DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tbrd-2 and Brd3

DIOPT Version :9

Sequence 1:	NP_611401.2	Gene:	tbrd-2 / 37207	FlyBaseID:	FBgn0034423	Length:	674	Species:	Drosophila melanogaster
Sequence 2:	NP_001107046.1	Gene:	Brd3 / 67382	MGIID:	1914632	Length:	743	Species:	Mus musculus

Alignment Length:	829	Identity:	167/829 - (20%)
Similarity:	280/829 - (33%)	Gaps:	282/829 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 PNRVQPEFIPHPGMAGRYTNKLHYFKKHLLDEARKKKYALDFLEPVDTEALMVPTYYTVIHRPMD 78
            |....|..:.:|...||.||:|.|.:..::....|.::|..|.:|||...|.:|.|:.:|..|||
Mouse    17 PVNPPPPEVSNPSKPGRKTNQLQYMQNVVVKTLWKHQFAWPFYQPVDAIKLNLPDYHKIIKNPMD 81

  Fly    79 IGTIVKRVQNNYYKSVNEAIADFKQIISNCFLFNRSGDVVYRKGQMLEKFFHKKLRGMPSGPEVP 143
            :|||.||::||||.|.:|.:.||..:.:||:::|:..|.:....|.|||.|.:|:..||......
Mouse    82 MGTIKKRLENNYYWSASECMQDFNTMFTNCYIYNKPTDDIVLMAQALEKIFLQKVAQMPQEEVEL 146

  Fly   144 CNRDPKAVGR-PRTNAPSSAQTERKCRELLKKLQSITNQTDAMTRNFFSNKWDSLQKKVDRQYFK 207
            ....||..|| |...|.::.
Mouse   147 LPPAPKGKGRKPAAGAQNAG--------------------------------------------- 166

  Fly   208 SVNEFCLHVDGCFRKYHEPAKILYERVFNQPAAWCTSMNGNSSLESALNAADLNELLAAAKL-TV 271
                                        :|..|..:|::..:..::.........::||..: |:
Mouse   167 ----------------------------SQQVAAVSSVSPATPFQNIPPTVSQTPVIAATPVPTI 203

  Fly   272 NSLMQCVQMPGSG----------------EPLTAKSLVETFCDTLNKMINKMEAGQRNSPNP-SS 319
            .:.:..|.:|...                .|:..|..|:...||.....:.:.|.:..||.| |.
Mouse   204 TANVTSVPVPPPAAPPPPATPIVPVVPPTPPVVKKKGVKRKADTTTPTTSAITASRSESPPPLSE 268

  Fly   320 SKRQKMSPEQET----------DLVQGE------------------------------------- 337
            .|:.|:...:|:          ||..||
Mouse   269 PKQAKVVARRESGGRPIKPPKKDLEDGEVPQHAGKKGKLSEHLRHCDSILREMLSKKHAAYAWPF 333

  Fly   338 FKP----AMELLSGNEI----DNLMAV-----SIESSDDEAIDASMRITDADRC----------- 378
            :||    |:||...::|    .:|..|     |.|..|.:...|.:|:..:: |
Mouse   334 YKPVDAEALELHDYHDIIKHPMDLSTVKRKMDSREYPDAQGFAADIRLMFSN-CYKYNPPDHEVV 397

  Fly   379 -ATQKL-------FAKLPTNAMK---------EIIHMVQQIEGFSSENCGDLSFDVKGLATDTMI 426
             ..:||       |||:|...|:         .|:....:....|.|:..|..      ::|
Mouse   398 AMARKLQDVFEMRFAKMPDEPMEAPALPAPTAPIVSKGAESSRSSEESSSDSG------SSD--- 453

  Fly   427 MMKSAVTKATRAHSKLKLKDMQPSEKEGLQRALQSQLVNITRM----------------LNKNRR 475
               |...:|||      |.::|  |:.|. .|.|.||:|::.:                :||.::
Mouse   454 ---SEEERATR------LAELQ--EQTGC-GAFQDQLLNVSSVQLKAVHEQLAALSQAPVNKPKK 506

  Fly   476 RCGPLINFRNK----------NNTANNVVRKRATAPLTAK---------LKPLQANVMAPQLGAG 521
            :.......:.|          .:.|.:...|:|.|...||         .|.......:.||..|
Mouse   507 KKEKKEKEKKKKDKDKDKEKEKHKAKSEEEKKAKAAPAAKQAQQKKAPTKKANSTTTASRQLKKG 571

  Fly   522 VVETHNLSDTSDDDVSAPVKLSAIGGTPMRNLPINSNPLQMQPI---------RSP---PKLPHV 574
            ..:.....|:.:::...|:...     ..|.|.::.|.|..:.:         |.|   ...|..
Mouse   572 GKQASASYDSEEEEEGLPMSYD-----EKRQLSLDINRLPGEKLGRVVHIIQSREPSLRDSNPDE 631

  Fly   575 VELQMS--------------------------SSSSSESEMKSKSGRLSRSRSRSMSDTKLRPRS 613
            :|:...                          |:|..:...|||. .|::.:.:.: :.:|:..|
Mouse   632 IEIDFETLKPTTLRELERYVKSCLQKKQRKPLSTSGKKQAAKSKE-ELAQEKKKEL-EKRLQDVS 694

  Fly   614 NSSASSRSNSSSSSGSNAGSSSGSRSRSSSSSSSSSNNSSESNDSSDVE 662
            ....|.:......|||.........|.||||.|:||::|..|:||||.|
Mouse   695 GQLNSKKPTKKEKSGSAPSGGPSRLSSSSSSESASSSSSGSSSDSSDSE 743

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tbrd-2	NP_611401.2	Bromo_gcn5_like	34..136	CDD:99941	38/101 (38%)
Brd3	NP_001107046.1	Bromo_Brdt_I_like	33..139	CDD:99929	41/105 (39%)
		Bromo_Brdt_II_like	310..411	CDD:99930	16/101 (16%)
		BET	589..653	CDD:374956	9/68 (13%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	3	2.860