DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tbrd-2 and Brdt

DIOPT Version :9

Sequence 1:	NP_611401.2	Gene:	tbrd-2 / 37207	FlyBaseID:	FBgn0034423	Length:	674	Species:	Drosophila melanogaster
Sequence 2:	XP_006534791.1	Gene:	Brdt / 114642	MGIID:	1891374	Length:	961	Species:	Mus musculus

Alignment Length:	842	Identity:	189/842 - (22%)
Similarity:	293/842 - (34%)	Gaps:	340/842 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LKLPNR-------VQPEFIPHPGMAGRYTNKLHYFKKHLLDEARKKKYALDFLEPVDTEALMVPT 68
            :.||:|       ..||:| :...:||.||:|.:.::.:|....|..::..|.:|||...|.:|.
Mouse     1 MSLPSRQTAIVNPPPPEYI-NTKKSGRLTNQLQFLQRVVLKALWKHGFSWPFQQPVDAVKLKLPD 64

  Fly    69 YYTVIHRPMDIGTIVKRVQNNYYKSVNEAIADFKQIISNCFLFNRSGDVVYRKGQMLEKFFHKKL 133
            |||:|..|||:.||.||::|.||:..:|.|.||..:.|||:|:|::||.:....|.|||.|.:||
Mouse    65 YYTIIKTPMDLNTIKKRLENKYYEKASECIEDFNTMFSNCYLYNKTGDDIVVMAQALEKLFMQKL 129

  Fly   134 RGM--------------------------------------------PSG-PEV----------- 142
            ..|                                            ||| |::
Mouse   130 SQMPQEEQVVGGKERIKKDIQQKIAVSSAKEQIPSKAAENVFKRQEIPSGLPDISLSPLNMAQEA 194

  Fly   143 -------------------------------------PCNRDPKAVGRP------RTNAPSSAQ- 163
                                                 |..|:.|.|..|      :...|.|.|
Mouse   195 PPICDSQSLVQITKGVKRRADTTTPTTSIAKASSESPPTLRETKPVNMPVKENTVKNVLPDSQQQ 259

  Fly   164 ---------TE--RKCRELLKKLQS---------ITNQTDAMT---RNFF---SNKWD--SLQKK 200
                     ||  :.|.|:||::.:         ..|..||..   .|::   .|..|  :::.|
Mouse   260 HKVLKTVKVTEQLKHCSEILKEMLAKKHLPYAWPFYNPVDADALGLHNYYDVVKNPMDLGTIKGK 324

  Fly   201 VDRQYFKSVNEFCLHVD----GCFRKYHEP-------------------AKILYERVFNQPAAWC 242
            :|.|.:|...||...|.    .|: ||:.|                   |||..|.:.:..|...
Mouse   325 MDNQEYKDAYEFAADVRLMFMNCY-KYNPPDHEVVAMARTLQDVFELHFAKIPDEPIESMHACHL 388

  Fly   243 T--------------SMNGNSSLESA-----LNAADLNELLAAAKLTVNSLMQCV-QMPGSGEPL 287
            |              :.:|::|.|.:     .:.|.|.|.|.|    |:..:|.: |:|
Mouse   389 TTNSAQALSRESSSEASSGDASSEDSEDERVQHLAKLQEQLNA----VHQQLQVLSQVP------ 443

  Fly   288 TAKSLVETFCDTLNKMINKMEAGQR-------NSPNPSSSKRQKMSPEQETDLVQGEFKPAMELL 345
                        |.|:..|.|..:|       |:.:.:..|:.|...::|...: .:.|....||
Mouse   444 ------------LRKLKKKNEKSKRAPKRKKVNNRDENPRKKPKQMKQKEKAKI-NQPKKKKPLL 495

  Fly   346 SGNEIDNLMAVSIESSDDEAIDASMRITDADRCATQKLFAKLPTNAMKEIIHMVQQIE-GFSSEN 409
            ...|.||...::.:.....::|.:                |||.:.:..|:|::|..| ...:.|
Mouse   496 KSEEEDNAKPMNYDEKRQLSLDIN----------------KLPGDKLGRIVHIIQSREPSLRNSN 544

  Fly   410 CGDLSFDVKGLATDTMIMMKSAVTKATRAHS-KLKLKDMQPSEKEGLQRALQSQLVNITRMLNKN 473
            ..::..|.:.|...|:..::..|....|..| |.:.|.:..|::|     |.|:     :.|...
Mouse   545 PDEIEIDFETLKASTLRELEKYVLACLRKRSLKPQAKKVVRSKEE-----LHSE-----KKLELE 599

  Fly   474 RRRCGPLINFRNKNNTANNVVRKRATAPLTAKLKPLQANVMAPQLGAGVVETHNLSDTSDDDVSA 538
            ||    |::..|:.|     .|||.|.      :|.:.....|
Mouse   600 RR----LLDVNNQLN-----CRKRQTK------RPAKVEKPPP---------------------- 627

  Fly   539 PVKLSAIGGTPMRNLPINSNPLQMQPIRSPPKLPHVVELQMSSSSSSESEMKSKSGRLSRSRSRS 603
                                     |...||..|...||
Mouse   628 -------------------------PPPPPPPPPPPPEL-------------------------- 641

  Fly   604 MSDTKLRPRSNSSASSRSNSSSSSGSNAG---SSSGSRSRSSSSSSSSSNNSSESNDSSDVE 662
                       :|.|..::|||||||.:|   |||||.|.||||.|:||::.|.|:||||.|
Mouse   642 -----------ASGSRLTDSSSSSGSGSGSSSSSSGSSSSSSSSGSASSSSDSSSSDSSDSE 692

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tbrd-2	NP_611401.2	Bromo_gcn5_like	34..136	CDD:99941	41/101 (41%)
Brdt	XP_006534791.1	Bromo_Brdt_I_like	26..132	CDD:99929	44/105 (42%)
		Bromo_Brdt_II_like	271..372	CDD:99930	21/101 (21%)
		BET	505..567	CDD:374956	12/77 (16%)
		BRD4_CDT	919..961	CDD:374989
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	2	1.860