DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cora and epb41l3

DIOPT Version :9

Sequence 1:	NP_523791.2	Gene:	cora / 37205	FlyBaseID:	FBgn0010434	Length:	1698	Species:	Drosophila melanogaster
Sequence 2:	XP_017950527.2	Gene:	epb41l3 / 613048	XenbaseID:	XB-GENE-1006073	Length:	1407	Species:	Xenopus tropicalis

Alignment Length:	1840	Identity:	478/1840 - (25%)
Similarity:	705/1840 - (38%)	Gaps:	640/1840 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPAEIKPSAPAEPETPTKS-----------KPKSSSSSHGKPAL----------ARVTLLDGSLL 44
            :.||..|....:.|..||.           ..||.||...|..|          |:|.|||||..
Frog    58 LKAEKNPDKDWDKEAATKPLEYQQLEDDKVSQKSGSSKLSKSPLKSARRPKNMQAKVMLLDGSEY 122

  Fly    45 DVSIDRKAIGRDVINSICAGLNLIEKDYFGLTYETPTDPRTWLDLEKPVSKFFRTDTWPLTFAVK 109
            ...:::::.|:.:...:|..|||:|||||||.|....:.:.|||..|.:.|..|...|..:|.||
Frog   123 SCEVEKRSKGQILFEKVCEHLNLLEKDYFGLVYRDSENQKNWLDPAKEIKKQTRNGAWHFSFNVK 187

  Fly   110 FYPPEPSQLKEDITRYHLCLQVRNDILEGRLPCTFVTHALLGSYLVQSEMGDYDAEEMPTRAYLK 174
            ||||:||||.||||||:||||:|:||:.|||||:|||.||||||.||||:||||.||..: .|:.
Frog   188 FYPPDPSQLSEDITRYYLCLQLRDDIVCGRLPCSFVTLALLGSYSVQSELGDYDPEEYGS-DYVT 251

  Fly   175 DFKIAPNQTAELEDKVMDLHKTHKGQSPAEAELHYLENAKKLAMYGVDLHPAKDSEGVDIMLGVC 239
            :|:.|||||.||||||::|||:::|.:|||||:|:|||||||:|||||||.|||||||:||||||
Frog   252 EFRFAPNQTKELEDKVVELHKSYRGMTPAEAEMHFLENAKKLSMYGVDLHHAKDSEGVEIMLGVC 316

  Fly   240 ASGLLVYRDKLRINRFAWPKILKISYKRHHFYIKIRPGEFEQYESTIGFKLANHRAAKKLWKSCV 304
            |||||:|||:||||||||||:|||||||::||||||||||||:||||||||.||||||:|||.||
Frog   317 ASGLLIYRDRLRINRFAWPKVLKISYKRNNFYIKIRPGEFEQFESTIGFKLPNHRAAKRLWKVCV 381

  Fly   305 EHHTFFRLMTPEPVSKSKMFPVFGSTYRYKGRTQAES--TNTPVDRTPPKFNRTLSGARLTSRSM 367
            ||||||||:.||  :..|.|...||.:||.|||||::  .:..:||..|.|.|:.|.....|||:
Frog   382 EHHTFFRLLMPE--APPKKFLTLGSKFRYSGRTQAQTRRASALIDRPAPYFERSSSKRYTMSRSL 444

  Fly   368 DALALAEKEKVARKSSTLDHRGDRNADGDAHSRSPIKNK---KEKDADKEAKLREKKQKEKEEKE 429
            |..::.|...:..|              |:.|.:.:...   ..|...:...:.....::|.|:|
Frog   445 DGASVNENHDLYMK--------------DSVSATEVGTGPYITAKGISQTNLITTVTPEKKAEEE 495

  Fly   430 RKEREKRELEEKKKAEKAAKAALAAGAAAGAAVNGNDELNDSNKSDKSSGRRGVGIFSSGRKSKS 494
            |.|.|    |:|||.|
Frog   496 RDEEE----EKKKKVE------------------------------------------------- 507

  Fly   495 GSPSKDGKDKSGKDKDKEVGRLGLVVTSGLGDNQQDQNLDEAARNAAKNRGSTTPGVTRQYEYAV 559
                                    ::|:                 ....|..|.|.       ..
Frog   508 ------------------------IITT-----------------VTTIRHDTKPS-------CF 524

