DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tbrd-2 and brd4

DIOPT Version :9

Sequence 1:	NP_611401.2	Gene:	tbrd-2 / 37207	FlyBaseID:	FBgn0034423	Length:	674	Species:	Drosophila melanogaster
Sequence 2:	NP_001104751.1	Gene:	brd4 / 570531	ZFINID:	ZDB-GENE-030131-267	Length:	1444	Species:	Danio rerio

Alignment Length:	831	Identity:	166/831 - (19%)
Similarity:	279/831 - (33%)	Gaps:	281/831 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 PNRVQPEFIPHPGMAGRYTNKLHYFKKHLLDEARKKKYALDFLEPVDTEALMVPTYYTVIHRPMD 78
            ||   |....:|....|.||:|.|..|.:|....|.::|..|..|||...|.:|.||.:|..|||
Zfish    30 PN---PPETSNPTRPKRQTNQLQYLLKVVLKSLWKHQFAWPFHAPVDAVKLNLPDYYKIIKNPMD 91

  Fly    79 IGTIVKRVQNNYYKSVNEAIADFKQIISNCFLFNRSGDVVYRKGQMLEKFFHKKLRGMPS----- 138
            :|||.||:::.:|.|..|.|.||..:.:||:::|:.||.:....:.|||.|..|:..||.
Zfish    92 MGTIKKRLESAFYTSAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKVFLTKISEMPQQEVEI 156

  Fly   139 ---------------------GPEV-PCNRDPKAVG------RPRTNAPSSAQTERKCRELLKKL 175
                                 ||.: |....|:..|      .|:|..|.........:.:: ::
Zfish   157 STTAGKGRGRGRRDPDMNMKVGPVLEPLTASPQTRGLSNLTPGPQTRGPPQGPPTLPPQPIV-QI 220

  Fly   176 QSITNQTDAMTRNFFSNKWDSLQKKVDRQYFKSVNEFCLHVDGCFRKYHEPAKILYERVFNQPAA 240
            |::..:..                       .|:....||....     .|...|.....|.||.
Zfish   221 QALPPRVP-----------------------PSLPTIPLHAPQL-----GPPFSLGPTDCNPPAP 257

  Fly   241 WCTSMNGNSSLESALNAADLNELLAAAKLTVNSLMQCVQMPGSGEPLTAKSLVETFCDTLNKMIN 305
            ..|::  ....::||....:.:..|..     .|...:.:|...:  :.|...:|...|.|..:|
Zfish   258 IITAV--PPPTQTALPPVHIQQSAAPP-----ILQTPISIPNKRK--SQKRKADTTTPTANDQLN 313

  Fly   306 KMEAGQ---------RNSPNPSSSKRQKM--------------SPEQETDL------VQGEF--- 338
            :....:         |::..||...:::.              ||:|:..|      |:..|
Zfish   314 ESSPAESKSGKTLPRRDNTRPSKLPKKEAPDSQHHWTAAPGTPSPKQQEQLRYCSGIVKDMFAKK 378

  Fly   339 ---------KPA-MELLSGNEIDNLMAVSIESS-------------------------------- 361
                     ||. ::.|..::..:::...::.|
Zfish   379 HAAYAWPFYKPVDVDTLGLHDYHDIIKHPMDLSTIKDKLETRQYREAQEFAADVRLMFSNCYKYN 443

  Fly   362 --DDEAIDASMRITDADRCATQKLFAKLPTN-------AMKEIIHMVQQIEGFSSENCGDLSFDV 417
              |.|.:..:.::.|    ..:..|||:|..       |...::|..                .|
Zfish   444 PPDHEVVAMARKLQD----VFEMRFAKMPDEPEEMLAPAPAPVLHPA----------------PV 488

  Fly   418 KGLATDTMIMMKSAVTKATRAHSKLKLK-DMQPSEKEGLQR--ALQSQLVNITRML--------- 470
            |     |..:|.:|.:..|.:.|..:.: ....||:|..||  .||.||..:...|
Zfish   489 K-----TQPVMATASSSDTSSDSSSESESSTDDSEEERAQRLAELQEQLKAVHEQLAALSQPQAS 548

  Fly   471 --------------NKNRRRCG------------PLINFRNKNNTANNVVRK------------- 496
                          :|::::.|            |.:..:.|....:.:.:|
Zfish   549 KPKKKEKEKKEKKKDKHKKKAGVMPALEEILEPPPALKPQGKPKNKDPLPKKSKKLSKKEGGKSN 613

  Fly   497 RATAPLTAKLKPLQANVMAPQLGAGVVETHNLSDTSDDDVSAPVKLSAIGGTPMRNLPINS--NP 559
            |:.||..|....||.   .|.|           ||.:|       |...||..|..:....  .|
Zfish   614 RSMAPPGAAPPTLQP---VPGL-----------DTEED-------LGLTGGAAMAGMAAGEKCKP 657

  Fly   560 LQMQPIRSPP----KLP--------HVV---ELQMSSSSSSESEMKSKSGRLS--RSRSRSMSDT 607
            :..:..|...    |||        |::   |..:.:|:..|.|:..::.:.|  |...|.:|..
Zfish   658 MSYEEKRQLSLDINKLPGDKLGRVVHIIQSREPSLKNSNPDEIEIDFETLKPSTLRELERYVSSC 722

  Fly   608 KLRPRSNSSASSRSNSSSSSGSNAGSSSGSRSRSSSSSSSSSNNSSESNDS 658
             ||.:...:...:|..:.|:....|:       ||.|.|||.::||||.||
Zfish   723 -LRKKKKPAVPEKSMEAISAVKTKGT-------SSDSGSSSESSSSESEDS 765

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tbrd-2	NP_611401.2	Bromo_gcn5_like	34..136	CDD:99941	39/101 (39%)
brd4	NP_001104751.1	bromodomain 1; BD1	40..152		44/111 (40%)
		Bromo_Brdt_I_like	43..149	CDD:99929	42/105 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	154..217		8/62 (13%)
		bromodomain 2; BD2	356..473		17/120 (14%)
		Bromo_Brdt_II_like	363..464	CDD:99930	10/104 (10%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	492..523		7/30 (23%)
		NPS region. /evidence=ECO:0000250	498..517		2/18 (11%)
		BID region. /evidence=ECO:0000250	538..610		6/71 (8%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	540..645		19/125 (15%)
		ET domain	654..729		16/75 (21%)
		BET	657..721	CDD:293640	13/63 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1020..1422
		C-terminal (CTD) region. /evidence=ECO:0000250	1126..1444
		BRD4_CDT	<1419..1444	CDD:293710
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	149	1.000	Inparanoid score	I4352
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	3	2.910