DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tbrd-2 and Brd4

DIOPT Version :9

Sequence 1:	NP_611401.2	Gene:	tbrd-2 / 37207	FlyBaseID:	FBgn0034423	Length:	674	Species:	Drosophila melanogaster
Sequence 2:	NP_001094373.1	Gene:	Brd4 / 362844	RGDID:	1307282	Length:	1403	Species:	Rattus norvegicus

Alignment Length:	778	Identity:	154/778 - (19%)
Similarity:	274/778 - (35%)	Gaps:	212/778 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 ASCKPLSVKLKLPNRVQPEFIPHPGMAGRYTNKLHYFKKHLLDEARKKKYALDFLEPVDTEALMV 66
            |..:|.|......|...|| ..:|....|.||:|.|..:.:|....|.::|..|.:|||...|.:
  Rat    31 AQAQPQSANAASTNPPPPE-TSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNL 94

  Fly    67 PTYYTVIHRPMDIGTIVKRVQNNYYKSVNEAIADFKQIISNCFLFNRSGDVVYRKGQMLEKFFHK 131
            |.||.:|..|||:|||.||::||||.:..|.|.||..:.:||:::|:.||.:....:.|||.|.:
  Rat    95 PDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQ 159

  Fly   132 KLRGMPSGPEVPCNRDPKAVGRPR----------------TNAPSSAQTERKCRELLKKLQSITN 180
            |:..:|:..........|..||.|                |.|.:|.||:...:.....:|:.|:
  Rat   160 KINELPTEETEIMIVQAKGRGRGRKETGTAKPGVSTVPNTTQASTSPQTQMPQQNPPPPVQATTH 224

  Fly   181 QTDAMTRNFFS------------------------------------------------NKWDSL 197
            ...|:|.:..:                                                .....:
  Rat   225 PFPAVTPDLIAQPPVMTMVPPQPLQTPSPVPPQPPPPPAPVPQPVQSHPPIIATTPQPVKTKKGV 289

  Fly   198 QKKVDRQYFKSVNEFCLHVDGCFRKYHEP---------AKILYERVFNQPAAWCTSMNGNSSLES 253
            ::|.|.....:::..           |||         ||:...|..::|..           ..
  Rat   290 KRKADTTTPTTIDPI-----------HEPPSLAPEPKTAKLGPRRESSRPVK-----------PP 332

  Fly   254 ALNAADLNELLAAAKLT-VNSLMQCVQMPGSG------------------EPLTAKSL-VETFCD 298
            ..:..|..:.....|.: ::..::|.    ||                  :|:..::| :..:||
  Rat   333 KKDVPDSQQHPGPEKSSKISEQLKCC----SGILKEMFAKKHAAYAWPFYKPVDVEALGLHDYCD 393

  Fly   299 TLNKMINKMEAGQRNSPNPSSSKRQKMSPEQETDLVQGEFKPAMELLSGNEIDNLMAVSIESSDD 363
            .:            ..|...|:.:.|:...:..|  ..||...:.|:..|      .......|.
  Rat   394 II------------KHPMDMSTIKSKLESREYRD--AQEFGADVRLMFSN------CYKYNPPDH 438

  Fly   364 EAIDASMRITDADRCATQKLFAKLPTNAMKEIIHMVQQ---------IEGFSSENCGDLSFDVKG 419
            |.:..:.::.|    ..:..|||:|....:.::.:...         ....||::..|.|.|...
  Rat   439 EVVAMARKLQD----VFEMRFAKMPDEPEEPVVTVSSPAVPPPTKVVAPPSSSDSSSDSSSDSDS 499

  Fly   420 LATDT-----------MIMMK------SAVTKATRAHSKLKLKDMQPSEKEGLQRALQSQLVNIT 467
            ...|:           ...:|      :|:::..:...|.|.||.:..:||..::..:
  Rat   500 STDDSEEERAQRLAELQEQLKAVHEQLAALSQPQQNKPKKKEKDKKEKKKEKHKKKEE------- 557

  Fly   468 RMLNKNRRRCGPLI--NFRNKNNTANNVVRKRATAPLTAKLKPLQANVMAPQLGAGVVETHNLSD 530
              :.:|::.....:  ....|||::|:.|.|:..||...|..|..                   :
  Rat   558 --MEENKKSKAKELPPKKTKKNNSSNSNVSKKEPAPTKTKPPPTY-------------------E 601

  Fly   531 TSDDDVSAPVKLSAIGGTPMRNLPINSNPLQMQPIRSPPKLPHVV---ELQMSSSSSSESEMKSK 592
            :.::|...|:...     ..|.|.::.|.|   |.....::.|::   |..:.:|:..|.|:..:
  Rat   602 SEEEDKCKPMSYE-----EKRQLSLDINKL---PGEKLGRVVHIIQSREPSLKNSNPDEIEIDFE 658

  Fly   593 SGRLSRSRSRSMSDTK-LRPRSNSSASSRSNSSSSSGSNAGSSSGSRSRSSSSSSSSSNNSSE 654
            :.:.|..|......|. ||.:....|......:.||.....|||.|.|.|.||||.|.::.:|
  Rat   659 TLKPSTLRELERYVTSCLRKKRKPQAEKVDVIAGSSKMKGFSSSESESTSESSSSDSEDSETE 721

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tbrd-2	NP_611401.2	Bromo_gcn5_like	34..136	CDD:99941	40/101 (40%)
Brd4	NP_001094373.1	Bromo_Brdt_I_like	58..164	CDD:99929	43/105 (41%)
		Bromo_Brdt_II_like	354..455	CDD:99930	18/128 (14%)
		BET	610..674	CDD:293640	13/71 (18%)
		BRD4_CDT	1361..1403	CDD:293710
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	3	2.860