Protein Alignment cora and FRMD5

DIOPT Version :10

• Sequence 1: NP_523791.2
• Gene: cora / 37205
• FlyBaseID: FBgn0010434
• Length: 1698
• Species: Drosophila melanogaster
• Sequence 2: NP_116281.2
• Gene: FRMD5 / 84978
• HGNCID: 28214
• Length: 570
• Species: Homo sapiens
• Alignment Length: 400
• Identity: 134/400 - (33%)
• Similarity: 210/400 - (52%)
• Gaps: 22/400 - (5%)

  Fly    24 SSSSHGKPALARVTLLDGSLLDVSIDRKAIGRDVINSICAGLNLIEKDYFGLTYETPTDPRTWLD 88
            ||.|..:.....|.|||.|....:|.|.|.|:.:.:.:|..|||:||||||:.:..|...|.||:
Human     9 SSRSLEREYSCTVRLLDDSEYTCTIQRDAKGQYLFDLLCHHLNLLEKDYFGIRFVDPDKQRHWLE 73

  Fly    89 LEKPVSKFFRTDTWPLT--FAVKFYPPEPSQLKEDITRYHLCLQVRNDILEGRLPCTFVTHALLG 151
            ..|.|.|..|:.. |.|  |.|||||.:|:.|||:||||.:.||::.|:..|||.|.....|||.
Human    74 FTKSVVKQLRSQP-PFTMCFRVKFYPADPAALKEEITRYLVFLQIKRDLYHGRLLCKTSDAALLA 137

  Fly   152 SYLVQSEMGDYDAEEMPTRAYLKDFKIAPNQTAELEDKVMDLHKTH-KGQSPAEAELHYLENAKK 215
            :|::|:|:||||:.:.| ..|...|:..|..:.:||.|:.::|||. .||:||.:||::|..|:.
Human   138 AYILQAEIGDYDSGKHP-EGYSSKFQFFPKHSEKLERKIAEIHKTELSGQTPATSELNFLRKAQT 201

  Fly   216 LAMYGVDLHPAKDSEGVDIMLGVCASGLLVYRDKLRINRFAWPKILKISYKRHHFYIKIRPGEFE 280
            |..||||.||.||..|....|.....|.:|.:...|::...|.::.|:.::...||:.:  .:.|
Human   202 LETYGVDPHPCKDVSGNAAFLAFTPFGFVVLQGNKRVHFIKWNEVTKLKFEGKTFYLYV--SQKE 264

  Fly   281 QYESTIGFKLANHRAAKKLWKSCVEHHTFFRL---MTPEPVSKSKMFPVFGSTYRYKGRTQAE-- 340
            :.:..:.:......|.|.|||..:|:..|::|   .....||.|.:| ..||.:||.||...|
Human   265 EKKIILTYFAPTPEACKHLWKCGIENQAFYKLEKSSQVRTVSSSNLF-FKGSRFRYSGRVAKEVM 328

  Fly   341 STNTPVDRTPPKFNRTLSGARLTSRSMDALA----LAEKEKVARKSSTLD-HRGDRNADGDAHSR 400
            .::..:.|.||:.:|   ...:.|||..::.    |:...:..|::..:. ..|..:....|||
Human   329 ESSAKIKREPPEIHR---AGMVPSRSCPSITHGPRLSSVPRTRRRAVHISIMEGLESLRDSAHS- 389

  Fly   401 SPIKNKKEKD 410
            :|:::....|
Human   390 TPVRSTSHGD 399

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cora	NP_523791.2	B41	34..224	CDD:214604	83/192 (43%)
		FERM_C_4_1_family	219..312	CDD:270005	25/92 (27%)
		FA	324..364	CDD:462582	12/41 (29%)
		4_1_CTD	1613..1698	CDD:461774
FRMD5	NP_116281.2	B41	19..210	CDD:214604	83/192 (43%)
		FERM_C_FRMD3_FRMD5	191..295	CDD:270013	30/105 (29%)
		Interaction with ROCK1. /evidence=ECO:0000269|PubMed:25448675	308..353		16/48 (33%)
		FA	309..354	CDD:462582	15/48 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	344..367		4/22 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	385..407		4/15 (27%)