKEGLQRALQSQLVN 465
            .||                  .:|..|.:|.|: ....||     ...|....|:         |
Zfish   716 PEG------------------QSMRPMGNAYTRPGVPMHS-----SYPPYGPHGM---------N 748

  Fly   466 ITRMLNKNRRRCGPLINFRNKNNTANNVVRKRATAPLTAKLKPLQANVMAPQLGAGVVETHNLSD 530
            |.||        .|.:|.:.:...:.|::::    |..:...|...|::..|...|....:....
Zfish   749 IPRM--------WPPMNHQRQPTPSGNMMQE----PSASGQHPYNHNMIHSQNSTGFTMANGQFK 801

  Fly   531 TSDDDVSAPVKLSAIGGTPMRNLPINSNPLQMQPIRSPPKLPHVVELQMSSSSSS------ESEM 589
            ....:...||.....||.....|          .:.|....|.::.||..|:|||      :|..
Zfish   802 MPSANSQGPVGQKLQGGPQASRL----------HLASMLDSPEMIALQQLSASSSHHVGNFQSPQ 856

  Fly   590 KSKSGRLSRSRSRS--------MSDTKLRPRSNSSASSRSNSSSSSGSNAGSSSGSRSRSSSSSS 646
            :|....|:.:...|        ..|.:..|.|:..:|.:|.:..|:|..:.:.:.|||..|::..
Zfish   857 QSGGNPLASAEQSSPEKQLHMPSRDKQHTPVSSKGSSPKSGNKMSTGEISLTEAESRSYPSTTEK 921

  Fly   647 SS-----------SNNSSESNDSSDVEVVPNV 667
            |.           |:.|.|.|.:.|...:.|:
Zfish   922 SEQPSQVTGLASVSSPSKELNQNEDKHRLSNL 953

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tbrd-2	NP_611401.2	Bromo_gcn5_like	34..136	CDD:99941	27/93 (29%)
cecr2	XP_005174419.1	DDT	23..63	CDD:280886
		ARGLU	202..366	CDD:291991
		Bromo_gcn5_like	403..503	CDD:99941	30/131 (23%)
		Med15	675..>1110	CDD:255446	63/365 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900