DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cora and FRMD5

DIOPT Version :9

Sequence 1:	NP_523791.2	Gene:	cora / 37205	FlyBaseID:	FBgn0010434	Length:	1698	Species:	Drosophila melanogaster
Sequence 2:	NP_116281.2	Gene:	FRMD5 / 84978	HGNCID:	28214	Length:	570	Species:	Homo sapiens

Alignment Length:	400	Identity:	134/400 - (33%)
Similarity:	210/400 - (52%)	Gaps:	22/400 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 SSSSHGKPALARVTLLDGSLLDVSIDRKAIGRDVINSICAGLNLIEKDYFGLTYETPTDPRTWLD 88
            ||.|..:.....|.|||.|....:|.|.|.|:.:.:.:|..|||:||||||:.:..|...|.||:
Human     9 SSRSLEREYSCTVRLLDDSEYTCTIQRDAKGQYLFDLLCHHLNLLEKDYFGIRFVDPDKQRHWLE 73

  Fly    89 LEKPVSKFFRTDTWPLT--FAVKFYPPEPSQLKEDITRYHLCLQVRNDILEGRLPCTFVTHALLG 151
            ..|.|.|..|:.. |.|  |.|||||.:|:.|||:||||.:.||::.|:..|||.|.....|||.
Human    74 FTKSVVKQLRSQP-PFTMCFRVKFYPADPAALKEEITRYLVFLQIKRDLYHGRLLCKTSDAALLA 137

  Fly   152 SYLVQSEMGDYDAEEMPTRAYLKDFKIAPNQTAELEDKVMDLHKTH-KGQSPAEAELHYLENAKK 215
            :|::|:|:||||:.:.| ..|...|:..|..:.:||.|:.::|||. .||:||.:||::|..|:.
Human   138 AYILQAEIGDYDSGKHP-EGYSSKFQFFPKHSEKLERKIAEIHKTELSGQTPATSELNFLRKAQT 201

  Fly   216 LAMYGVDLHPAKDSEGVDIMLGVCASGLLVYRDKLRINRFAWPKILKISYKRHHFYIKIRPGEFE 280
            |..||||.||.||..|....|.....|.:|.:...|::...|.::.|:.::...||:.:  .:.|
Human   202 LETYGVDPHPCKDVSGNAAFLAFTPFGFVVLQGNKRVHFIKWNEVTKLKFEGKTFYLYV--SQKE 264

  Fly   281 QYESTIGFKLANHRAAKKLWKSCVEHHTFFRL---MTPEPVSKSKMFPVFGSTYRYKGRTQAE-- 340
            :.:..:.:......|.|.|||..:|:..|::|   .....||.|.:| ..||.:||.||...|
Human   265 EKKIILTYFAPTPEACKHLWKCGIENQAFYKLEKSSQVRTVSSSNLF-FKGSRFRYSGRVAKEVM 328

  Fly   341 STNTPVDRTPPKFNRTLSGARLTSRSMDALA----LAEKEKVARKSSTLD-HRGDRNADGDAHSR 400
            .::..:.|.||:.:|   ...:.|||..::.    |:...:..|::..:. ..|..:....|||
Human   329 ESSAKIKREPPEIHR---AGMVPSRSCPSITHGPRLSSVPRTRRRAVHISIMEGLESLRDSAHS- 389

  Fly   401 SPIKNKKEKD 410
            :|:::....|
Human   390 TPVRSTSHGD 399

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cora	NP_523791.2	B41	34..224	CDD:214604	83/192 (43%)
		FERM_N	36..98	CDD:286467	26/61 (43%)
		FERM_M	116..224	CDD:278785	47/108 (44%)
		FERM_C_4_1_family	219..312	CDD:270005	25/92 (27%)
		FA	323..363	CDD:285894	12/41 (29%)
		PQQ_2	829..>972	CDD:290097
		4_1_CTD	1612..1698	CDD:283537
FRMD5	NP_116281.2	B41	19..210	CDD:214604	83/192 (43%)
		FERM_C_FRMD3_FRMD5	191..295	CDD:270013	30/105 (29%)
		Interaction with ROCK1. /evidence=ECO:0000269\|PubMed:25448675	308..353		16/48 (33%)
		FA	309..354	CDD:370090	15/48 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	344..367		4/22 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	385..407		4/15 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151651
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3530
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.740