DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment wbl and Erp29

DIOPT Version :9

Sequence 1:	NP_001286609.1	Gene:	wbl / 37206	FlyBaseID:	FBgn0004003	Length:	257	Species:	Drosophila melanogaster
Sequence 2:	NP_446413.1	Gene:	Erp29 / 117030	RGDID:	619781	Length:	260	Species:	Rattus norvegicus

Alignment Length:	266	Identity:	82/266 - (30%)
Similarity:	140/266 - (52%)	Gaps:	28/266 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MMHILVTLLLVA-------IHSIPTTWAVTCTGCVDLDELSFEKTVERFPYSVVKFDIAYPYGEK 58
            ::.:|:.|||::       :|:         .|.:.||.::|.|.:.:..:.:||||..||||||
  Rat    14 LLSVLLGLLLLSAPHGASGLHT---------KGALPLDTVTFYKVIPKSKFVLVKFDTQYPYGEK 69

  Fly    59 HEAFTAFSKSAHKATKDLLIATVGVKDYGELENKALGDRYKVDDKNFPSIFLFKGNADEYVQLPS 123
            .:.|...:::: .::.|||:|.||:.|||:..|..|.::||:|.:::|..:||: :.|....:|.
  Rat    70 QDEFKRLAENS-ASSDDLLVAEVGISDYGDKLNMELSEKYKLDKESYPVFYLFR-DGDFENPVPY 132

  Fly   124 HVDVTLDNLKAFVSANTPLYIGRDGCIKEFNEVLKNYANIPDAEQLKLIEKLQAKQEQLTDPEQQ 188
            ...|.:..::.::... .:|:|..||:..::.:...:......|..:.|  |:..|:.|:..::.
  Rat   133 SGAVKVGAIQRWLKGQ-GVYLGMPGCLPAYDALAGQFIEASSREARQAI--LKQGQDGLSGVKET 194

  Fly   189 QN--ARAYLIYMRKIHEVGYDFLEEETKRLLRLKAGKVTEAKKEELLRKLNILEVFRVHKVTKTA 251
            ..  |..||..|.||.:.|.||...|..|:.:|...|::|.|||||.|.||||..||     |..
  Rat   195 DKKWASQYLKIMGKILDQGEDFPASELARISKLIENKMSEGKKEELQRSLNILTAFR-----KKG 254

  Fly   252 PEKEEL 257
            .|||||
  Rat   255 AEKEEL 260

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wbl	NP_001286609.1	ERp29_N	22..147	CDD:254509	38/124 (31%)
wbl	NP_001286609.1	ERp29	149..242	CDD:285048	30/94 (32%)
Erp29	NP_446413.1	PDI_a_ERp29_N	36..149	CDD:239305	36/115 (31%)
		ERp29	157..250	CDD:400209	30/94 (32%)
		Prevents secretion from ER	257..260		2/2 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166335249
Domainoid	1	1.000	76	1.000	Domainoid score	I8765
eggNOG	1	0.900	-	-		E1_28K2V
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H4963
Inparanoid	1	1.050	121	1.000	Inparanoid score	I4667
OMA	1	1.010	-	-		QHG59606
OrthoDB	1	1.010	-	-		D1535651at2759
OrthoFinder	1	1.000	-	-		FOG0012441
OrthoInspector	1	1.000	-	-		oto97745
orthoMCL	1	0.900	-	-		OOG6_109017
Panther	1	1.100	-	-	LDO	PTHR12211
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.770