DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cora and EPB41L4A

DIOPT Version :9

Sequence 1:	NP_523791.2	Gene:	cora / 37205	FlyBaseID:	FBgn0010434	Length:	1698	Species:	Drosophila melanogaster
Sequence 2:	NP_001334816.1	Gene:	EPB41L4A / 64097	HGNCID:	13278	Length:	708	Species:	Homo sapiens

Alignment Length:	747	Identity:	207/747 - (27%)
Similarity:	327/747 - (43%)	Gaps:	164/747 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 VTLLDGSLLDVSIDRKAI-----GRDVINSICAGLNLIEKDYFGLTYETPTDPRTWLDLEKPVSK 95
            |.|||.|.|.::..::.|     |..|::.:...:||:|.|||||.|...:....|||..|.:::
Human    15 VLLLDESKLTLTTQQQGIKKSTKGSVVLDHVFHHVNLVEIDYFGLRYCDRSHQTYWLDPAKTLAE 79

  Fly    96 FFR-TDTWP---LTFAVKFYPPEPSQLKEDITRYHLCLQVRNDILEGRLPCTFVTHALLGSYLVQ 156
            ... .:|.|   |.|.:|||..:|.:|||:||||...|||:.|:|:|||||...|.|.||:|.:|
Human    80 HKELINTGPPYTLYFGIKFYAEDPCKLKEEITRYQFFLQVKQDVLQGRLPCPVNTAAQLGAYAIQ 144

  Fly   157 SEMGDYDAEEMPTRAYLKDFKIAPNQTAELEDKVMDLHKTHKGQSPAEAELHYLENAKKLAMYGV 221
            ||:||||..: .|..|:.:::..|:|..|||:.:..:|||..||.|:||||:||..||.|.||||
Human   145 SELGDYDPYK-HTAGYVSEYRFVPDQKEELEEAIERIHKTLMGQIPSEAELNYLRTAKSLEMYGV 208

  Fly   222 DLHPAKDSEGVDIMLGVCASGLLVYRDKLRINRFAWPKILKISYKRHHFYIKIRPGEFEQYESTI 286
            ||||.......:..||:...|::||::|.::.::.||:|.|:.:|...|.:::...:..  |::.
Human   209 DLHPVYGENKSEYFLGLTPVGVVVYKNKKQVGKYFWPRITKVHFKETQFELRVLGKDCN--ETSF 271

  Fly   287 GFKLANHRAAKKLWKSCVEHHTFFRLMTPEPVSKSKMFPVFGS---TYRYKGRTQAE-STNTPVD 347
            .|:..:..|.|.|||..||||||||:...|..|.|:....|||   .:||.|||..: |.:..:.
Human   272 FFEARSKTACKHLWKCSVEHHTFFRMPENESNSLSRKLSKFGSIRYKHRYSGRTALQMSRDLSIQ 336

  Fly   348 RTPPKFNRTLSGARLTSRSMDALALAEKEKVARKSSTLDH------------------------- 387
            ...|..|.|.|.::...:.:.....||...::|.::.:::
Human   337 LPRPDQNVTRSRSKTYPKRIAQTQPAESNSISRITANMENGENEGTIKIIAPSPVKSFKKAKNEN 401

  Fly   388 ---------------------------------------RGDRNADGDAHSRSPIKNKKEKDADK 413
                                                   |.:.:...|..|..|::.:|..::.:
Human   402 SPDTQRSKSHAPWEENGPQSGLYNSPSDRTKSPKFPYTRRRNPSCGSDNDSVQPVRRRKAHNSGE 466

  Fly   414 EAKLREKKQKEK-------EEKERKEREKRELEEKKKAEKAAKAALAAGAAAGAAVNGNDELNDS 471
            ::.|:::::...       .|.|...||.|    ||:.....:..:...|....||....:  :.
Human   467 DSDLKQRRRSRSRCNTSSGSESENSNREYR----KKRNRIRQENDMVDSAPQWEAVLRRQK--EK 525

  Fly   472 NKSDKSSGRRGVGIFSSGRKSKSGSPSKDGKDKSGKDKDKEVGRLGLVVTSGLGDNQQDQ---NL 533
            |::|.::.|       |..:|:|.||....|::..|...||     ||..|||.:.|..:   ..
Human   526 NQADPNNRR-------SRHRSRSRSPDIQAKEELWKHIQKE-----LVDPSGLSEEQLKEIPYTK 578

  Fly   534 DEAARNAAKNRGSTTPGVTRQYEYAVDNDGNTS-----PTRKSYTPGGFRYDQDPNSRKSGADGQ 593
            .|...:..:.|.|.:|...|||..:..:||..|     .::....|      ..|.:|.|.|.|.
Human   579 IETQGDPIRIRHSHSPRSYRQYRRSQCSDGERSVLSEVNSKTDLVP------PLPVTRSSDAQGS 637

  Fly   594 -----EQLSPTSQQKKIGLAFNYAPGNENALKETAEKLKAGQLSPRTQDKLNRGQLSPKSRAKLL 653
                 .|...||:.:|         |.|           .|.||      ||:. |...|...||
Human   638 GDATVHQGVQTSRPRK---------GRE-----------LGNLS------LNKA-LQKVSHNTLL 675

  Fly   654 QDPLL-------------SPTTRAKLQGSAVD 672
            .:.:|             |||:.|.:.||.::
Human   676 DEVILGLGWSAHEVMWTESPTSLAAVVGSGIN 707

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cora	NP_523791.2	B41	34..224	CDD:214604	86/196 (44%)
		FERM_N	36..98	CDD:286467	22/66 (33%)
		FERM_M	116..224	CDD:278785	56/107 (52%)
		FERM_C_4_1_family	219..312	CDD:270005	33/92 (36%)
		FA	323..363	CDD:285894	13/43 (30%)
		PQQ_2	829..>972	CDD:290097
		4_1_CTD	1612..1698	CDD:283537
EPB41L4A	NP_001334816.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3530
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810