DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tbrd-2 and Brd2

DIOPT Version :9

Sequence 1:	NP_611401.2	Gene:	tbrd-2 / 37207	FlyBaseID:	FBgn0034423	Length:	674	Species:	Drosophila melanogaster
Sequence 2:	NP_997660.1	Gene:	Brd2 / 294276	RGDID:	1303324	Length:	798	Species:	Rattus norvegicus

Alignment Length:	893	Identity:	167/893 - (18%)
Similarity:	289/893 - (32%)	Gaps:	380/893 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MASCKPLSVKLKLPNRVQPEFIPHPGMAGRYTNKLHYFKKHLLDEARKKKYALDFLEPVDTEALM 65
            |||...|.:   .|....|..:.:|...||.||:|.|..|.::....|.::|..|.:|||...|.
  Rat    47 MASVPALQL---APANPPPPEVSNPKKPGRVTNQLQYLHKVVMKALWKHQFAWPFRQPVDAVKLG 108

  Fly    66 VPTYYTVIHRPMDIGTIVKRVQNNYYKSVNEAIADFKQIISNCFLFNRSGDVVYRKGQMLEKFFH 130
            :|.|:.:|.:|||:|||.:|::||||.:.:|.:.||..:.:||:::|:..|.:....|.|||.|.
  Rat   109 LPDYHKIIKQPMDMGTIKRRLENNYYWAASECMQDFNTMFTNCYIYNKPTDDIVLMAQTLEKIFL 173

  Fly   131 KKLRGMPS-----------------------------------------------GPEVPC---- 144
            :|:..||.                                               .||:|.
  Rat   174 QKVASMPQEEQELVVTIPKNSHKKGAKLAALQGSITSAHQVPAVSSVSHTALYTPPPEIPTTVLN 238

  Fly   145 ----------------------------------------------------------------- 144

  Rat   239 IPHPSVISSPLLKSLHSAGPPLLAVSAAPPAQPLAKKKGVKRKADTTTPTPTAILAPGSPASPPG 303

  Fly   145 NRDPKAV---------GR----PRTNAPSSAQTE------------RKCRELLKKLQS------- 177
            :.:|||.         ||    ||.:.|.|.|..            :.|..:||:|.|
  Rat   304 SLEPKAARLPPMRRESGRPIKPPRKDLPDSQQQHQSSKKGKLSEQLKHCNGILKELLSKKHAAYA 368

  Fly   178 --ITNQTDAMT------RNFFSNKWD--SLQKKVDRQYFKSVNEFCLHV----DGCFRKYHEPAK 228
              .....||..      .:...:..|  ::::|::.:.::...||...|    ..|: ||:.|
  Rat   369 WPFYKPVDASALGLHDYHDIIKHPMDLSTVKRKMENRDYRDAQEFAADVRLMFSNCY-KYNPP-- 430

  Fly   229 ILYERVFNQPAAWCTSMNGNSSLESALNAADLNELLAAAKLTVNSLMQCVQMPGSGEPLTAKSL- 292
                                          |.:.:..|.||......:..:||  .|||....|
  Rat   431 ------------------------------DHDVVAMARKLQDVFEFRYAKMP--DEPLEPGPLP 463

  Fly   293 VETFCDTLNKMINKMEAGQRNSPNPSSSKR---QKMSPEQETDLVQGEFKPAMELLSGNEIDNLM 354
            |.|          .:..|...|.:.|||:.   :..|.|:|.:..:.|.:.:
  Rat   464 VST----------ALPPGLAKSSSESSSEESSSESSSEEEEEEDEEDEEEES------------- 505

  Fly   355 AVSIESSDDEAIDASMRITDADRCATQKLFAKLPTNAMKEIIHMVQQIEGFSSENCGDLSFDVKG 419
                ||||.|                            :|..|.:           .:|...::.
  Rat   506 ----ESSDSE----------------------------EERAHRL-----------AELQEQLRA 527

  Fly   420 LATDTMIMMKSAVTKATRAHSKLKLKDMQPSEKE----GLQ---------RALQSQLVNITRMLN 471
            :......:.:..::|..|...|.:.|..:.:||.    |:.         |.||.:
  Rat   528 VHEQLAALSQGPISKPKRKREKKEKKKKRKAEKHRGRIGIDEDDKGPRAPRPLQPK--------- 583

  Fly   472 KNRRRCGPLIN--------FRNKNNTANNVVRK-RATAPLTAKLKPLQANVMAPQLGAGVVETHN 527
            |:::..|...|        |.....::|.:.:| :.|||              |.|..|.
  Rat   584 KSKKAGGGGSNATTLSHPGFGTSAGSSNKLPKKAQKTAP--------------PVLPTGY----- 629

  Fly   528 LSDTSDDDVSAPVK----------LSAIGGTPM-RNLPI---------NSNPLQ-------MQP- 564
              |:.:::.|.|:.          ::.:.|..: |.:.|         :|||.:       ::|
  Rat   630 --DSEEEEESRPMSYDEKRQLSLDINKLPGEKLGRVVHIIQAREPSLRDSNPEEIEIDFETLKPS 692

  Fly   565 ------------IRSPPKLPHVV---------ELQMSSSSSSESEMKSKSGRLSRSRSRSMSDTK 608
                        :|..|:.|:.:         ||.:......|..::..||:|:.::
  Rat   693 TLRELERYVLSCLRKKPRKPYTIRKPVGKTKEELALEKKRELEKRLQDVSGQLNSTK-------- 749

  Fly   609 LRPRSNSSASSRSNSSSSSGSNAGSSSGSRSRSSSSSSSSSNNSSESN 656
             :|...:|..:.|::...:.|...:||.|...|||||||||:::|:|:
  Rat   750 -KPPKKASEKTESSAQQVAVSRLSASSSSSDSSSSSSSSSSSDTSDSD 796

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tbrd-2	NP_611401.2	Bromo_gcn5_like	34..136	CDD:99941	37/101 (37%)
Brd2	NP_997660.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	53..72		4/21 (19%)
		Bromo_Brdt_I_like	73..179	CDD:99929	40/105 (38%)
		PHA03247	<215..332	CDD:223021	10/116 (9%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	267..348		10/80 (13%)
		Bromo_Brdt_II_like	348..449	CDD:99930	20/133 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	455..648		48/288 (17%)
		Nuclear localization signal. /evidence=ECO:0000255	553..557		1/3 (33%)
		BET	639..701	CDD:407211	8/61 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	735..798		22/71 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000