DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tbrd-2 and Brd4

DIOPT Version :9

Sequence 1:	NP_611401.2	Gene:	tbrd-2 / 37207	FlyBaseID:	FBgn0034423	Length:	674	Species:	Drosophila melanogaster
Sequence 2:	NP_001273559.1	Gene:	Brd4 / 57261	MGIID:	1888520	Length:	1401	Species:	Mus musculus

Alignment Length:	779	Identity:	153/779 - (19%)
Similarity:	273/779 - (35%)	Gaps:	213/779 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 ASCKPLSVKLKLPNRVQPEFIPHPGMAGRYTNKLHYFKKHLLDEARKKKYALDFLEPVDTEALMV 66
            |..:|........|...|| ..:|....|.||:|.|..:.:|....|.::|..|.:|||...|.:
Mouse    31 AQAQPQPANAASTNPPPPE-TSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNL 94

  Fly    67 PTYYTVIHRPMDIGTIVKRVQNNYYKSVNEAIADFKQIISNCFLFNRSGDVVYRKGQMLEKFFHK 131
            |.||.:|..|||:|||.||::||||.:..|.|.||..:.:||:::|:.||.:....:.|||.|.:
Mouse    95 PDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQ 159

  Fly   132 KLRGMPSGPEVPCNRDPKAVGRPR-----------------TNAPSSAQTERKCRELLKKLQSIT 179
            |:..:|:..........|..||.|                 |.|.:|.||:...:.....:|:.|
Mouse   160 KINELPTEETEIMIVQAKGRGRGRKETGRAAKPGVSTVPNTTQASTSPQTQTPQQNPPPPVQATT 224

  Fly   180 NQTDAMTRNFFS------------------------------------------------NKWDS 196
            :...|:|.:..:                                                .....
Mouse   225 HPFPAVTPDLIAQPPVMTMVPPQPLQTPSPVPPQPPPPPAPVPQPVQSHPPIIATTPQPVKTKKG 289

  Fly   197 LQKKVDRQYFKSVNEFCLHVDGCFRKYHEP---------AKILYERVFNQPAAWCTSMNGNSSLE 252
            :::|.|.....:::..           |||         ||:...|..::|..           .
Mouse   290 VKRKADTTTPTTIDPI-----------HEPPSLAPEPKTAKLGPRRESSRPVK-----------P 332

  Fly   253 SALNAADLNELLAAAKLT-VNSLMQCVQMPGSG------------------EPLTAKSL-VETFC 297
            ...:..|..:.....|.: ::..::|.    ||                  :|:..::| :..:|
Mouse   333 PKKDVPDSQQHPGPEKSSKISEQLKCC----SGILKEMFAKKHAAYAWPFYKPVDVEALGLHDYC 393

  Fly   298 DTLNKMINKMEAGQRNSPNPSSSKRQKMSPEQETDLVQGEFKPAMELLSGNEIDNLMAVSIESSD 362
            |.:            ..|...|:.:.|:...:..|  ..||...:.|:..|      .......|
Mouse   394 DII------------KHPMDMSTIKSKLESREYRD--AQEFGADVRLMFSN------CYKYNPPD 438

  Fly   363 DEAIDASMRITDADRCATQKLFAKLPTNAMKEIIHMVQQ---------IEGFSSENCGDLSFDVK 418
            .|.:..:.::.|    ..:..|||:|....:.::.:...         ....||::..|.|.|..
Mouse   439 HEVVAMARKLQD----VFEMRFAKMPDEPEEPVVTVSSPAVPPPTKVVAPPSSSDSSSDSSSDSD 499

  Fly   419 GLATDT-----------MIMMK------SAVTKATRAHSKLKLKDMQPSEKEGLQR--ALQSQLV 464
            ....|:           ...:|      :|:::..:...|.|.||.:..:||..::  .::....
Mouse   500 SSTDDSEEERAQRLAELQEQLKAVHEQLAALSQPQQNKPKKKEKDKKEKKKEKHKKKEEVEENKK 564

  Fly   465 NITRMLNKNRRRCGPLINFRNKNNTANNVVRKRATAPLTAKLKPLQANVMAPQLGAGVVETHNLS 529
            :.|:.|...:.:         |||::|:.|.|:...|...|..|..
Mouse   565 SKTKELPPKKTK---------KNNSSNSNVSKKEPVPTKTKPPPTY------------------- 601

  Fly   530 DTSDDDVSAPVKLSAIGGTPMRNLPINSNPLQMQPIRSPPKLPHVV---ELQMSSSSSSESEMKS 591
            ::.::|...|:...     ..|.|.::.|.|   |.....::.|::   |..:.:|:..|.|:..
Mouse   602 ESEEEDKCKPMSYE-----EKRQLSLDINKL---PGEKLGRVVHIIQSREPSLKNSNPDEIEIDF 658

  Fly   592 KSGRLSRSRSRSMSDTK-LRPRSNSSASSRSNSSSSSGSNAGSSSGSRSRSSSSSSSSSNNSSE 654
            ::.:.|..|......|. ||.:....|......:.||.....|||.|.|.|.||||.|.::.:|
Mouse   659 ETLKPSTLRELERYVTSCLRKKRKPQAEKVDVIAGSSKMKGFSSSESESTSESSSSDSEDSETE 722

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tbrd-2	NP_611401.2	Bromo_gcn5_like	34..136	CDD:99941	40/101 (40%)
Brd4	NP_001273559.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..58		6/27 (22%)
		Bromo_Brdt_I_like	58..164	CDD:99929	43/105 (41%)
		Bromo_Brdt_II_like	355..456	CDD:99930	18/128 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	462..617		27/187 (14%)
		NPS region. /evidence=ECO:0000250	486..505		5/18 (28%)
		BID region. /evidence=ECO:0000250	526..581		12/63 (19%)
		BET	611..675	CDD:407211	13/71 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	676..1126		17/47 (36%)
		PHA03247	<793..1231	CDD:223021
		C-terminal (CTD) region. /evidence=ECO:0000250	1051..1401
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1156..1378
		TPH	<1267..1308	CDD:404709
		BRD4_CDT	1359..1401	CDD:407248
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	3	2.860