  Fly   560 DNDGNTSPTRKSYTPGGFRYDQDPNSRKSGADGQEQLSPTSQQKKIGLAFNYAPGNENALKETAE 624
            |.|...||:.             |:|           ||::...|:          ....||.|.
Frog   525 DTDSFHSPSH-------------PHS-----------SPSASSTKL----------RRRCKENAR 555

  Fly   625 KLKAGQLSPRT--------QDKLNRGQLSPKSRAKLLQDPLLSPTTRAKLQGSAVDAAAVPLSDS 681
            |....:||...        :|...:|.|.|:      :|.|.....:...:|..:.:.::.|.|
Frog   556 KAVGRELSKDVNEMSHEPERDSDCKGTLYPE------EDELAISYKQQAGRGGTLFSFSLHLPD- 613

  Fly   682 QKRSYSPTKGPQGY--------SSGAPGS---YKPISDPTA--------DFLESQRYNKEPG--- 724
               |:.......||        ::..|.|   |.||..|:.        .||.|..::....
Frog   614 ---SFPSLLDDDGYLSFPNISETNFLPESLQHYLPIRSPSLVPCFLFIFFFLLSASFSVPYALTL 675

  Fly   725 ---------YVGPSKADVAAGLAG--AAGSKKPGSPTKTGKGAPGAAAAAAAGAAGAAAAAAKPK 778
                     |:.|....::|.|..  :..|.......:|...|.|...|..:.......|..:
Frog   676 SFPLAMCLCYLEPKAVSLSAALDNDLSDSSDDETDSEQTDTAADGETTATESDQEEDTYAKTQ-- 738

  Fly   779 KRRVKIMVITSKFDPSTKRIDAENGSIEHSTGILDPATGLIDTKYGVIDPKKGTLEALNTKTGKK 843
                         :...|||..||..::||..:|:             :..:...|.:..:|...
Frog   739 -------------NSLIKRIKGENVYVKHSNLMLE-------------EFDRNQEELMKHQTNIS 777

  Fly   844 EVFQGDVDGKTGNLHLVSGVADPKTG-----RLDDTLGQIVCITPQDNPVVELTVITSRIDPATG 903
            |:.:..::..|          |..||     ||..:..::| :..::.|::|..|      |...
Frog   778 ELKRTFLETST----------DTTTGGEWEKRLSTSPVRLV-MRHEEAPMIEPLV------PEET 825

  Fly   904 KIDTVNGDVERSLGVLNLDTGLLDTKYGEINTRTGELKAIDP--KSGKIVVSKNVKVDP-GTGQI 965
            |.:....:::.||.  .....:|:::.|:|..:..|.:|..|  .|.:|::.|.:...| ||...
Frog   826 KEEREKREIQMSLE--RTSYSMLESQPGDIVKKLREARATSPVATSQQIIMQKTIPTSPEGTEDW 888

  Fly   966 TILGIVDPKTNKIDPNQGRLIEVGQQIDPIVEVTSLAGKFDSKRNIIDPKTAQVETSGGQFDPKA 1030
            .|:..|..|                                    ::|.:|..:.|
Frog   889 VIIDKVPTK------------------------------------VVDGETKTIVT--------- 908

  Fly  1031 GKIDTKYGQIDLVKHTITFNDPKSGKTVTRDIKIEPTTGQIVLKNQVNPKNNKPDKDYARIISLR 1095
                        .|.|...:|..:|     ..|..|..||.:...::..|:.:.|..    :.:.
Frog   909 ------------YKVTTVSSDMPAG-----TFKTSPLGGQSLDALKMELKSKEEDSK----LKMY 952

  Fly  1096 IVQQRVDPATKAPITEVSASKDKDIVVDPKSNQIWVPTGATDPATKEQQYISSSVDPKTGYVITI 1160
            .:.:..|..:...:|..|.:|:.|....|.|.:|
Frog   953 TLGRSYDTVSGKVVTMTSKAKEGDKEKTPSSFEI------------------------------- 986

  Fly  1161 YGYLDPKTNEIKKQTKLDPNTIKIEPTSGKIYTATGEVDQATGEPLYAATQVDPESGEVYTKLAR 1225
                      |:|..|....||||.|.:|         |....||:
Frog   987 ----------IQKLEKDIAETIKIAPGTG---------DYEILEPI------------------- 1013

