Protein Alignment tbrd-2 and BRDT

DIOPT Version :10

• Sequence 1: NP_611401.2
• Gene: tbrd-2 / 37207
• FlyBaseID: FBgn0034423
• Length: 674
• Species: Drosophila melanogaster
• Sequence 2: NP_001229735.2
• Gene: BRDT / 676
• HGNCID: 1105
• Length: 951
• Species: Homo sapiens
• Alignment Length: 758
• Identity: 182/758 - (24%)
• Similarity: 304/758 - (40%)
• Gaps: 151/758 - (19%)

  Fly    11 LKLPNR--------VQPEFIPHPGMAGRYTNKLHYFKKHLLDEARKKKYALDFLEPVDTEALMVP 67
            :.||:|        ..||:| :....||.||:|.|.:|.:|.:..|..::..|..|||...|.:|
Human     1 MSLPSRQTAIIVNPPPPEYI-NTKKNGRLTNQLQYLQKVVLKDLWKHSFSWPFQRPVDAVKLQLP 64

  Fly    68 TYYTVIHRPMDIGTIVKRVQNNYYKSVNEAIADFKQIISNCFLFNRSGDVVYRKGQMLEKFFHKK 132
            .|||:|..|||:.||.||::|.||...:|.|.||..:.|||:|:|:.||.:....|.|||.|.:|
Human    65 DYYTIIKNPMDLNTIKKRLENKYYAKASECIEDFNTMFSNCYLYNKPGDDIVLMAQALEKLFMQK 129

  Fly   133 LRGMPSGPEVPCNRD----PKAVGRPRTNAPSSAQ-------TERKCRELLKKLQSITNQTDAMT 186
            |..||...:|...::    .||.|..:..|.|||:       ||:..::  :::.|:..:|....
Human   130 LSQMPQEEQVVGVKERIKKGKAGGTQQNIAVSSAKEKSSPSATEKVFKQ--QEIPSVFPKTSISP 192

  Fly   187 RNFFSNKWDSLQKKVDRQYFKSVNEFCLHVDGCFRKYHE--------PAKILYERVFNQPAAWCT 243
            .|.......:...:...|..|.|.          ||...        .|...:...|.:.:....
Human   193 LNVVQGASVNSSSQTAAQVTKGVK----------RKADTTTPATSAVKASSEFSPTFTEKSVALP 247

  Fly   244 SMNGNSSLESALNAADLNELLAAAKLTVNSLMQCVQMPGSGEPLTAK--SLVETFCDTLNKMINK 306
            .:..|.......::.....::...|:| ..|..|.::  ..|.|..|  |....|.:.::  :|.
Human   248 PIKENMPKNVLPDSQQQYNVVKTVKVT-EQLRHCSEI--LKEMLAKKHFSYAWPFYNPVD--VNA 307

  Fly   307 MEAGQRN------SPNPSSSKRQKMSPEQETDLVQGEFKPAMELLSGNEIDNLMAVSIESSDDEA 365
            :  |..|      :|....:.::||..:        |:|.|.:..:...:..:........|.|.
Human   308 L--GLHNYYDVVKNPMDLGTIKEKMDNQ--------EYKDAYKFAADVRLMFMNCYKYNPPDHEV 362

  Fly   366 IDASMRITDADRCATQKLFAKLPTNAMKE--IIHMVQQI----------EGFSSENCGDLSFD-- 416
            :..:..:.|    ..:..|:|:|...::.  :.::...|          |..|..|..|.|.|
Human   363 VTMARMLQD----VFETHFSKIPIEPVESMPLCYIKTDITETTGRENTNEASSEGNSSDDSEDER 423

  Fly   417 VKGLATDTMIMMKSAVTKATRAHSKLKLKDMQP-----SEKEGLQRALQSQLVNITRMLNKN-RR 475
            ||.||        ....:....|.:|::....|     .:||..::..:.:.||.:   |:| |:
Human   424 VKRLA--------KLQEQLKAVHQQLQVLSQVPFRKLNKKKEKSKKEKKKEKVNNS---NENPRK 477

  Fly   476 RCGPLINFRNKNNTANNVVRKRATAPLTAK------LKP--------LQANV---MAPQLG--AG 521
            .|..:   |.|..:..|..:||....:..|      .||        |..|:   ...:||  ..
Human   478 MCEQM---RLKEKSKRNQPKKRKQQFIGLKSEDEDNAKPMNYDEKRQLSLNINKLPGDKLGRVVH 539

  Fly   522 VVETH--NLSDTSDDDVSAPVKLSAIGGTPMRNL-PINSNPLQMQPIRSPPK--LPHVVELQMSS 581
            ::::.  :||:::.|::.  :....:..:.:|.| ...|..|:.:|::.|.|  :....||....
Human   540 IIQSREPSLSNSNPDEIE--IDFETLKASTLRELEKYVSACLRKRPLKPPAKKIMMSKEELHSQK 602

  Fly   582 SSSSESEMKSKSGRLSRSRSRSMSDTKLRPR---SNSSASSRSNSSSSSGSNAGSSSGSRSRSSS 643
            ....|..:...:.:|: ||.|.....|.:|.   .|.|..|.|:|||||.|.:.|||     |..
Human   603 KQELEKRLLDVNNQLN-SRKRQTKSDKTQPSKAVENVSRLSESSSSSSSSSESESSS-----SDL 661

  Fly   644 SSSSSSNNSSE---------SNDSSDVEVVPNV------PEGQ 671
            |||.||::.||         .|||...|.|..:      |||:
Human   662 SSSDSSDSESEMFPKFTEVKPNDSPSKENVKKMKNECIPPEGR 704

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tbrd-2	NP_611401.2	Bromo_gcn5_like	34..136	CDD:99941	43/101 (43%)
BRDT	NP_001229735.2	Bromo_Brdt_I_like	27..133	CDD:99929	46/105 (44%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	206..232		5/35 (14%)
		Nuclear localization signal. /evidence=ECO:0000269|PubMed:22971749	213..224		4/20 (20%)
		Bromo_Brdt_II_like	276..377	CDD:99930	19/118 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	399..424		6/24 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	448..515		17/72 (24%)
		BET	513..575	CDD:435704	10/63 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	614..702		32/93 (34%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	886..928
		BRD4_CDT	909..951	CDD:465349