DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tbrd-2 and BRD4

DIOPT Version :9

Sequence 1:	NP_611401.2	Gene:	tbrd-2 / 37207	FlyBaseID:	FBgn0034423	Length:	674	Species:	Drosophila melanogaster
Sequence 2:	NP_001366220.1	Gene:	BRD4 / 23476	HGNCID:	13575	Length:	1362	Species:	Homo sapiens

Alignment Length:	788	Identity:	156/788 - (19%)
Similarity:	272/788 - (34%)	Gaps:	219/788 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 ASCKPLSVKLKLPNRVQPEFIPHPGMAGRYTNKLHYFKKHLLDEARKKKYALDFLEPVDTEALMV 66
            |..:|........|...|| ..:|....|.||:|.|..:.:|....|.::|..|.:|||...|.:
Human    31 AQAQPQPANAASTNPPPPE-TSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNL 94

  Fly    67 PTYYTVIHRPMDIGTIVKRVQNNYYKSVNEAIADFKQIISNCFLFNRSGDVVYRKGQMLEKFFHK 131
            |.||.:|..|||:|||.||::||||.:..|.|.||..:.:||:::|:.||.:....:.|||.|.:
Human    95 PDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQ 159

  Fly   132 KLRGMPSG-----------------------------PEVPCNRDPKAVGRPRTNAPSSAQTERK 167
            |:..:|:.                             |.......|.....|:.|.|....|...
Human   160 KINELPTEETEIMIVQAKGRGRGRKETGTAKPGVSTVPNTTQASTPPQTQTPQPNPPPVQATPHP 224

  Fly   168 CRELLKKLQSITNQTDAMT---------------------------------------RNFFSNK 193
            ...:...|   ..||..||                                       :...:.|
Human   225 FPAVTPDL---IVQTPVMTVVPPQPLQTPPPVPPQPQPPPAPAPQPVQSHPPIIAATPQPVKTKK 286

  Fly   194 WDSLQKKVDRQYFKSVNEFCLHVDGCFRKYHEP---------AKILYERVFNQPAAWCTSMNGNS 249
              .:::|.|.....:::..           |||         .|:...|..::|..
Human   287 --GVKRKADTTTPTTIDPI-----------HEPPSLPPEPKTTKLGQRRESSRPVK--------- 329

  Fly   250 SLESALNAADLNELLAAAKLT-VNSLMQCVQMPGSG------------------EPLTAKSL-VE 294
              ....:..|..:..|..|.: |:..::|.    ||                  :|:..::| :.
Human   330 --PPKKDVPDSQQHPAPEKSSKVSEQLKCC----SGILKEMFAKKHAAYAWPFYKPVDVEALGLH 388

  Fly   295 TFCDTLNKMINKMEAGQRNSPNPSSSKRQKMSPEQETDLVQGEFKPAMELLSGNEIDNLMAVSIE 359
            .:||.:            ..|...|:.:.|:...:..|  ..||...:.|:..|      .....
Human   389 DYCDII------------KHPMDMSTIKSKLEAREYRD--AQEFGADVRLMFSN------CYKYN 433

  Fly   360 SSDDEAIDASMRITDADRCATQKLFAKLPTNAMKEIIHMVQQ---------IEGFSSENCGDLSF 415
            ..|.|.:..:.::.|    ..:..|||:|....:.::.:...         ....||::..|.|.
Human   434 PPDHEVVAMARKLQD----VFEMRFAKMPDEPEEPVVAVSSPAVPPPTKVVAPPSSSDSSSDSSS 494

  Fly   416 DVKGLATDT-----------MIMMK------SAVTKATRAHSKLKLKDMQPSEKEGLQRALQSQL 463
            |......|:           ...:|      :|:::..:...|.|.||.:..:||..:|..:.:
Human   495 DSDSSTDDSEEERAQRLAELQEQLKAVHEQLAALSQPQQNKPKKKEKDKKEKKKEKHKRKEEVE- 558

  Fly   464 VNITRMLNKNRRRCGPLINFRNKNNTANNVVRKRATAPLTAKLKPLQANVMAPQLGAGVVETHNL 528
                  .||..:...|......|||::|:.|.|:..||:.:|..|..
Human   559 ------ENKKSKAKEPPPKKTKKNNSSNSNVSKKEPAPMKSKPPPTY------------------ 599

  Fly   529 SDTSDDDVSAPVKLSAIGGTPMRNLPINSNPLQMQPIRSPPKLPHVVE-LQMSSSSSSESEMKSK 592
             ::.::|...|:...     ..|.|.::.|.|   |.....::.|::: .:.|..:|:..|::..
Human   600 -ESEEEDKCKPMSYE-----EKRQLSLDINKL---PGEKLGRVVHIIQSREPSLKNSNPDEIEID 655

  Fly   593 SGRLSRSRSRSMSDTKLRPRSNSSASSRSNSSSSSGSNAGSSSGSRSRSSSSSSSSSNNSSESND 657
            ...|..|..|.:.    |..::.....|...:......||||. .:..|||.|.|||.:||..::
Human   656 FETLKPSTLRELE----RYVTSCLRKKRKPQAEKVDVIAGSSK-MKGFSSSESESSSESSSSDSE 715

  Fly   658 SSDVEVVP 665
            .|:.|:.|
Human   716 DSETEMAP 723

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tbrd-2	NP_611401.2	Bromo_gcn5_like	34..136	CDD:99941	40/101 (40%)
BRD4	NP_001366220.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..58		6/27 (22%)
		Bromo_Brdt_I_like	58..164	CDD:99929	43/105 (41%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	174..229		6/54 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	242..352		13/133 (10%)
		Bromo_Brdt_II_like	353..454	CDD:99930	18/128 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	463..615		30/182 (16%)
		NPS region	484..503		5/18 (28%)
		BID region	524..579		14/61 (23%)
		BET	609..673	CDD:407211	14/75 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	674..1100		17/51 (33%)
		PRK03427	<809..>922	CDD:235124
		C-terminal (CTD) region	1047..1362
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1116..1339
		BRD4_CDT	1319..1362	CDD:407248
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	2	1.860