DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tbrd-2 and Cecr2

DIOPT Version :9

Sequence 1:	NP_611401.2	Gene:	tbrd-2 / 37207	FlyBaseID:	FBgn0034423	Length:	674	Species:	Drosophila melanogaster
Sequence 2:	NP_001355635.1	Gene:	Cecr2 / 330409	MGIID:	1923799	Length:	1453	Species:	Mus musculus

Alignment Length:	645	Identity:	125/645 - (19%)
Similarity:	183/645 - (28%)	Gaps:	255/645 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 LLDEARKKKYALDFLEPVDTEALMVPTYYTVIHRPMDIGTIVKRVQNNYYKSVNEAIADFKQIIS 106
            :||..:..|.:..||||||..  ..|.||.:|..||||.::.|::....|.:..|.:.|.|.:..
Mouse   426 VLDVVKAHKDSWPFLEPVDES--YAPNYYQIIKIPMDISSMEKKLNGGLYCNKEEFVNDMKTMFR 488

  Fly   107 NCFLFNRSGDVVYRKGQMLEKFFHKKLRGMPSGPEVPCNRDPKAVGRPRTNAPSSAQTERKCREL 171
            ||..:|.......:....||:.||:
Mouse   489 NCRKYNGDSSEYTKMSDNLERCFHR---------------------------------------- 513

  Fly   172 LKKLQSITNQTDAMTRNFFSNK-------WDSLQKKVDRQYFKSVNEFCLHV-------DGCFRK 222
                        |||::|....       |....:|.:::..:|......||       :|..||
Mouse   514 ------------AMTKHFPGEDGDTDEEFWIKEDEKREKRRSRSGRSSGSHVWTRSRDTEGSSRK 566

  Fly   223 YHEPAKILYERVFNQPAAWCTSMNGNSSLESALNAADLNELLAAAKLTVNSLMQCVQMPGSGEPL 287
                          ||..    .||..||..|..||...:         :.....:|:|    |.
Mouse   567 --------------QPPV----ENGGKSLPPARRAASSGD---------DQSRSSIQLP----PE 600

  Fly   288 TAKSLVETFCDTLNKMINKMEAGQRNSPNPSSSKRQKMSPEQETDLVQGEFKPAMELLSGNEIDN 352
            ...|..:.|...|:       .|:..|..|..::.:..:|        |.|.
Mouse   601 VGTSHGQGFSRPLH-------CGRVPSHAPPLNQMRPAAP--------GTFG------------- 637

  Fly   353 LMAVSIESSDDEAIDASMRITDADRCATQKLFAKLPTNAMKEIIHMVQQIEGFSSENCGDLSFDV 417
                |::.||...:..|.||.:|.           |...::.....:|...|.|:.. |.|
Mouse   638 ----SLQGSDPTNLHGSSRIPEAP-----------PGEPLQHPPFAIQAPVGISNHR-GSL---- 682

  Fly   418 KGLATDTMIMMKSAVTKATRAHSKLKLKDMQ-PSEKEGLQRALQSQ------------------- 462
              |:...:..|.|.|       ..|:|..|. ||:...:......|
Mouse   683 --LSAPDLSNMGSHV-------PSLQLGQMNCPSQDGNMYPPAPFQAGFIPSRHGGTPARPPDFP 738

  Fly   463 ---------LVNITRMLNKNRRRCGPLINFRNKNNTANNVVRKRATAPLTAKLKPLQANVMAPQL 518
                     :.:..:.||    |..|.: :...:.|.|           ..:|.|.:    .|.|
Mouse   739 ESSEIPPGHIYHSYKYLN----RAHPAV-WNGNHGTTN-----------PGRLGPDE----KPHL 783

  Fly   519 GAGVV-ETHNLSDTSDDDVSAPVKLSAIGGTPMRNLPINSNPLQMQPIRSPPK--------LPHV 574
            |.|.. ..|.|....|             |..||           |||  ||.        |||.
Mouse   784 GPGPSHHPHTLGHMMD-------------GRVMR-----------QPI--PPNQWTKQSSFLPHG 822

  Fly   575 VELQMSSSSSSESEMKSKSGRLSRSRSRSMSDTKLRPRSNSSASSRSNSSSSSGSNAGSS 634
            |    .||...:...||...||...           |....|...|..|.:..|:..|.|
Mouse   823 V----PSSGYMQPPCKSAGHRLQPP-----------PTPAPSPRFRGPSQALRGAQGGES 867

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tbrd-2	NP_611401.2	Bromo_gcn5_like	34..136	CDD:99941	29/93 (31%)
Cecr2	NP_001355635.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	170..237
		Bromo_gcn5_like	418..518	CDD:99941	32/145 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	536..667		36/204 (18%)
		PHA03247	<558..1031	CDD:223021	87/459 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	767..796		10/43 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	827..868		11/52 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	884..1020
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1046..1072
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1131..1308
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1331..1368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1396..1453
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900