DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tbrd-2 and spt7

DIOPT Version :9

Sequence 1:	NP_611401.2	Gene:	tbrd-2 / 37207	FlyBaseID:	FBgn0034423	Length:	674	Species:	Drosophila melanogaster
Sequence 2:	NP_596356.2	Gene:	spt7 / 2540408	PomBaseID:	SPBC25H2.11c	Length:	992	Species:	Schizosaccharomyces pombe

Alignment Length:	801	Identity:	159/801 - (19%)
Similarity:	255/801 - (31%)	Gaps:	279/801 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 RYTNKLHYFKKHLLDEARK--------KKYALDFLEPVDTEALMVPTYYTVIHRPMDIGTIVKRV 86
            ::.|.....::.|.:.|.|        .:::|.||..|....  .|.|||||..|||:|||::.:
pombe   304 KWANDQRIGQEELYEAAEKVVLELRSYTEHSLAFLTKVSKRD--APDYYTVIKEPMDLGTILRNL 366

  Fly    87 QNNYYKSVNEAIADFKQIISNCFLFNRSGD------VVYRKGQMLE-------------KFFHKK 132
            :|.:|.|..|.:.|...|.|||||:|...|      ..:.|.:.||             |.:...
pombe   367 KNLHYNSKKEFVHDLMLIWSNCFLYNSHPDHPLRVHAQFMKDKSLELINLIPDIVIQSRKDYDDS 431

  Fly   133 L--------------------------RGMPSGPEVPCNRDPKAVGRPRTNAPSSAQTERKCREL 171
            |                          ||..:...|..:.|        .|:|....|....:|:
pombe   432 LIEAELESDEESTAETSKHVTSKKTSSRGGQTQQAVEVHTD--------ANSPEENNTPVTKKEV 488

  Fly   172 -LKKLQSITNQTDAMTRNFFSNKWDSLQKK----VDRQYFKSVNEFCLHVDGCFRKYHEPAKILY 231
             ..|..:::..|..:.........::|:|:    |..:|:|...:       ..|:.|    ||.
pombe   489 ETSKPPAVSGSTPPVNEAAVIESSNTLEKEPLSDVATEYWKIKTK-------DIRESH----ILN 542

  Fly   232 ER--------------VFNQPAAWCTSMNGNSSLESALNAADLNELLAAAKLTVNSLMQCVQMP- 281
            .|              :..:|    |:|:.....|.|..:.|   .|...|.....:|:....|
pombe   543 NRRILKSLQFIETELPMIRKP----TAMSAFIDREVAYGSID---CLPMDKGDFEPIMKLDTTPL 600

  Fly   282 -----GSGEPLTAKSLVET-------FCD-------------------------TLNKMINKME- 308
                 |||.|:||.|::||       |.|                         .:.|:.||::
pombe   601 LEYDVGSGVPMTAGSVLETESEEDLYFRDYSLFEINRNTPGVPSLMYKNIAKMQEIRKLCNKIQT 665

  Fly   309 AGQRNSPNPSSSKRQKMS-------------PEQETDLVQGEFKPAMELLSGNEIDNLMAV---- 356
            ..|...|.|...:..|..             |:...::  ..|||    |:.:.:..|..:
pombe   666 VRQLQLPQPFYYEHHKSHVPFANNEPILLDIPQNYDNM--SSFKP----LAHDVLKKLCTIILFH 724

  Fly   357 -SIESSDDEAIDASMRITDADRCATQKLFAKLPTNAMKEIIH----MVQQIEGFSSENCGDLSF- 415
             ..||....|:||...|. ||      ..||:.....:.:|:    ..|:|.|   :..|:|..
pombe   725 AGFESFQMGALDALTEIA-AD------YMAKMGAVMDQYLIYGKDKSQQEIVG---QTLGELGVD 779

  Fly   416 DVKGLATDTMIMMKSAVTKATRAHSKLKLKDMQPSEKEGLQRALQSQLVNITRMLNKNRRRCGPL 480
            ||..|.:.....::....|....|.:                 ||...|.:.|          |.
pombe   780 DVNDLISYVYHDVERQSVKLLEIHQR-----------------LQRHFVELLR----------PA 817

  Fly   481 INFRNKNNTANNVVRKRATAPLTAKLKPLQANVMAPQLGAGVVETHNLSDTSDDDVSAPVKLSAI 545
            ::.||......|                        |.|...| |.|.|..:.||...   |..:
pombe   818 LSERNDEEAIFN------------------------QNGESFV-TGNFSYETGDDFFG---LREL 854

  Fly   546 G-----GTPMRNLPIN-------SNPLQMQP---------IRSPPKLPHVVELQMSSSSSSESEM 589
            |     |....::|::       || :..||         ...|||.|.:      ::.|..:|:
pombe   855 GLDRELGLDSLSVPLHLLQSRLRSN-MSWQPEATIKGDQEYAPPPKYPPI------TAESISNEI 912

  Fly   590 KSKSGRLSRS-----RSRSMSDTKLRPRSNSSASSRSNSSSSSGSNAGSSSGSRSRSSSS----- 644
            ....|.|.::     ....:.|..:||||.........:        |..:..|.|.:||
pombe   913 GLIQGFLKKNLEEFGLDELLEDEDIRPRSKPPRPRLPPN--------GKITTGRKRIASSVFLNQ 969

  Fly   645 SSSSSNNSSESNDSSDVEVVP 665
            |........|:...::|..:|
pombe   970 SLRKKRCLKENEQGTEVTTLP 990

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tbrd-2	NP_611401.2	Bromo_gcn5_like	34..136	CDD:99941	38/154 (25%)
spt7	NP_596356.2	COG5076	161..554	CDD:227408	58/270 (21%)
		Bromo_SPT7_like	309..420	CDD:99942	35/112 (31%)
		Bromo_TP	707..783	CDD:284856	22/89 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	2	1.860