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Protein Alignment tbrd-2 and CREBBP

DIOPT Version :9

Sequence 1:	NP_611401.2	Gene:	tbrd-2 / 37207	FlyBaseID:	FBgn0034423	Length:	674	Species:	Drosophila melanogaster
Sequence 2:	NP_004371.2	Gene:	CREBBP / 1387	HGNCID:	2348	Length:	2442	Species:	Homo sapiens

Alignment Length:	739	Identity:	136/739 - (18%)
Similarity:	234/739 - (31%)	Gaps:	247/739 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 KPLSVKLKLPN-RV---QPEFIPHPGMAGRYTN----KLHYFKKHLLDEA---------RKKKYA 52
            :|:.|..|.|. :|   :.|.....|.|.:.|:    :...||...|.:|         |:...:
Human  1044 EPMEVDEKKPEVKVEVKEEEESSSNGTASQSTSPSQPRKKIFKPEELRQALMPTLEALYRQDPES 1108

  Fly    53 LDFLEPVDTEALMVPTYYTVIHRPMDIGTIVKRVQNNYYKSVNEAIADFKQIISNCFLFNRSGDV 117
            |.|.:|||.:.|.:|.|:.::..|||:.||.:::....|:...:.:.|...:.:|.:|:||....
Human  1109 LPFRQPVDPQLLGIPDYFDIVKNPMDLSTIKRKLDTGQYQEPWQYVDDVWLMFNNAWLYNRKTSR 1173

  Fly   118 VYRKGQMLEKFFHKKL------------RGMPSGPEVPCNRDPKAVGRPRTNAPSSAQTE-RKCR 169
            ||:....|.:.|.:::            |.....|:..|....:....||..|..|.|.. ..|.
Human  1174 VYKFCSKLAEVFEQEIDPVMQSLGYCCGRKYEFSPQTLCCYGKQLCTIPRDAAYYSYQNRYHFCE 1238

  Fly   170 ELLKKLQ--SITNQTDAMTRNFFSNKWDSLQKK----VDRQYFKSVNEFCLHVDGCFRKYHEPAK 228
            :...::|  ::|...|........:| |..:||    :|.:.|....|       |.||.|:...
Human  1239 KCFTEIQGENVTLGDDPSQPQTTISK-DQFEKKKNDTLDPEPFVDCKE-------CGRKMHQICV 1295

  Fly   229 ILYERVFNQPAAW----CTSMNGNSSLESALNAADLNELLAAAKLTVNSLMQCVQMPGSGEPLTA 289
            :.|:.::  |:.:    |....|....|:..:|..|                  |....|..|.
Human  1296 LHYDIIW--PSGFVCDNCLKKTGRPRKENKFSAKRL------------------QTTRLGNHLE- 1339

  Fly   290 KSLVETFCDTLNKMINKMEAGQRNSPN---------PSSSKRQKMSPEQETDLV-QGEFKPAM-- 342
                    |.:||.:.:     :|.|.         .||.|..::.|..::..| .||...:.
Human  1340 --------DRVNKFLRR-----QNHPEAGEVFVRVVASSDKTVEVKPGMKSRFVDSGEMSESFPY 1391

  Fly   343 ---ELLSGNEIDNL------MAVSIESSDDEAIDASMRITDADRCATQKLFAKLPTNAMKEIIHM 398
               .|.:..|||.:      |.|....||               |.        |.|..:..|..
Human  1392 RTKALFAFEEIDGVDVCFFGMHVQEYGSD---------------CP--------PPNTRRVYISY 1433

  Fly   399 VQQIEGFSSENC-----------GDLSFDVKGLATDTMIMMKSAVTKAT----RAH---SKL-KL 444
            :..|. |....|           |.|.: ||.|...|..:.....::..    ..|   .|: |.
Human  1434 LDSIH-FFRPRCLRTAVYHEILIGYLEY-VKKLGYVTGHIWACPPSEGDDYIFHCHPPDQKIPKP 1496

  Fly   445 KDMQPSEKEGLQRALQSQLVNITRMLNKNRRRCGPLINFRNKNNTANNVVRKRATAPLTAKLKPL 509
            |.:|...|:.|.:|...::::                ::::        :.|:||.......|.|
Human  1497 KRLQEWYKKMLDKAFAERIIH----------------DYKD--------IFKQATEDRLTSAKEL 1537

  Fly   510 QANVMAPQLGAGVVETHNLSDTSDDDVSAPVKLSAIGGTPMRNLPINSNPLQMQPIRSPPKLPHV 574
                                                                  |.......|:|
Human  1538 ------------------------------------------------------PYFEGDFWPNV 1548

  Fly   575 VELQMSSSSSSESEMKSKSGRLSRSRSRSMSDTKLRPRSNSSASSRSNSSSSSGSNAGSSSGSRS 639
            :|..:......|.|.|.:                    .:::||..:..|.....||...:..::
Human  1549 LEESIKELEQEEEERKKE--------------------ESTAASETTEGSQGDSKNAKKKNNKKT 1593

  Fly   640 RSSSSSSSSSNNSSES--NDSSDV 661
            ..:.||.|.:|....|  |.|:|:
Human  1594 NKNKSSISRANKKKPSMPNVSNDL 1617

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.