  Fly  1226 VDPKTGKIVIVRILLISKTDERGRPEEIDPSTCEIDPVSGRVLKFFNKTVYVYNMIDPVTGEIVQ 1290
                              :|::||.....|      ||..|                 ::..:..
Frog  1014 ------------------SDDKGRKVPEGP------PVKRR-----------------MSETLTP 1037

  Fly  1291 VDPNDPRFAGARTTVTHTMTLTGEIDPVTGRIKSEYGDIDPNTGDIDPATAVTDPVTGKLILNYA 1355
            :..:|.:.|                .||...:|.                 |.|..|.|.:
Frog  1038 IKESDSQLA----------------SPVEETLKK-----------------VQDKDTEKNL---- 1065

  Fly  1356 QIDPSHFGKQAQVQTTTETVPITRQQFFDGVKHISKGALRRDSEGSSDDDMTA-QYGADQVNEIL 1419
             |:...|||..|.|.            :|.:|        .|.....|..::. :|..||
Frog  1066 -IESVIFGKAEQFQD------------YDVIK--------ADVPSWKDKKLSEWRYTRDQ----- 1104

  Fly  1420 IGSPAGQAGGKLGKPVSTPT---VVKTTTKQVLTKNIDGVTHNVEEEVRNLGTGEVTYSTQEHKA 1481
                          |.:..|   |.:::..:|:||.               .:||.|
Frog  1105 --------------PFTIATAHYVTESSASKVVTKQ---------------SSGEKT-------- 1132

  Fly  1482 DATPTDLSGAYVTATAVTTRTATTHEDLGKNAKTEQ-LEEKTVATTRTHDPNKQQ--------QR 1537
                  |.|:.:.:...:||..:  |.||:...|.| ..:||..||.....:|.|        ::
Frog  1133 ------LEGSDIYSLLESTRKPS--EFLGEVTSTSQSWAQKTETTTEWDSSSKGQEDAEQKAKEK 1189

  Fly  1538 VVTQEVKTTATVTSGDQYQRRDS-------VSSTSSGDSGTP----------------------- 1572
            ||...|....::. |..:..||:       ::|:..||.|:.
Frog  1190 VVQGMVSLEESLV-GSVHASRDAAELAGTVIASSLKGDEGSTLKKEPEEDLAVDASACYAQEEQH 1253

  Fly  1573 -------IDG-PYDGASVVRT---------DNQKSPLFTTSATTGPHVESTRVV-----LGEDTP 1615
                   :|| |...:.||:|         |.:| |..:|......|.|:..:.     ||..|.
Frog  1254 GSKVHELLDGKPQVESPVVKTEIITFGTIADGEK-PDISTKDVPVVHTETKTITYESSELGSRTD 1317

  Fly  1616 GFSGHGEIISTQTVSSKTRTVETITY--KTERDGIVETRVEQKITIQSDGDPIDHDKALAEAIQE 1678
              :..|.::|.||::|:|....|.|:  ||.:.||.|||:|::|.|..|.| ||||:|||:||:|
Frog  1318 --TDPGMLMSAQTITSETFGTTTTTHITKTVKGGISETRIEKRIVITGDAD-IDHDQALAQAIKE 1379

  Fly  1679 ATAMNPDMTVEKIEIQQQTQ 1698
            |...:|||:|.|:.:.::|:
Frog  1380 AKEQHPDMSVTKVVVHKETE 1399

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cora	NP_523791.2	B41	34..224	CDD:214604	110/189 (58%)
		FERM_N	36..98	CDD:286467	24/61 (39%)
		FERM_M	116..224	CDD:278785	75/107 (70%)
		FERM_C_4_1_family	219..312	CDD:270005	81/92 (88%)
		FA	323..363	CDD:285894	16/41 (39%)
		PQQ_2	829..>972	CDD:290097	30/150 (20%)
		4_1_CTD	1612..1698	CDD:283537	37/87 (43%)
epb41l3	XP_017950527.2	B41	112..301	CDD:214604	110/189 (58%)
		FERM_C_4_1_family	296..389	CDD:270005	81/92 (88%)
		FA	398..441	CDD:400882	16/42 (38%)
		SAB	758..806	CDD:398195	10/70 (14%)
		4_1_CTD	1294..1399	CDD:399118	41/107 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	169	1.000	Domainoid score	I3756
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	551	1.000	Inparanoid score	I1111
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001068
OrthoInspector	1	1.000	-	-		otm48868
Panther	1	1.100	-	-	O	PTHR23280
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4459
SonicParanoid	1	1.000	-	-		X1151
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	9.090