DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tbrd-2 and brd3a

DIOPT Version :9

Sequence 1:	NP_611401.2	Gene:	tbrd-2 / 37207	FlyBaseID:	FBgn0034423	Length:	674	Species:	Drosophila melanogaster
Sequence 2:	NP_001116861.1	Gene:	brd3a / 327372	ZFINID:	ZDB-GENE-030131-6141	Length:	683	Species:	Danio rerio

Alignment Length:	786	Identity:	173/786 - (22%)
Similarity:	277/786 - (35%)	Gaps:	275/786 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 NRVQPEFIPHPGMAGRYTNKLHYFKKHLLDEARKKKYALDFLEPVDTEALMVPTYYTVIHRPMDI 79
            |...||.| :|...||.||:|.|.:..::....|.::|..|.:|||...|.:|.|:.:|..|||:
Zfish    16 NPPPPEVI-NPTKPGRKTNQLQYMQNVVVKTLWKHQFAWPFYQPVDAVKLGLPDYHKIIKNPMDM 79

  Fly    80 GTIVKRVQNNYYKSVNEAIADFKQIISNCFLFNRSGDVVYRKGQMLEKFFHKKLRGMPSG----- 139
            |||.||:::.||.|.:|.:.||..:.:||:::|:..|.:....|.|||.|.:|:..||..
Zfish    80 GTIKKRLESVYYYSASECMQDFNTMFTNCYIYNKPTDDIVLMAQALEKIFLQKVALMPQEEVELL 144

  Fly   140 PEVPCNRDPKAVGRPR------TNAPSSAQTERKCRELLKKLQSITNQTDAMTRNFFSNKWDSLQ 198
            |..|..:..|..|..:      |.:|:|         :.....|.::||..::
Zfish   145 PPAPKGKGRKPAGPGQQDGAVSTGSPTS---------VFPGATSPSSQTAVVS------------ 188

  Fly   199 KKVDRQYFKSVNEFCLHVDGCFRKYHEPAKILYERVFNQPAAWCTSMNGNSSLESALNAADLNEL 263
                                       ||.:        ||.       ..|:.:..|..
Zfish   189 ---------------------------PAPV--------PAI-------TPSIPAVQNTT----- 206

  Fly   264 LAAAKLTVNSLMQCVQMPGSGEPLTAKSLVETFCDTLNKMINKMEAGQRNSPNP-SSSKRQKMSP 327
             |||.:.        .||.| :|...|..|:...||.....:.:.|.:..||.| ...|:.|::.
Zfish   207 -AAAVIP--------SMPPS-QPTVKKKGVKRKADTTTPTTSAITASRSQSPTPILEGKQSKVAA 261

  Fly   328 EQET----------DLVQGE-------------------------------------FKP----A 341
            .:|:          |...||                                     :||    |
Zfish   262 RRESTGRPIKPPKKDFEDGELGVHGGKKGRLSEQLKYCDVILKEMLSKKHAAYAWPFYKPVDAEA 326

  Fly   342 MELLSGNEI----DNLMAV-----SIESSDDEAIDASMRITDADRC------------ATQKL-- 383
            :||...::|    .:|..|     |.|..|.:...|.:|:..:: |            ..:||
Zfish   327 LELHDYHDIIKHPMDLSTVKKKMDSREYQDAQTFAADVRLMFSN-CYKYNPPDHEVVAMARKLQD 390

  Fly   384 -----FAKLPTNAMKEIIHMVQQIEG--------------FSSENCGDLSFDVKGLATDTMIMMK 429
                 |||:|...:        ::.|              .|||:.||.|         |.....
Zfish   391 VFEMRFAKMPDEPV--------EVPGAGGVGGAGVVSKSTVSSESSGDSS---------TSDSSD 438

  Fly   430 SAVTKATRAHSKLKLKDMQP--------------SEKEGLQ---------RALQSQLVNITRM-L 470
            |...:|||      |.::|.              ..::|::         :|:..||..:::. :
Zfish   439 SEEERATR------LAELQEQVGAEQCISLEHPIGSRKGIKNGCTKNNQLKAVHEQLAALSQAPV 497

  Fly   471 NKNRRRCGPLINFRNKNNTANNVVRKRATAPLTAKLKPLQ--------ANVMAP--------QLG 519
            :|.:::.......:.|....:|..:....|......||.|        ||...|        ..|
Zfish   498 SKPKKKKEKKEKDKKKKENKHNKSKPEEKAKPGQPPKPAQQKKGPTRKANSTVPGNRQPKKGGRG 562

  Fly   520 AGVVETHNLSDTSDDDVSAPVKLSAIGGTPMRNLPINSNPLQMQPIRSPPKLPHVV---ELQMSS 581
            .|.        .||:::|.|:...     ..|.|.::.|.|   |.....::.|::   |..:..
Zfish   563 PGY--------ESDEEMSLPMTYD-----EKRQLSLDINRL---PGEKLGRVVHIIQSREPSLRD 611

  Fly   582 SSSSESEMKSKSGRLSRSRS-----RSMSDTKLR--PRSNSSASSR-SNSSSSSGSNAGSSSGSR 638
            |:..|.|:..::.:.|..|.     :|....|.|  |:...|..|| |.|||||.|.:.|||||.
Zfish   612 SNPDEIEIDFETLKPSTLRELERYVKSCLQKKQRKPPQKGGSGPSRLSGSSSSSDSGSSSSSGST 676

  Fly   639 SRSSSS 644
            |.||.|
Zfish   677 SDSSDS 682

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tbrd-2	NP_611401.2	Bromo_gcn5_like	34..136	CDD:99941	36/101 (36%)
brd3a	NP_001116861.1	Bromo_Brdt_I_like	30..136	CDD:99929	39/105 (37%)
		Bromo_Brdt_II_like	295..396	CDD:99930	16/101 (16%)
		BET	574..638	CDD:293640	13/71 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	149	1.000	Inparanoid score	I4352
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	3	2.910