DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment tbrd-2 and BRDT

DIOPT Version :9

Sequence 1:NP_611401.2 Gene:tbrd-2 / 37207 FlyBaseID:FBgn0034423 Length:674 Species:Drosophila melanogaster
Sequence 2:NP_001229735.2 Gene:BRDT / 676 HGNCID:1105 Length:951 Species:Homo sapiens


Alignment Length:758 Identity:182/758 - (24%)
Similarity:304/758 - (40%) Gaps:151/758 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly    11 LKLPNR--------VQPEFIPHPGMAGRYTNKLHYFKKHLLDEARKKKYALDFLEPVDTEALMVP 67
            :.||:|        ..||:| :....||.||:|.|.:|.:|.:..|..::..|..|||...|.:|
Human     1 MSLPSRQTAIIVNPPPPEYI-NTKKNGRLTNQLQYLQKVVLKDLWKHSFSWPFQRPVDAVKLQLP 64

  Fly    68 TYYTVIHRPMDIGTIVKRVQNNYYKSVNEAIADFKQIISNCFLFNRSGDVVYRKGQMLEKFFHKK 132
            .|||:|..|||:.||.||::|.||...:|.|.||..:.|||:|:|:.||.:....|.|||.|.:|
Human    65 DYYTIIKNPMDLNTIKKRLENKYYAKASECIEDFNTMFSNCYLYNKPGDDIVLMAQALEKLFMQK 129

  Fly   133 LRGMPSGPEVPCNRD----PKAVGRPRTNAPSSAQ-------TERKCRELLKKLQSITNQTDAMT 186
            |..||...:|...::    .||.|..:..|.|||:       ||:..::  :::.|:..:|....
Human   130 LSQMPQEEQVVGVKERIKKGKAGGTQQNIAVSSAKEKSSPSATEKVFKQ--QEIPSVFPKTSISP 192

  Fly   187 RNFFSNKWDSLQKKVDRQYFKSVNEFCLHVDGCFRKYHE--------PAKILYERVFNQPAAWCT 243
            .|.......:...:...|..|.|.          ||...        .|...:...|.:.:....
Human   193 LNVVQGASVNSSSQTAAQVTKGVK----------RKADTTTPATSAVKASSEFSPTFTEKSVALP 247

  Fly   244 SMNGNSSLESALNAADLNELLAAAKLTVNSLMQCVQMPGSGEPLTAK--SLVETFCDTLNKMINK 306
            .:..|.......::.....::...|:| ..|..|.::  ..|.|..|  |....|.:.::  :|.
Human   248 PIKENMPKNVLPDSQQQYNVVKTVKVT-EQLRHCSEI--LKEMLAKKHFSYAWPFYNPVD--VNA 307

  Fly   307 MEAGQRN------SPNPSSSKRQKMSPEQETDLVQGEFKPAMELLSGNEIDNLMAVSIESSDDEA 365
            :  |..|      :|....:.::||..:        |:|.|.:..:...:..:........|.|.
Human   308 L--GLHNYYDVVKNPMDLGTIKEKMDNQ--------EYKDAYKFAADVRLMFMNCYKYNPPDHEV 362

  Fly   366 IDASMRITDADRCATQKLFAKLPTNAMKE--IIHMVQQI----------EGFSSENCGDLSFD-- 416
            :..:..:.|    ..:..|:|:|...::.  :.::...|          |..|..|..|.|.|  
Human   363 VTMARMLQD----VFETHFSKIPIEPVESMPLCYIKTDITETTGRENTNEASSEGNSSDDSEDER 423

  Fly   417 VKGLATDTMIMMKSAVTKATRAHSKLKLKDMQP-----SEKEGLQRALQSQLVNITRMLNKN-RR 475
            ||.||        ....:....|.:|::....|     .:||..::..:.:.||.:   |:| |:
Human   424 VKRLA--------KLQEQLKAVHQQLQVLSQVPFRKLNKKKEKSKKEKKKEKVNNS---NENPRK 477

  Fly   476 RCGPLINFRNKNNTANNVVRKRATAPLTAK------LKP--------LQANV---MAPQLG--AG 521
            .|..:   |.|..:..|..:||....:..|      .||        |..|:   ...:||  ..
Human   478 MCEQM---RLKEKSKRNQPKKRKQQFIGLKSEDEDNAKPMNYDEKRQLSLNINKLPGDKLGRVVH 539

  Fly   522 VVETH--NLSDTSDDDVSAPVKLSAIGGTPMRNL-PINSNPLQMQPIRSPPK--LPHVVELQMSS 581
            ::::.  :||:::.|::.  :....:..:.:|.| ...|..|:.:|::.|.|  :....||....
Human   540 IIQSREPSLSNSNPDEIE--IDFETLKASTLRELEKYVSACLRKRPLKPPAKKIMMSKEELHSQK 602

  Fly   582 SSSSESEMKSKSGRLSRSRSRSMSDTKLRPR---SNSSASSRSNSSSSSGSNAGSSSGSRSRSSS 643
            ....|..:...:.:|: ||.|.....|.:|.   .|.|..|.|:|||||.|.:.|||     |..
Human   603 KQELEKRLLDVNNQLN-SRKRQTKSDKTQPSKAVENVSRLSESSSSSSSSSESESSS-----SDL 661

  Fly   644 SSSSSSNNSSE---------SNDSSDVEVVPNV------PEGQ 671
            |||.||::.||         .|||...|.|..:      |||:
Human   662 SSSDSSDSESEMFPKFTEVKPNDSPSKENVKKMKNECIPPEGR 704

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
tbrd-2NP_611401.2 Bromo_gcn5_like 34..136 CDD:99941 43/101 (43%)
BRDTNP_001229735.2 Bromo_Brdt_I_like 27..133 CDD:99929 46/105 (44%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 206..232 5/35 (14%)
Nuclear localization signal. /evidence=ECO:0000269|PubMed:22971749 213..224 4/20 (20%)
Bromo_Brdt_II_like 276..377 CDD:99930 19/118 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 399..424 6/24 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 448..515 17/72 (24%)
BET 513..575 CDD:293640 10/63 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 614..702 32/93 (34%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 886..928
BRD4_CDT 909..951 CDD:293710
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5076
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
21.860

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